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- W4210522391 endingPage "112407" @default.
- W4210522391 startingPage "112407" @default.
- W4210522391 abstract "The successful application of nanomedicine against glioma is basically hooked on to the fabrication of specific and efficient glioma targeted multifunctional theranostics. Herein, through an easy synthetic methodology, we fabricated a type of novel multifunctional theranostic nanoplatform comprising of anisotropic gold nanoroses (AuNs) co-loaded with doxorubicin (DOX) and the near-infrared (NIR) active/responsive dye, indocyanine green (ICG). The tailored nanotheranostics upon being exposed to NIR laser helped in achieving combinatorial chemo-phototherapy along with optical cell imaging. BBB/glioma-targeting ability was realized by amalgamating the AuNs with a naive peptide drug with BBB-glioma targeting and anti-glioma twin functionality. Efficacy studies carried out in C6 cells and spheroids demonstrated heightened synergistic glioma chemo-PDT-PTT effect (~85% ablation in C6 cells and ~88% in C6 spheroids) by the AuNDIPs as compared to the individual therapeutic entities. Here, the AuNs derived nanophototheranostics with in force targeting and on-demand drug release nature will further aid in abolishing chemotherapy associated adverse events by adopting a combinatorial approach for synergistic glioma eradication." @default.
- W4210522391 created "2022-02-08" @default.
- W4210522391 creator A5014002525 @default.
- W4210522391 creator A5059534716 @default.
- W4210522391 creator A5072450034 @default.
- W4210522391 date "2022-03-01" @default.
- W4210522391 modified "2023-10-18" @default.
- W4210522391 title "Near infrared triggered chemo-PTT-PDT effect mediated by glioma directed twin functional-chimeric peptide-decorated gold nanoroses" @default.
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- W4210522391 doi "https://doi.org/10.1016/j.jphotobiol.2022.112407" @default.
- W4210522391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35189576" @default.
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