Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210439779> ?p ?o ?g. }
- W4210439779 endingPage "251" @default.
- W4210439779 startingPage "242" @default.
- W4210439779 abstract "Malignant mesothelioma (MM) is still increasing worldwide. The pathogenesis depends on asbestos-induced iron accumulation, which eventually leads to ferroptosis-resistance of mesothelial cells via somatic mutations. Poly (rC)-binding proteins 1 and 2 (PCBP1/2) are recently recognized cytosolic Fe(II) chaperones. Here we studied the role of PCBP1/2 in rat/human mesothelial and MM cells as well as rat/human MM specimens. Normal peritoneal mesothelial cells in rats exhibited PCBP1 but not PCBP2 immunopositivity whereas primary/immortalized mesothelial cells showed PCBP1/2 immunopositivity. Rat MM specimens induced by intraperitoneal injection of chrysotile, including in situ lesion, revealed PCBP1/2 immunopositivity (90% for both) in the nucleus and cytoplasm with a tendency of higher expression in epithelioid subtype. Knockdown of PCBP2 but not PCBP1 significantly decreased both TfR1 and FTH expression in MM cells with inhibition of proliferation, indicating stagnation of intracellular iron transport. Erastin, a cysteine-deprivation type ferroptosis inducer, decreased the expression of both PCBP1/2 in MM cells. Furthermore, PCBP2 knockdown significantly increased the sensitivity of MM cells to erastin-induced ferroptosis with increased catalytic Fe(II). In conclusion, PCBP2 works for ferroptosis-resistance not only during mesothelial carcinogenesis but also in MM, which warrants further investigation as a novel therapeutic target." @default.
- W4210439779 created "2022-02-08" @default.
- W4210439779 creator A5004669931 @default.
- W4210439779 creator A5011918761 @default.
- W4210439779 creator A5022244759 @default.
- W4210439779 creator A5038749740 @default.
- W4210439779 creator A5051782587 @default.
- W4210439779 date "2022-01-28" @default.
- W4210439779 modified "2023-10-17" @default.
- W4210439779 title "PCBP2 knockdown promotes ferroptosis in malignant mesothelioma" @default.
- W4210439779 cites W1932495143 @default.
- W4210439779 cites W1967423388 @default.
- W4210439779 cites W1971170437 @default.
- W4210439779 cites W1984749304 @default.
- W4210439779 cites W1996152690 @default.
- W4210439779 cites W2008883395 @default.
- W4210439779 cites W2021660655 @default.
- W4210439779 cites W2027443731 @default.
- W4210439779 cites W2028034405 @default.
- W4210439779 cites W2033559223 @default.
- W4210439779 cites W2037217405 @default.
- W4210439779 cites W2052033385 @default.
- W4210439779 cites W2059993615 @default.
- W4210439779 cites W2063059327 @default.
- W4210439779 cites W2085043000 @default.
- W4210439779 cites W2085610369 @default.
- W4210439779 cites W2098270395 @default.
- W4210439779 cites W2108769238 @default.
- W4210439779 cites W2112844455 @default.
- W4210439779 cites W2136889940 @default.
- W4210439779 cites W2137319242 @default.
- W4210439779 cites W2162401636 @default.
- W4210439779 cites W2163609588 @default.
- W4210439779 cites W2174098335 @default.
- W4210439779 cites W2426081542 @default.
- W4210439779 cites W2724653687 @default.
- W4210439779 cites W2762087180 @default.
- W4210439779 cites W2790509939 @default.
- W4210439779 cites W2797147302 @default.
- W4210439779 cites W2808373517 @default.
- W4210439779 cites W2884202833 @default.
- W4210439779 cites W2888053910 @default.
- W4210439779 cites W2891299437 @default.
- W4210439779 cites W2896335047 @default.
- W4210439779 cites W2897032853 @default.
- W4210439779 cites W3027650570 @default.
- W4210439779 cites W3037322823 @default.
- W4210439779 cites W3040903615 @default.
- W4210439779 cites W3042866397 @default.
- W4210439779 cites W3092311154 @default.
- W4210439779 cites W3102629870 @default.
- W4210439779 cites W3125391706 @default.
- W4210439779 cites W3161341716 @default.
- W4210439779 cites W3177874667 @default.
- W4210439779 cites W3205584884 @default.
- W4210439779 cites W3208148345 @default.
- W4210439779 cites W3208325566 @default.
- W4210439779 doi "https://doi.org/10.1111/pin.13209" @default.
- W4210439779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35089637" @default.
- W4210439779 hasPublicationYear "2022" @default.
- W4210439779 type Work @default.
- W4210439779 citedByCount "7" @default.
- W4210439779 countsByYear W42104397792022 @default.
- W4210439779 countsByYear W42104397792023 @default.
- W4210439779 crossrefType "journal-article" @default.
- W4210439779 hasAuthorship W4210439779A5004669931 @default.
- W4210439779 hasAuthorship W4210439779A5011918761 @default.
- W4210439779 hasAuthorship W4210439779A5022244759 @default.
- W4210439779 hasAuthorship W4210439779A5038749740 @default.
- W4210439779 hasAuthorship W4210439779A5051782587 @default.
- W4210439779 hasBestOaLocation W42104397791 @default.
- W4210439779 hasConcept C104317684 @default.
- W4210439779 hasConcept C142724271 @default.
- W4210439779 hasConcept C153911025 @default.
- W4210439779 hasConcept C173396325 @default.
- W4210439779 hasConcept C185592680 @default.
- W4210439779 hasConcept C190062978 @default.
- W4210439779 hasConcept C190283241 @default.
- W4210439779 hasConcept C2777407522 @default.
- W4210439779 hasConcept C2779747549 @default.
- W4210439779 hasConcept C2780942790 @default.
- W4210439779 hasConcept C2909640154 @default.
- W4210439779 hasConcept C502942594 @default.
- W4210439779 hasConcept C55493867 @default.
- W4210439779 hasConcept C555283112 @default.
- W4210439779 hasConcept C71924100 @default.
- W4210439779 hasConcept C86803240 @default.
- W4210439779 hasConcept C95444343 @default.
- W4210439779 hasConceptScore W4210439779C104317684 @default.
- W4210439779 hasConceptScore W4210439779C142724271 @default.
- W4210439779 hasConceptScore W4210439779C153911025 @default.
- W4210439779 hasConceptScore W4210439779C173396325 @default.
- W4210439779 hasConceptScore W4210439779C185592680 @default.
- W4210439779 hasConceptScore W4210439779C190062978 @default.
- W4210439779 hasConceptScore W4210439779C190283241 @default.
- W4210439779 hasConceptScore W4210439779C2777407522 @default.
- W4210439779 hasConceptScore W4210439779C2779747549 @default.
- W4210439779 hasConceptScore W4210439779C2780942790 @default.