Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210463301> ?p ?o ?g. }
- W4210463301 endingPage "709" @default.
- W4210463301 startingPage "701" @default.
- W4210463301 abstract "Several studies support associations between relative leukocyte telomere length (rLTL), a biomarker of biological aging and type 2 diabetes. This study investigates the relationship between rLTL and the risk of glycemic progression in patients with type 2 diabetes.In this cohort study, consecutive Chinese patients with type 2 diabetes (N = 5,506) from the Hong Kong Diabetes Register with stored baseline DNA and available follow-up data were studied. rLTL was measured using quantitative PCR. Glycemic progression was defined as the new need for exogenous insulin.The mean (SD) age of the 5,349 subjects was 57.0 (13.3) years, and mean (SD) follow-up was 8.8 (5.4) years. Baseline rLTL was significantly shorter in the 1,803 subjects who progressed to insulin requirement compared with the remaining subjects (4.43 ± 1.16 vs. 4.69 ± 1.20). Shorter rLTL was associated with a higher risk of glycemic progression (hazard ratio [95% CI] for each unit decrease [to ∼0.2 kilobases]: 1.10 [1.06-1.14]), which remained significant after adjusting for confounders. Baseline rLTL was independently associated with glycemic exposure during follow-up (β = -0.05 [-0.06 to -0.04]). Each 1-kilobase decrease in absolute LTL was on average associated with a 1.69-fold higher risk of diabetes progression (95% CI 1.35-2.11). Two-sample Mendelian randomization analysis showed per 1-unit genetically decreased rLTL was associated with a 1.38-fold higher risk of diabetes progression (95% CI 1.12-1.70).Shorter rLTL was significantly associated with an increased risk of glycemic progression in individuals with type 2 diabetes, independent of established risk factors. Telomere length may be a useful biomarker for glycemic progression in people with type 2 diabetes." @default.
- W4210463301 created "2022-02-08" @default.
- W4210463301 creator A5000486450 @default.
- W4210463301 creator A5007921065 @default.
- W4210463301 creator A5011948462 @default.
- W4210463301 creator A5015293558 @default.
- W4210463301 creator A5017135264 @default.
- W4210463301 creator A5020273125 @default.
- W4210463301 creator A5021394512 @default.
- W4210463301 creator A5022468819 @default.
- W4210463301 creator A5023590941 @default.
- W4210463301 creator A5027757155 @default.
- W4210463301 creator A5031397097 @default.
- W4210463301 creator A5037855971 @default.
- W4210463301 creator A5040544030 @default.
- W4210463301 creator A5042790119 @default.
- W4210463301 creator A5046780929 @default.
- W4210463301 creator A5064838541 @default.
- W4210463301 creator A5071861422 @default.
- W4210463301 creator A5073188505 @default.
- W4210463301 creator A5077397829 @default.
- W4210463301 creator A5078794423 @default.
- W4210463301 creator A5080234368 @default.
- W4210463301 creator A5080813523 @default.
- W4210463301 creator A5081052339 @default.
- W4210463301 creator A5084428223 @default.
- W4210463301 creator A5084593588 @default.
- W4210463301 creator A5087611874 @default.
- W4210463301 date "2022-01-27" @default.
- W4210463301 modified "2023-10-18" @default.
- W4210463301 title "Shortened Leukocyte Telomere Length Is Associated With Glycemic Progression in Type 2 Diabetes: A Prospective and Mendelian Randomization Analysis" @default.
- W4210463301 cites W1491165075 @default.
- W4210463301 cites W1969081944 @default.
- W4210463301 cites W1981775109 @default.
- W4210463301 cites W1984707167 @default.
- W4210463301 cites W2003346248 @default.
- W4210463301 cites W2055456315 @default.
- W4210463301 cites W2094747857 @default.
- W4210463301 cites W2095722096 @default.
- W4210463301 cites W2100442315 @default.
- W4210463301 cites W2102044378 @default.
- W4210463301 cites W2104787190 @default.
- W4210463301 cites W2118331177 @default.
- W4210463301 cites W2136102567 @default.
- W4210463301 cites W2137638424 @default.
- W4210463301 cites W2160621707 @default.
- W4210463301 cites W2165792590 @default.
- W4210463301 cites W2166300968 @default.
- W4210463301 cites W2167048252 @default.
- W4210463301 cites W2168228291 @default.
- W4210463301 cites W2270568241 @default.
- W4210463301 cites W2319845284 @default.
- W4210463301 cites W2405977822 @default.
- W4210463301 cites W2535658226 @default.
- W4210463301 cites W2599190942 @default.
- W4210463301 cites W2948278421 @default.
- W4210463301 cites W3014311558 @default.
- W4210463301 cites W3042406528 @default.
- W4210463301 cites W3045623812 @default.
- W4210463301 cites W3084920978 @default.
- W4210463301 cites W3109121741 @default.
- W4210463301 cites W3204811749 @default.
- W4210463301 cites W3216968075 @default.
- W4210463301 cites W36168761 @default.
- W4210463301 doi "https://doi.org/10.2337/dc21-1609" @default.
- W4210463301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35085380" @default.
- W4210463301 hasPublicationYear "2022" @default.
- W4210463301 type Work @default.
- W4210463301 citedByCount "20" @default.
- W4210463301 countsByYear W42104633012021 @default.
- W4210463301 countsByYear W42104633012022 @default.
- W4210463301 countsByYear W42104633012023 @default.
- W4210463301 crossrefType "journal-article" @default.
- W4210463301 hasAuthorship W4210463301A5000486450 @default.
- W4210463301 hasAuthorship W4210463301A5007921065 @default.
- W4210463301 hasAuthorship W4210463301A5011948462 @default.
- W4210463301 hasAuthorship W4210463301A5015293558 @default.
- W4210463301 hasAuthorship W4210463301A5017135264 @default.
- W4210463301 hasAuthorship W4210463301A5020273125 @default.
- W4210463301 hasAuthorship W4210463301A5021394512 @default.
- W4210463301 hasAuthorship W4210463301A5022468819 @default.
- W4210463301 hasAuthorship W4210463301A5023590941 @default.
- W4210463301 hasAuthorship W4210463301A5027757155 @default.
- W4210463301 hasAuthorship W4210463301A5031397097 @default.
- W4210463301 hasAuthorship W4210463301A5037855971 @default.
- W4210463301 hasAuthorship W4210463301A5040544030 @default.
- W4210463301 hasAuthorship W4210463301A5042790119 @default.
- W4210463301 hasAuthorship W4210463301A5046780929 @default.
- W4210463301 hasAuthorship W4210463301A5064838541 @default.
- W4210463301 hasAuthorship W4210463301A5071861422 @default.
- W4210463301 hasAuthorship W4210463301A5073188505 @default.
- W4210463301 hasAuthorship W4210463301A5077397829 @default.
- W4210463301 hasAuthorship W4210463301A5078794423 @default.
- W4210463301 hasAuthorship W4210463301A5080234368 @default.
- W4210463301 hasAuthorship W4210463301A5080813523 @default.
- W4210463301 hasAuthorship W4210463301A5081052339 @default.
- W4210463301 hasAuthorship W4210463301A5084428223 @default.
- W4210463301 hasAuthorship W4210463301A5084593588 @default.