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• W4210406736 abstract "HLA is a critical component of the viral antigen presentation pathway. We investigated the relationship between the severity of SARS-CoV-2 disease and HLA type in 3235 individuals with confirmed SARS-CoV-2 infection. We found only the DPB1 locus to be associated with the binary outcome of whether an individual developed any COVID-19 symptoms. The number of peptides predicted to bind to an HLA allele had no significant relationship with disease severity both when stratifying individuals by ancestry or age and in a pooled analysis. Overall, at the population level, we found HLA type is significantly less predictive of COVID-19 disease severity than certain demographic factors and clinical comorbidities." @default.
• W4210406736 created "2022-02-08" @default.
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• W4210406736 date "2022-02-24" @default.
• W4210406736 modified "2023-09-30" @default.
• W4210406736 title "Minimal observed impact of<scp>HLA</scp>genotype on hospitalization and severity of<scp>SARS‐CoV</scp>‐2 infection" @default.
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• W4210406736 doi "https://doi.org/10.1111/tan.14574" @default.
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