Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210404798> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4210404798 endingPage "264" @default.
- W4210404798 startingPage "257" @default.
- W4210404798 abstract "This study presents the modern concepts of pathogenesis, risk factors, etiology, clinical manifestations, prevention, and treatment of oropharyngeal mucositis, one of the main complications of radiation therapy for head and neck region cancer. The leading role in the mechanisms of disease development belongs to rapidly dividing cells of the basal layer of the oropharyngeal mucous membrane. This damage is due to both direct (excitation and ionization) and indirect (accumulation of active oxygen and nitrogen compounds, activation of transcription factors, hyperfunction of pro-inflammatory cytokines, etc.) action of ionizing radiation on the most important biological molecules and supramolecular structures (polynucleotides, nucleoproteins, phospholipids, etc.). The main risk factors for mucositis include the localization and size of the tumor, the amount of radiation dose to the oral region, and individual body characteristics (young age, pernicious habits, metal structures of dentures, a history of periodontal disease, etc.). The disease severity is described from mild (erythema and moderate pain that does not require analgesia) to severe (ulceration, hemorrhage, necrosis, and other symptoms) to establishment necessary prescription of effective means of pathogenetic and symptomatic therapy. The main means and methods of prevention of radiation-induced mucositis include the following: non-steroidal anti-inflammatory drug benzydamine, means of protection against oxidative stress glutamine, and drugs with a complex stimulating effect on wound healing processes. Drug therapy for mucositis involves the use of benzydamine; the tricyclic antidepressant doxepin; and a gel consisting of polyvinylpyrrolidone (Belclaiz), mucolytic acetylcysteine. When non-narcotic analgesics are ineffective, low doses of opiates (fentanyl, morphine, and methadone) are used in oral, transdermal, or parenteral dosage forms, as well as low-intensity laser therapy. The most important components of the etiopathogenetic therapy of the disease include antiviral drugs (acyclovir and valacyclovir) and fungicides (clotrimazole, fluconazole, and itraconazole). Enteral nutrition difficulty indicates nasogastric or nasojejunal tube usage, and in more serious cases, surgical methods such as gastro- or jejunostomy." @default.
- W4210404798 created "2022-02-08" @default.
- W4210404798 creator A5004752397 @default.
- W4210404798 creator A5025780325 @default.
- W4210404798 creator A5027428319 @default.
- W4210404798 creator A5038373276 @default.
- W4210404798 creator A5039782222 @default.
- W4210404798 creator A5046741347 @default.
- W4210404798 date "2021-12-15" @default.
- W4210404798 modified "2023-09-26" @default.
- W4210404798 title "Radiation-induced oral mucositis — radiation-induced oral mucositis: pathogenesis, risk factors, clinical manifestations, prevention, and treatment" @default.
- W4210404798 cites W1261284821 @default.
- W4210404798 cites W1491651242 @default.
- W4210404798 cites W1520000195 @default.
- W4210404798 cites W171336274 @default.
- W4210404798 cites W1825534538 @default.
- W4210404798 cites W1966996796 @default.
- W4210404798 cites W1967208836 @default.
- W4210404798 cites W1968960139 @default.
- W4210404798 cites W1974435522 @default.
- W4210404798 cites W1976971060 @default.
- W4210404798 cites W1984389010 @default.
- W4210404798 cites W1995406926 @default.
- W4210404798 cites W1999378117 @default.
- W4210404798 cites W2002434904 @default.
- W4210404798 cites W2009816300 @default.
- W4210404798 cites W2010318197 @default.
- W4210404798 cites W2011900402 @default.
- W4210404798 cites W2013602932 @default.
- W4210404798 cites W2018859387 @default.
- W4210404798 cites W2034314920 @default.
- W4210404798 cites W2039183713 @default.
- W4210404798 cites W2043922695 @default.
- W4210404798 cites W2048874935 @default.
- W4210404798 cites W2091406076 @default.
- W4210404798 cites W2101420976 @default.
- W4210404798 cites W2140581475 @default.
- W4210404798 cites W2141657818 @default.
- W4210404798 cites W2143454069 @default.
- W4210404798 cites W2144418492 @default.
- W4210404798 cites W2146561637 @default.
- W4210404798 cites W2147428677 @default.
- W4210404798 cites W2163643208 @default.
- W4210404798 cites W2655326870 @default.
- W4210404798 cites W384745426 @default.
- W4210404798 cites W4239051128 @default.
- W4210404798 doi "https://doi.org/10.17816/brmma65173" @default.
- W4210404798 hasPublicationYear "2021" @default.
- W4210404798 type Work @default.
- W4210404798 citedByCount "1" @default.
- W4210404798 countsByYear W42104047982022 @default.
- W4210404798 crossrefType "journal-article" @default.
- W4210404798 hasAuthorship W4210404798A5004752397 @default.
- W4210404798 hasAuthorship W4210404798A5025780325 @default.
- W4210404798 hasAuthorship W4210404798A5027428319 @default.
- W4210404798 hasAuthorship W4210404798A5038373276 @default.
- W4210404798 hasAuthorship W4210404798A5039782222 @default.
- W4210404798 hasAuthorship W4210404798A5046741347 @default.
- W4210404798 hasConcept C121608353 @default.
- W4210404798 hasConcept C126322002 @default.
- W4210404798 hasConcept C2778496288 @default.
- W4210404798 hasConcept C509974204 @default.
- W4210404798 hasConcept C71924100 @default.
- W4210404798 hasConcept C90924648 @default.
- W4210404798 hasConcept C98274493 @default.
- W4210404798 hasConceptScore W4210404798C121608353 @default.
- W4210404798 hasConceptScore W4210404798C126322002 @default.
- W4210404798 hasConceptScore W4210404798C2778496288 @default.
- W4210404798 hasConceptScore W4210404798C509974204 @default.
- W4210404798 hasConceptScore W4210404798C71924100 @default.
- W4210404798 hasConceptScore W4210404798C90924648 @default.
- W4210404798 hasConceptScore W4210404798C98274493 @default.
- W4210404798 hasIssue "4" @default.
- W4210404798 hasLocation W42104047981 @default.
- W4210404798 hasOpenAccess W4210404798 @default.
- W4210404798 hasPrimaryLocation W42104047981 @default.
- W4210404798 hasRelatedWork W12776443 @default.
- W4210404798 hasRelatedWork W12959130 @default.
- W4210404798 hasRelatedWork W17070268 @default.
- W4210404798 hasRelatedWork W2184758 @default.
- W4210404798 hasRelatedWork W4046534 @default.
- W4210404798 hasRelatedWork W4811995 @default.
- W4210404798 hasRelatedWork W6063984 @default.
- W4210404798 hasRelatedWork W7168267 @default.
- W4210404798 hasRelatedWork W7246245 @default.
- W4210404798 hasRelatedWork W9961594 @default.
- W4210404798 hasVolume "23" @default.
- W4210404798 isParatext "false" @default.
- W4210404798 isRetracted "false" @default.
- W4210404798 workType "article" @default.