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- W4210461633 abstract "BACKGROUND: Motor-related brain activity in Parkinson's disease has been investigated in a multitude of functional neuroimaging studies, which often yielded apparently conflicting results. Our previous meta-analysis did not resolve inconsistencies regarding cortical activation differences in Parkinson's disease, which might be related to the limited number of studies that could be included. Therefore, we conducted a revised meta-analysis including a larger number of studies. The objectives of this study were to elucidate brain areas that consistently show abnormal motor-related activation in Parkinson's disease and to reveal their functional connectivity profiles using meta-analytic approaches.METHODS: We applied a quantitative meta-analysis of functional neuroimaging studies testing limb movements in Parkinson's disease comprising data from 39 studies, of which 15 studies (285 of 571 individual patients) were published after the previous meta-analysis. We also conducted meta-analytic connectivity modeling to elucidate the connectivity profiles of areas showing abnormal activation.RESULTS: We found consistent motor-related underactivation of bilateral posterior putamen and cerebellum in Parkinson's disease. Primary motor cortex and the supplementary motor area also showed deficient activation, whereas cortical regions localized directly anterior to these areas expressed overactivation. Connectivity modeling revealed that areas showing decreased activation shared a common pathway through the posterior putamen, whereas areas showing increased activation were connected to the anterior putamen.CONCLUSIONS: Despite conflicting results in individual neuroimaging studies, this revised meta-analytic approach identified consistent patterns of abnormal motor-related activation in Parkinson's disease. The distinct patterns of decreased and increased activity might be determined by their connectivity with different subregions of the putamen. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.© 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. PMID: 33427336 Funding information This work was supported by: Helmholtz Portfolio Theme Supercomputing and Modeling for the Human Brain, NovoNordisk foundation, Grant ID: NNF16OC0023090 NIMH NIH HHS, United States Grant ID: R01 MH074457 European Union's Horizon 2020 Research and Innovation Programme, Grant ID: 945539 Independent Research Fund Denmark, Grant ID: 0168-00014B Lundbeck Foundation, Grant ID: R186-2015-2138 NIMH NIH HHS, United States Grant ID: R01-MH074457 More Less keyboard_arrow_down" @default.
- W4210461633 created "2022-02-08" @default.
- W4210461633 creator A5081329835 @default.
- W4210461633 date "2021-01-14" @default.
- W4210461633 modified "2023-09-23" @default.
- W4210461633 title "Faculty Opinions recommendation of Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling." @default.
- W4210461633 doi "https://doi.org/10.3410/f.739348078.793581864" @default.
- W4210461633 hasPublicationYear "2021" @default.
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