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- W4210492044 abstract "Abstract The ability to respond flexibly to an ever-changing environment relies on the orbitofrontal cortex (OFC). How the OFC associates sensory information with predicted outcomes to enable flexible sensory learning in humans remains elusive. Here, we combine a probabilistic tactile reversal learning task with functional magnetic resonance imaging (fMRI) to investigate how lateral OFC (lOFC) interacts with the primary somatosensory cortex (S1) to guide flexible tactile learning in humans. fMRI results reveal that lOFC and S1 exhibit distinct task-dependent engagement: while the lOFC responds transiently to unexpected outcomes immediately following reversals, S1 is persistently engaged during re-learning. Unlike the contralateral stimulus-responsive S1, activity in ipsilateral S1 mirrors the outcomes of behavior during re-learning, which is closely related to top-down signals from lOFC. These findings suggest that lOFC contributes to teaching signals to dynamically update representations in sensory areas, which implements computations critical for adaptive behavior." @default.
- W4210492044 created "2022-02-08" @default.
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- W4210492044 date "2022-02-04" @default.
- W4210492044 modified "2023-09-26" @default.
- W4210492044 title "Human orbitofrontal cortex signals decision outcomes to sensory cortex during flexible tactile learning" @default.
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- W4210492044 doi "https://doi.org/10.1101/2022.02.02.478729" @default.
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