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• W4210492032 endingPage "693" @default.
• W4210492032 startingPage "693" @default.
• W4210492032 abstract "Thermal ablation is a definitive local treatment for selected colorectal liver metastases (CLM) that can be ablated with adequate margins. A critical limitation has been local tumor progression (LTP).This prospective, single-group, phase 2 study enrolled patients with CLM < 5 cm in maximum diameter, at a tertiary cancer center between November 2009 and February 2019. Biopsy of the ablation zone center and margin was performed immediately after ablation. Viable tumor in tissue biopsy and ablation margins < 5 mm were assessed as predictors of 12-month LTP.We enrolled 107 patients with 182 CLMs. Mean tumor size was 2.0 (range, 0.6-4.6) cm. Microwave ablation was used in 51% and radiofrequency ablation in 49% of tumors. The 12- and 24-month cumulative incidence of LTP was 22% (95% confidence interval [CI]: 17, 29) and 29% (95% CI: 23, 36), respectively. LTP at 12 months was 7% (95% CI: 3, 14) for the biopsy tumor-negative ablation zone with margins ≥ 5 mm vs. 63% (95% CI: 35, 85) for the biopsy-positive ablation zone with margins < 5 mm (p < 0.001).Biopsy-proven complete tumor ablation with margins of at least 5 mm achieves optimal local tumor control for CLM, regardless of the ablation modality used." @default.
• W4210492032 created "2022-02-08" @default.
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• W4210492032 date "2022-01-29" @default.
• W4210492032 modified "2023-09-26" @default.
• W4210492032 title "Biopsy and Margins Optimize Outcomes after Thermal Ablation of Colorectal Liver Metastases" @default.
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• W4210492032 doi "https://doi.org/10.3390/cancers14030693" @default.
• W4210492032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35158963" @default.
• W4210492032 hasPublicationYear "2022" @default.
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