FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210496898> ?p ?o ?g. }

• W4210496898 abstract "Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric posterior circulation. We here determined whether these sex-specific brain manifestations also affect long-term outcomes. We relied on 822 acute ischaemic patients [age: 64.7 (15.0) years, 39% women] originating from the multi-centre MRI-GENIE study to model unfavourable outcomes (modified Rankin Scale >2) based on acute neuroimaging data in a Bayesian hierarchical framework. Lesions encompassing bilateral subcortical nuclei and left-lateralized regions in proximity to the insula explained outcomes across men and women (area under the curve = 0.81). A pattern of left-hemispheric posterior circulation brain regions, combining left hippocampus, precuneus, fusiform and lingual gyrus, occipital pole and latero-occipital cortex, showed a substantially higher relevance in explaining functional outcomes in women compared to men [mean difference of Bayesian posterior distributions (men - women) = -0.295 (90% highest posterior density interval = -0.556 to -0.068)]. Once validated in prospective studies, our findings may motivate a sex-specific approach to clinical stroke management and hold the promise of enhancing outcomes on a population level." @default.
• W4210496898 created "2022-02-08" @default.
• W4210496898 creator A5001592746 @default.
• W4210496898 creator A5004416193 @default.
• W4210496898 creator A5006245302 @default.
• W4210496898 creator A5006664647 @default.
• W4210496898 creator A5010029432 @default.
• W4210496898 creator A5010722813 @default.
• W4210496898 creator A5014671077 @default.
• W4210496898 creator A5015843495 @default.
• W4210496898 creator A5016216017 @default.
• W4210496898 creator A5021332109 @default.
• W4210496898 creator A5023456800 @default.
• W4210496898 creator A5023712442 @default.
• W4210496898 creator A5024045298 @default.
• W4210496898 creator A5026053527 @default.
• W4210496898 creator A5026734876 @default.
• W4210496898 creator A5028166003 @default.
• W4210496898 creator A5030896311 @default.
• W4210496898 creator A5033337810 @default.
• W4210496898 creator A5036911759 @default.
• W4210496898 creator A5037104689 @default.
• W4210496898 creator A5037728234 @default.
• W4210496898 creator A5037930891 @default.
• W4210496898 creator A5039943736 @default.
• W4210496898 creator A5043364843 @default.
• W4210496898 creator A5044028607 @default.
• W4210496898 creator A5045527733 @default.
• W4210496898 creator A5049405504 @default.
• W4210496898 creator A5050205623 @default.
• W4210496898 creator A5051587217 @default.
• W4210496898 creator A5051664900 @default.
• W4210496898 creator A5053331577 @default.
• W4210496898 creator A5054334158 @default.
• W4210496898 creator A5058424153 @default.
• W4210496898 creator A5058666819 @default.
• W4210496898 creator A5058988118 @default.
• W4210496898 creator A5059434182 @default.
• W4210496898 creator A5060494279 @default.
• W4210496898 creator A5060649078 @default.
• W4210496898 creator A5060878215 @default.
• W4210496898 creator A5061020099 @default.
• W4210496898 creator A5061275743 @default.
• W4210496898 creator A5061474894 @default.
• W4210496898 creator A5062194357 @default.
• W4210496898 creator A5064334744 @default.
• W4210496898 creator A5064825668 @default.
• W4210496898 creator A5066195949 @default.
• W4210496898 creator A5071151925 @default.
• W4210496898 creator A5071188109 @default.
• W4210496898 creator A5071627467 @default.
• W4210496898 creator A5075559225 @default.
• W4210496898 creator A5075877585 @default.
• W4210496898 creator A5077333999 @default.
• W4210496898 creator A5080158732 @default.
• W4210496898 creator A5082357886 @default.
• W4210496898 creator A5085144463 @default.
• W4210496898 creator A5086723819 @default.
• W4210496898 creator A5089540833 @default.
• W4210496898 creator A5090081544 @default.
• W4210496898 creator A5091409910 @default.
• W4210496898 creator A5091678814 @default.
• W4210496898 date "2022-02-02" @default.
• W4210496898 modified "2023-10-16" @default.
• W4210496898 title "Sex-specific lesion pattern of functional outcomes after stroke" @default.
• W4210496898 cites W2008209982 @default.
• W4210496898 cites W2044393202 @default.
• W4210496898 cites W2067456724 @default.
• W4210496898 cites W2077869855 @default.
• W4210496898 cites W2097076392 @default.
• W4210496898 cites W2101135654 @default.
• W4210496898 cites W2130461216 @default.
• W4210496898 cites W2140713107 @default.
• W4210496898 cites W2153813326 @default.
• W4210496898 cites W2153857579 @default.
• W4210496898 cites W2217402295 @default.
• W4210496898 cites W2296621543 @default.
• W4210496898 cites W2747301517 @default.
• W4210496898 cites W2803802119 @default.
• W4210496898 cites W2808037193 @default.
• W4210496898 cites W2902923903 @default.
• W4210496898 cites W2915941435 @default.
• W4210496898 cites W2950669388 @default.
• W4210496898 cites W2951617899 @default.
• W4210496898 cites W2965440752 @default.
• W4210496898 cites W2965700737 @default.
• W4210496898 cites W2987647138 @default.
• W4210496898 cites W2990159029 @default.
• W4210496898 cites W3037384956 @default.
• W4210496898 cites W3121452939 @default.
• W4210496898 cites W3122475326 @default.
• W4210496898 cites W3133373927 @default.
• W4210496898 cites W3164978977 @default.
• W4210496898 cites W3165123812 @default.
• W4210496898 cites W4220928642 @default.
• W4210496898 cites W4295750005 @default.
• W4210496898 doi "https://doi.org/10.1093/braincomms/fcac020" @default.
• W4210496898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35282166" @default.
• W4210496898 hasPublicationYear "2022" @default.
• W4210496898 type Work @default.

• next