FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210454911> ?p ?o ?g. }

• W4210454911 endingPage "1859" @default.
• W4210454911 startingPage "1846" @default.
• W4210454911 abstract "The liver is the primary organ for frontline immune defense and lipid metabolism. Excessive lipid accumulation in the liver severely affects its metabolic homeostasis and causes metabolic diseases. Docosahexaenoic acid (DHA) is known for its beneficial effects on lipid metabolism and anti-inflammation, but its molecular mechanism remains unknown, especially in fish. In this study, we evaluated the protective effects of DHA on hepatic steatosis of grass carp (Ctenopharyngodon idella) in vivo and in vitro and mainly focused on the AMP-activated protein kinase (AMPK) and endoplasmic reticulum stress (ER stress) signaling pathway analysis. Grass carp were fed with purified diets supplemented with 0%, 0.5% and 1% DHA for 8 weeks in vivo. 1% DHA supplementation significantly decreased the liver triglyceride (TG), malondialdehyde (MDA), serum tumor necrosis factor α (TNFα) and nuclear factor kappa B (NFκB) contents. DHA administration suppressed ER stress and decreased the mRNA expressions related to hepatic inflammation and lipogenesis, accompanied by the activation of AMPK. Correspondingly, DHA activated the AMPK signaling pathway, and inhibited palmitic acid (PA)-evoked ER stress and lipid accumulation and inflammation of grass carp hepatocytes in vitro. In contrast, the inhibitor of AMPK (compound C, CC) abrogated the effects of DHA to improve PA-induced liver injury and ER stress. In conclusion, DHA inhibits ER stress in hepatocytes by the activation of AMPK and exerts protective effects on hepatic steatosis in terms of improving antioxidant ability, relieving hepatic inflammation and inhibiting hepatic lipogenesis. Our findings give a theoretical foundation for further elucidation of the beneficial role of DHA in vertebrates." @default.
• W4210454911 created "2022-02-08" @default.
• W4210454911 creator A5032240410 @default.
• W4210454911 creator A5047936031 @default.
• W4210454911 creator A5053577359 @default.
• W4210454911 creator A5058095489 @default.
• W4210454911 creator A5080731377 @default.
• W4210454911 date "2022-01-01" @default.
• W4210454911 modified "2023-10-02" @default.
• W4210454911 title "Docosahexaenoic acid lessens hepatic lipid accumulation and inflammation <i>via</i> the AMP-activated protein kinase and endoplasmic reticulum stress signaling pathways in grass carp (<i>Ctenopharyngodon idella</i>)" @default.
• W4210454911 cites W1820959305 @default.
• W4210454911 cites W1821741216 @default.
• W4210454911 cites W1863611356 @default.
• W4210454911 cites W1866375022 @default.
• W4210454911 cites W1889359478 @default.
• W4210454911 cites W1908780918 @default.
• W4210454911 cites W1979422557 @default.
• W4210454911 cites W1983167131 @default.
• W4210454911 cites W1985478480 @default.
• W4210454911 cites W1985592156 @default.
• W4210454911 cites W1994142435 @default.
• W4210454911 cites W1997901667 @default.
• W4210454911 cites W2011574523 @default.
• W4210454911 cites W2026414944 @default.
• W4210454911 cites W2029115838 @default.
• W4210454911 cites W2035301605 @default.
• W4210454911 cites W2039527621 @default.
• W4210454911 cites W2045541868 @default.
• W4210454911 cites W2061864595 @default.
• W4210454911 cites W2089108588 @default.
• W4210454911 cites W2092723309 @default.
• W4210454911 cites W2093273210 @default.
• W4210454911 cites W2104808461 @default.
• W4210454911 cites W2108244474 @default.
• W4210454911 cites W2111045432 @default.
• W4210454911 cites W2122024003 @default.
• W4210454911 cites W2126626992 @default.
• W4210454911 cites W2129125398 @default.
• W4210454911 cites W2131094572 @default.
• W4210454911 cites W2137926031 @default.
• W4210454911 cites W2213439730 @default.
• W4210454911 cites W2214341650 @default.
• W4210454911 cites W2297226684 @default.
• W4210454911 cites W2335443960 @default.
• W4210454911 cites W2338367701 @default.
• W4210454911 cites W2467091785 @default.
• W4210454911 cites W2591646528 @default.
• W4210454911 cites W2602394003 @default.
• W4210454911 cites W2610366065 @default.
• W4210454911 cites W2625079416 @default.
• W4210454911 cites W2736113113 @default.
• W4210454911 cites W2749774408 @default.
• W4210454911 cites W2755785399 @default.
• W4210454911 cites W2810166530 @default.
• W4210454911 cites W2889843279 @default.
• W4210454911 cites W2910854646 @default.
• W4210454911 cites W2924159270 @default.
• W4210454911 cites W2947284075 @default.
• W4210454911 cites W2952582160 @default.
• W4210454911 cites W2973167612 @default.
• W4210454911 cites W2973408003 @default.
• W4210454911 cites W2975025207 @default.
• W4210454911 cites W2996445414 @default.
• W4210454911 cites W3006804227 @default.
• W4210454911 cites W3045443779 @default.
• W4210454911 cites W3087288597 @default.
• W4210454911 cites W3111751491 @default.
• W4210454911 cites W3113365972 @default.
• W4210454911 cites W3161662437 @default.
• W4210454911 doi "https://doi.org/10.1039/d1fo03214c" @default.
• W4210454911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35084424" @default.
• W4210454911 hasPublicationYear "2022" @default.
• W4210454911 type Work @default.
• W4210454911 citedByCount "4" @default.
• W4210454911 countsByYear W42104549112023 @default.
• W4210454911 crossrefType "journal-article" @default.
• W4210454911 hasAuthorship W4210454911A5032240410 @default.
• W4210454911 hasAuthorship W4210454911A5047936031 @default.
• W4210454911 hasAuthorship W4210454911A5053577359 @default.
• W4210454911 hasAuthorship W4210454911A5058095489 @default.
• W4210454911 hasAuthorship W4210454911A5080731377 @default.
• W4210454911 hasBestOaLocation W42104549112 @default.
• W4210454911 hasConcept C126322002 @default.
• W4210454911 hasConcept C134018914 @default.
• W4210454911 hasConcept C139447449 @default.
• W4210454911 hasConcept C141359234 @default.
• W4210454911 hasConcept C158617107 @default.
• W4210454911 hasConcept C184235292 @default.
• W4210454911 hasConcept C185592680 @default.
• W4210454911 hasConcept C19038510 @default.
• W4210454911 hasConcept C2776175330 @default.
• W4210454911 hasConcept C2776780712 @default.
• W4210454911 hasConcept C2776914184 @default.
• W4210454911 hasConcept C2777171753 @default.
• W4210454911 hasConcept C2780124434 @default.
• W4210454911 hasConcept C2781257293 @default.
• W4210454911 hasConcept C2909208804 @default.
• W4210454911 hasConcept C4733338 @default.

• next