Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210497624> ?p ?o ?g. }
- W4210497624 endingPage "1477" @default.
- W4210497624 startingPage "1477" @default.
- W4210497624 abstract "Endothelial cells throughout the body are heterogeneous, and this is tightly linked to the specific functions of organs and tissues. Heterogeneity is already determined from development onwards and ranges from arterial/venous specification to microvascular fate determination in organ-specific differentiation. Acknowledging the different phenotypes of endothelial cells and the implications of this diversity is key for the development of more specialized tissue engineering and vascular repair approaches. However, although novel technologies in transcriptomics and proteomics are facilitating the unraveling of vascular bed-specific endothelial cell signatures, still much research is based on the use of insufficiently specialized endothelial cells. Endothelial cells are not only heterogeneous, but their specialized phenotypes are also dynamic and adapt to changes in their microenvironment. During the last decades, strong collaborations between molecular biology, mechanobiology, and computational disciplines have led to a better understanding of how endothelial cells are modulated by their mechanical and biochemical contexts. Yet, because of the use of insufficiently specialized endothelial cells, there is still a huge lack of knowledge in how tissue-specific biomechanical factors determine organ-specific phenotypes. With this review, we want to put the focus on how organ-specific endothelial cell signatures are determined from development onwards and conditioned by their microenvironments during adulthood. We discuss the latest research performed on endothelial cells, pointing out the important implications of mimicking tissue-specific biomechanical cues in culture." @default.
- W4210497624 created "2022-02-08" @default.
- W4210497624 creator A5058982648 @default.
- W4210497624 creator A5073177078 @default.
- W4210497624 creator A5076125150 @default.
- W4210497624 creator A5089688879 @default.
- W4210497624 date "2022-01-27" @default.
- W4210497624 modified "2023-10-18" @default.
- W4210497624 title "Organ-Specific Endothelial Cell Differentiation and Impact of Microenvironmental Cues on Endothelial Heterogeneity" @default.
- W4210497624 cites W143420532 @default.
- W4210497624 cites W1489537708 @default.
- W4210497624 cites W1506625266 @default.
- W4210497624 cites W1600560134 @default.
- W4210497624 cites W1836567906 @default.
- W4210497624 cites W1858914267 @default.
- W4210497624 cites W1967396537 @default.
- W4210497624 cites W1970570245 @default.
- W4210497624 cites W1971460289 @default.
- W4210497624 cites W1971677443 @default.
- W4210497624 cites W1972130450 @default.
- W4210497624 cites W1973651527 @default.
- W4210497624 cites W1980401378 @default.
- W4210497624 cites W1981336107 @default.
- W4210497624 cites W1984564880 @default.
- W4210497624 cites W1984808967 @default.
- W4210497624 cites W1986559037 @default.
- W4210497624 cites W1988596206 @default.
- W4210497624 cites W1989422146 @default.
- W4210497624 cites W1996924444 @default.
- W4210497624 cites W2003444365 @default.
- W4210497624 cites W2004365491 @default.
- W4210497624 cites W2007827699 @default.
- W4210497624 cites W2009239190 @default.
- W4210497624 cites W2011140852 @default.
- W4210497624 cites W2013517841 @default.
- W4210497624 cites W2014077602 @default.
- W4210497624 cites W2024574917 @default.
- W4210497624 cites W2025706879 @default.
- W4210497624 cites W2027304461 @default.
- W4210497624 cites W2027852965 @default.
- W4210497624 cites W2030196103 @default.
- W4210497624 cites W2031530438 @default.
- W4210497624 cites W2032112615 @default.
- W4210497624 cites W2032262970 @default.
- W4210497624 cites W2037817950 @default.
- W4210497624 cites W2045247659 @default.
- W4210497624 cites W2046516822 @default.
- W4210497624 cites W2047190365 @default.
- W4210497624 cites W2052992556 @default.
- W4210497624 cites W2055458084 @default.
- W4210497624 cites W2055568757 @default.
- W4210497624 cites W2056565116 @default.
- W4210497624 cites W2060616995 @default.
- W4210497624 cites W2060734951 @default.
- W4210497624 cites W2065657273 @default.
- W4210497624 cites W2075623608 @default.
- W4210497624 cites W2078763854 @default.
- W4210497624 cites W2081135553 @default.
- W4210497624 cites W2081215204 @default.
- W4210497624 cites W2082664445 @default.
- W4210497624 cites W2084420667 @default.
- W4210497624 cites W2085146964 @default.
- W4210497624 cites W2086408506 @default.
- W4210497624 cites W2091574626 @default.
- W4210497624 cites W2091805482 @default.
- W4210497624 cites W2093498435 @default.
- W4210497624 cites W2096164500 @default.
- W4210497624 cites W2096440511 @default.
- W4210497624 cites W2099330106 @default.
- W4210497624 cites W2107141327 @default.
- W4210497624 cites W2113547540 @default.
- W4210497624 cites W2114553353 @default.
- W4210497624 cites W2115716038 @default.
- W4210497624 cites W2119104142 @default.
- W4210497624 cites W2125332169 @default.
- W4210497624 cites W2126875247 @default.
- W4210497624 cites W2127588196 @default.
- W4210497624 cites W2127715753 @default.
- W4210497624 cites W2130962254 @default.
- W4210497624 cites W2131026852 @default.
- W4210497624 cites W2134208433 @default.
- W4210497624 cites W2134232468 @default.
- W4210497624 cites W2135613921 @default.
- W4210497624 cites W2136436931 @default.
- W4210497624 cites W2139615023 @default.
- W4210497624 cites W2142741689 @default.
- W4210497624 cites W2145614469 @default.
- W4210497624 cites W2150911563 @default.
- W4210497624 cites W2152877944 @default.
- W4210497624 cites W2155443465 @default.
- W4210497624 cites W2159246440 @default.
- W4210497624 cites W2159373818 @default.
- W4210497624 cites W2162238950 @default.
- W4210497624 cites W2163526088 @default.
- W4210497624 cites W2164779038 @default.
- W4210497624 cites W2168164971 @default.
- W4210497624 cites W2168498053 @default.
- W4210497624 cites W2169835977 @default.