FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210405243> ?p ?o ?g. }

• W4210405243 abstract "Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is no FDA-approved treatment for these neurotoxicities. We investigated the capacity of a highly selective A3 adenosine receptor (AR) subtype (A3AR) agonist, MRS5980, to prevent and reverse cisplatin-induced neurotoxicities. MRS5980 prevented cisplatin-induced cognitive impairment (decreased executive function and impaired spatial and working memory), sensorimotor deficits, and neuropathic pain (mechanical allodynia and spontaneous pain) in both sexes. At the structural level, MRS5980 prevented the cisplatin-induced reduction in markers of synaptic integrity. In-situ hybridization detected Adora3 mRNA in neurons, microglia, astrocytes and oligodendrocytes. RNAseq analysis identified 164 genes, including genes related to mitochondrial function, of which expression was changed by cisplatin and normalized by MRS5980. Consistently, MRS5980 prevented cisplatin-induced mitochondrial dysfunction and decreased signs of oxidative stress. Transcriptomic analysis showed that the A3AR agonist upregulates genes related to repair pathways including NOTCH1 signaling and chromatin modification in the cortex of cisplatin-treated mice. Importantly, A3AR agonist administration after completion of cisplatin treatment resolved cognitive impairment, neuropathy and sensorimotor deficits. Our results highlight the efficacy of a selective A3AR agonist to prevent and reverse cisplatin-induced neurotoxicities via preventing brain mitochondrial damage and activating repair pathways. An A3AR agonist is already in cancer, clinical trials and our results demonstrate management of neurotoxic side effects of chemotherapy as an additional therapeutic benefit." @default.
• W4210405243 created "2022-02-08" @default.
• W4210405243 creator A5007674783 @default.
• W4210405243 creator A5009768215 @default.
• W4210405243 creator A5010450034 @default.
• W4210405243 creator A5025647599 @default.
• W4210405243 creator A5027911316 @default.
• W4210405243 creator A5037079426 @default.
• W4210405243 creator A5044879059 @default.
• W4210405243 creator A5046036725 @default.
• W4210405243 creator A5052737204 @default.
• W4210405243 creator A5065208828 @default.
• W4210405243 date "2022-01-29" @default.
• W4210405243 modified "2023-10-17" @default.
• W4210405243 title "Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice" @default.
• W4210405243 cites W1826976540 @default.
• W4210405243 cites W1970069445 @default.
• W4210405243 cites W2013795726 @default.
• W4210405243 cites W2055397053 @default.
• W4210405243 cites W2062046115 @default.
• W4210405243 cites W2069423981 @default.
• W4210405243 cites W2069947062 @default.
• W4210405243 cites W2083577791 @default.
• W4210405243 cites W2087838893 @default.
• W4210405243 cites W2088728113 @default.
• W4210405243 cites W2093924523 @default.
• W4210405243 cites W2095909361 @default.
• W4210405243 cites W2098192159 @default.
• W4210405243 cites W2098865088 @default.
• W4210405243 cites W2102517422 @default.
• W4210405243 cites W2109158925 @default.
• W4210405243 cites W2110905563 @default.
• W4210405243 cites W2114718178 @default.
• W4210405243 cites W2133496177 @default.
• W4210405243 cites W2161018896 @default.
• W4210405243 cites W2171894045 @default.
• W4210405243 cites W2172201406 @default.
• W4210405243 cites W2179438025 @default.
• W4210405243 cites W2290466312 @default.
• W4210405243 cites W2321697502 @default.
• W4210405243 cites W2410597558 @default.
• W4210405243 cites W2460778061 @default.
• W4210405243 cites W2487811171 @default.
• W4210405243 cites W2556049444 @default.
• W4210405243 cites W2593043086 @default.
• W4210405243 cites W2607014149 @default.
• W4210405243 cites W2727679898 @default.
• W4210405243 cites W2744829308 @default.
• W4210405243 cites W2790265924 @default.
• W4210405243 cites W2791843796 @default.
• W4210405243 cites W2892954306 @default.
• W4210405243 cites W2894687190 @default.
• W4210405243 cites W2899430940 @default.
• W4210405243 cites W2912076589 @default.
• W4210405243 cites W2928555551 @default.
• W4210405243 cites W2935334079 @default.
• W4210405243 cites W2963948807 @default.
• W4210405243 cites W2965706021 @default.
• W4210405243 cites W3004443958 @default.
• W4210405243 cites W3027150262 @default.
• W4210405243 cites W3041640853 @default.
• W4210405243 cites W3043316470 @default.
• W4210405243 cites W3099599005 @default.
• W4210405243 cites W3100864068 @default.
• W4210405243 cites W3101732591 @default.
• W4210405243 cites W3111816102 @default.
• W4210405243 cites W3119784023 @default.
• W4210405243 cites W3120043613 @default.
• W4210405243 cites W3130373423 @default.
• W4210405243 cites W3145969289 @default.
• W4210405243 cites W3184102753 @default.
• W4210405243 cites W3197608214 @default.
• W4210405243 cites W4248572010 @default.
• W4210405243 doi "https://doi.org/10.1186/s40478-022-01315-w" @default.
• W4210405243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35093182" @default.
• W4210405243 hasPublicationYear "2022" @default.
• W4210405243 type Work @default.
• W4210405243 citedByCount "15" @default.
• W4210405243 countsByYear W42104052432022 @default.
• W4210405243 countsByYear W42104052432023 @default.
• W4210405243 crossrefType "journal-article" @default.
• W4210405243 hasAuthorship W4210405243A5007674783 @default.
• W4210405243 hasAuthorship W4210405243A5009768215 @default.
• W4210405243 hasAuthorship W4210405243A5010450034 @default.
• W4210405243 hasAuthorship W4210405243A5025647599 @default.
• W4210405243 hasAuthorship W4210405243A5027911316 @default.
• W4210405243 hasAuthorship W4210405243A5037079426 @default.
• W4210405243 hasAuthorship W4210405243A5044879059 @default.
• W4210405243 hasAuthorship W4210405243A5046036725 @default.
• W4210405243 hasAuthorship W4210405243A5052737204 @default.
• W4210405243 hasAuthorship W4210405243A5065208828 @default.
• W4210405243 hasBestOaLocation W42104052431 @default.
• W4210405243 hasConcept C126322002 @default.
• W4210405243 hasConcept C134018914 @default.
• W4210405243 hasConcept C169760540 @default.
• W4210405243 hasConcept C170493617 @default.
• W4210405243 hasConcept C2776694085 @default.
• W4210405243 hasConcept C2776914184 @default.
• W4210405243 hasConcept C2777107010 @default.
• W4210405243 hasConcept C2778239845 @default.

• next