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- W4210519028 abstract "Bioprinting has seen significant progress in recent years for the fabrication of bionic tissues with high complexity. However, it remains challenging to develop cell-laden bioinks exhibiting superior physiochemical properties and bio-functionality. In this study, a multifunctional nanocomposite bioink is developed based on amine-functionalized copper (Cu)-doped mesoporous bioactive glass nanoparticles (ACuMBGNs) and a hydrogel formulation relying on dynamic covalent chemistry composed of alginate dialdehyde (oxidized alginate) and gelatin, with favorable rheological properties, improved shape fidelity, and structural stability for extrusion-based bioprinting. The reversible dynamic microenvironment in combination with the impact of cell-adhesive ligands introduced by aminated particles enables the rapid spreading (within 3 days) and high survival (>90%) of embedded human osteosarcoma cells and immortalized mouse bone marrow-derived stroma cells. Osteogenic differentiation of primary mouse bone marrow stromal stem cells (BMSCs) and angiogenesis are promoted in the bioprinted alginate dialdehyde-gelatin (ADA-GEL or AG)-ACuMBGN scaffolds without additional growth factors in vitro, which is likely due to ion stimulation from the incorporated nanoparticles and possibly due to cell mechanosensing in the dynamic matrix. In conclusion, it is envisioned that these nanocomposite bioinks can serve as promising platforms for bioprinting complex 3D matrix environments providing superior physiochemical and biological performance for bone tissue engineering." @default.
- W4210519028 created "2022-02-08" @default.
- W4210519028 creator A5001320729 @default.
- W4210519028 creator A5008081990 @default.
- W4210519028 creator A5023027296 @default.
- W4210519028 creator A5028869783 @default.
- W4210519028 creator A5030505493 @default.
- W4210519028 creator A5043592882 @default.
- W4210519028 creator A5050584625 @default.
- W4210519028 creator A5055879264 @default.
- W4210519028 creator A5074923633 @default.
- W4210519028 creator A5091556931 @default.
- W4210519028 date "2022-02-01" @default.
- W4210519028 modified "2023-10-05" @default.
- W4210519028 title "3D Bioprinting of Multifunctional Dynamic Nanocomposite Bioinks Incorporating Cu‐Doped Mesoporous Bioactive Glass Nanoparticles for Bone Tissue Engineering" @default.
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