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- W4210432890 abstract "Ruby-red alert It’s citrus season here in the US! Sweet satsumas and crimson blood oranges are on display at grocery stores. However, if you’re taking any prescription drugs, you may want to choose your fruit carefully. Grapefruit is notorious for messing with medication. Grapefruit and other bitter citrus berries contain high levels of furanocoumarins. This class of molecules irreversibly deactivates cytochrome P450 enzymes, which help your body break down drugs. Drugmakers usually expect a certain fraction of the active ingredients in a medication to break down before arriving at their destination in the body, so the amount in each pill is scaled up accordingly. But if the enzymes that are supposed to break the drug down are sidelined, more of it than expected will make it into your system. For some medications, this increase poses the risk of a dangerous overdose. A single grapefruit is enough to decimate the P450s" @default.
- W4210432890 created "2022-02-08" @default.
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- W4210432890 date "2022-01-31" @default.
- W4210432890 modified "2023-10-16" @default.
- W4210432890 title "Interfering grapefruit and low-stress tomatoes" @default.
- W4210432890 doi "https://doi.org/10.1021/cen-10004-newscripts" @default.
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