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- W4210505278 abstract "The gradient or hierarchical porosity in various natural tissues is a crucial factor for cell migration and mechanical stabilization. In the present study, poly (ε-caprolactone)/zinc oxide (PCL/ZnO) nanocomposite scaffolds containing 0, 5, 10, and 15 wt.% of ZnO nanoparticles were synthesized using salt leaching and solvent casting method to achieve a porous functionally graded structure. X-ray diffractometer (XRD), Fourier transforms infrared spectrometer (FTIR), and scanning electron microscopy (SEM) were respectively used to investigate the phase structure, functional groups, and morphology of the synthesized scaffolds. Additionally, their mechanical properties, biodegradation behavior, cytotoxicity, and cell attachment were assayed via compressive test, immersing in phosphate buffer solution (PBS) for up to 28 days, MTT assay, and SEM, respectively. The obtained results showed that all prepared scaffolds reached a three-layered porous functionally graded structure. While, PCL/ZnO scaffold with 5 wt.% ZnO nanoparticles had the most integrated structure and the highest compressive strength, measured 145.66 ± 7.28 MPa. Furthermore, the most weight loss as a biodegradation parameter was obtained less than 2%. In addition, all prepared samples exhibited excellent cell adhesion without cytotoxicity. • Synthesis of three-layer PCL/nano-ZnO composite scaffolds with different amounts of ZnO nanoparticles. • Synthesis of porous functionally graded scaffolds of PCl/nano-ZnO composite. • Optimize the morphology, mechanical properties and biocompatibility behavior of prepared nanocomposite scaffolds." @default.
- W4210505278 created "2022-02-08" @default.
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- W4210505278 date "2022-03-01" @default.
- W4210505278 modified "2023-09-28" @default.
- W4210505278 title "Porous functionally graded scaffolds of poly (ε-caprolactone)/ZnO nanocomposite for skin tissue engineering: Morphological, mechanical and biological evaluation" @default.
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- W4210505278 doi "https://doi.org/10.1016/j.matchemphys.2022.125786" @default.
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