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- W4210500352 startingPage "58" @default.
- W4210500352 abstract "There are many types and anatomic levels of biliary disease that affect humans. Mechanical bile-duct obstruction usually results from gallstones, stricture or tumour. The morphologic sequelae within the liver itself include cholestasis in centrilobular regions accompanied by a typical set of three lesions: portal tract oedema, proliferation of bile ductular structures and scattered neutrophils. The smaller intrahepatic bile ducts may show segmental specific injury with destruction of bile-duct epithelium and granuloma formation in the condition called primary biliary cholangitis (PBC). The nomenclature for PBC changed in 2015 from ‘primary biliary cirrhosis’ to ‘primary biliary cholangitis’ in order to reflect the absence of cirrhosis from many patient’s clinical courses and to remove the stigma of a disease with ‘cirrhosis’ in the title. Other immune-mediated bile-duct disorders that are discussed include primary sclerosing cholangitis, autoimmune sclerosing cholangitis (a disorder of children) and immunoglobulin G4 (IgG4)-associated cholangitis (part of the spectrum of IgG4-related disorders)." @default.
- W4210500352 created "2022-02-08" @default.
- W4210500352 creator A5069869000 @default.
- W4210500352 date "2021-01-01" @default.
- W4210500352 modified "2023-09-25" @default.
- W4210500352 title "Biliary Disease" @default.
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