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• W4210537259 startingPage "101" @default.
• W4210537259 abstract "Kaposi sarcoma (KS)-associated herpesvirus (KSHV/HHV-8) was first sequenced from the body cavity (BC) lymphoma cell line, BC-1, in 1996. Few other KSHV genomes have been reported. Our knowledge of sequence variation for this virus remains spotty. This study reports additional genomes from historical US patient samples and from African KS biopsies. It describes an assay that spans regions of the virus that cannot be covered by short read sequencing. These include the terminal repeats, the LANA repeats, and the origins of replication. A phylogenetic analysis, based on 107 genomes, identified three distinct clades; one containing isolates from USA/Europe/Japan collected in the 1990s and two of Sub-Saharan Africa isolates collected since 2010. This analysis indicates that the KSHV strains circulating today differ from the isolates collected at the height of the AIDS epidemic. This analysis helps experimental designs and potential vaccine studies." @default.
• W4210537259 created "2022-02-08" @default.
• W4210537259 creator A5020187882 @default.
• W4210537259 creator A5020774007 @default.
• W4210537259 creator A5021778804 @default.
• W4210537259 creator A5027041023 @default.
• W4210537259 creator A5027432348 @default.
• W4210537259 creator A5041987464 @default.
• W4210537259 creator A5050067581 @default.
• W4210537259 date "2022-03-01" @default.
• W4210537259 modified "2023-10-14" @default.
• W4210537259 title "Whole-genome sequencing of Kaposi sarcoma-associated herpesvirus (KSHV/HHV8) reveals evidence for two African lineages" @default.
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