FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210476699> ?p ?o ?g. }

• W4210476699 abstract "Early life stress (ELS) disposes to functional gastrointestinal diseases in adult, such as irritable bowel syndrome (IBS). Maternal separation (MS) is a well-known animal model of IBS and has been shown to induce visceral hypersensitivity in adult rats and mice. However, to the best of our knowledge, it has not been reported whether MS induces visceral hypersensitivity in young mice, such as the post-weaning mice. Moreover, the method for evaluation of visceral sensitivity also has not been described. Accordingly, the present study aims to evaluate the visceral sensitivity caused by MS in post-weaning mice and develop a novel and small size distention balloon for assessment of visceral sensitivity of such mice. Male pups of C57BL/6 mice were randomly divided into two groups, MS (n = 12) and non-separation (NS) (n = 10). MS pups were separated from the dams through postnatal days (PND) 2 to 14, while NS pups were undisturbed. After, all pups stayed with respective dams and were weaned at PND 22. Visceral sensitivity was evaluated by colorectal distention (CRD) with a novel and small size distention balloon at PND 25. The threshold of abdominal withdrawal reflex (AWR) scores were significantly lower in MS than NS. In addition, AWR scores at different pressures of CRD were significantly higher in MS than NS. The results demonstrate that MS induced visceral hypersensitivity in post-weaning mice. The designed small size distention balloon for evaluation of visceral sensitivity is of significance to further study the pathophysiology of IBS from early life to adulthood." @default.
• W4210476699 created "2022-02-08" @default.
• W4210476699 creator A5014975219 @default.
• W4210476699 creator A5026417516 @default.
• W4210476699 creator A5041072711 @default.
• W4210476699 creator A5046702276 @default.
• W4210476699 creator A5047350019 @default.
• W4210476699 creator A5067483347 @default.
• W4210476699 creator A5067820116 @default.
• W4210476699 creator A5068595169 @default.
• W4210476699 date "2022-01-28" @default.
• W4210476699 modified "2023-10-18" @default.
• W4210476699 title "Maternal Separation Induced Visceral Hypersensitivity Evaluated via Novel and Small Size Distention Balloon in Post-weaning Mice" @default.
• W4210476699 cites W1651663774 @default.
• W4210476699 cites W1949635207 @default.
• W4210476699 cites W1966160259 @default.
• W4210476699 cites W1970485479 @default.
• W4210476699 cites W1973233423 @default.
• W4210476699 cites W1985243765 @default.
• W4210476699 cites W1995250682 @default.
• W4210476699 cites W1997774819 @default.
• W4210476699 cites W2002184042 @default.
• W4210476699 cites W2011914193 @default.
• W4210476699 cites W2042371226 @default.
• W4210476699 cites W2042423362 @default.
• W4210476699 cites W2068983334 @default.
• W4210476699 cites W2078271439 @default.
• W4210476699 cites W2079464767 @default.
• W4210476699 cites W2088450404 @default.
• W4210476699 cites W2096091483 @default.
• W4210476699 cites W2100379122 @default.
• W4210476699 cites W2110240525 @default.
• W4210476699 cites W2119084734 @default.
• W4210476699 cites W2158380688 @default.
• W4210476699 cites W2165284393 @default.
• W4210476699 cites W2166102321 @default.
• W4210476699 cites W2209096888 @default.
• W4210476699 cites W2231115651 @default.
• W4210476699 cites W2290190425 @default.
• W4210476699 cites W2344997643 @default.
• W4210476699 cites W2482083953 @default.
• W4210476699 cites W2494623578 @default.
• W4210476699 cites W2505300434 @default.
• W4210476699 cites W2548933161 @default.
• W4210476699 cites W2565773508 @default.
• W4210476699 cites W2593821530 @default.
• W4210476699 cites W2612628423 @default.
• W4210476699 cites W2617612172 @default.
• W4210476699 cites W2624678362 @default.
• W4210476699 cites W2752878443 @default.
• W4210476699 cites W2805096634 @default.
• W4210476699 cites W2807967613 @default.
• W4210476699 cites W2896293926 @default.
• W4210476699 cites W2906104869 @default.
• W4210476699 cites W2921510018 @default.
• W4210476699 cites W2939219611 @default.
• W4210476699 cites W2954098374 @default.
• W4210476699 cites W2971234988 @default.
• W4210476699 cites W3001992982 @default.
• W4210476699 cites W3004162423 @default.
• W4210476699 cites W3008887081 @default.
• W4210476699 cites W3012264031 @default.
• W4210476699 cites W3019278566 @default.
• W4210476699 cites W3026047770 @default.
• W4210476699 cites W3027180652 @default.
• W4210476699 cites W3042584357 @default.
• W4210476699 cites W3120509161 @default.
• W4210476699 cites W3139480415 @default.
• W4210476699 cites W3165491310 @default.
• W4210476699 doi "https://doi.org/10.3389/fnins.2021.803957" @default.
• W4210476699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35153662" @default.
• W4210476699 hasPublicationYear "2022" @default.
• W4210476699 type Work @default.
• W4210476699 citedByCount "5" @default.
• W4210476699 countsByYear W42104766992022 @default.
• W4210476699 countsByYear W42104766992023 @default.
• W4210476699 crossrefType "journal-article" @default.
• W4210476699 hasAuthorship W4210476699A5014975219 @default.
• W4210476699 hasAuthorship W4210476699A5026417516 @default.
• W4210476699 hasAuthorship W4210476699A5041072711 @default.
• W4210476699 hasAuthorship W4210476699A5046702276 @default.
• W4210476699 hasAuthorship W4210476699A5047350019 @default.
• W4210476699 hasAuthorship W4210476699A5067483347 @default.
• W4210476699 hasAuthorship W4210476699A5067820116 @default.
• W4210476699 hasAuthorship W4210476699A5068595169 @default.
• W4210476699 hasBestOaLocation W42104766991 @default.
• W4210476699 hasConcept C10162356 @default.
• W4210476699 hasConcept C126322002 @default.
• W4210476699 hasConcept C139059822 @default.
• W4210476699 hasConcept C15490471 @default.
• W4210476699 hasConcept C170493617 @default.
• W4210476699 hasConcept C195512701 @default.
• W4210476699 hasConcept C2778271842 @default.
• W4210476699 hasConcept C2779794527 @default.
• W4210476699 hasConcept C2780655333 @default.
• W4210476699 hasConcept C42219234 @default.
• W4210476699 hasConcept C71924100 @default.
• W4210476699 hasConcept C83974742 @default.
• W4210476699 hasConcept C90924648 @default.
• W4210476699 hasConceptScore W4210476699C10162356 @default.

• next