Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210539440> ?p ?o ?g. }
- W4210539440 endingPage "626" @default.
- W4210539440 startingPage "626" @default.
- W4210539440 abstract "Malignant lymphomas represent the most common type of hematologic malignancies. The first clinically approved TDD modalities in lymphoma patients were anti-CD20 radioimmunoconjugates (RIT) 131I-tositumomab and 90Y-ibritumomab-tiuxetan. The later clinical success of the first approved antibody-drug conjugate (ADC) for the treatment of lymphomas, anti-CD30 brentuximab vedotin, paved the path for the preclinical development and clinical testing of several other ADCs, including polatuzumab vedotin and loncastuximab tesirine. Other modalities of TDD are based on new formulations of old cytostatic agents and their passive trapping in the lymphoma tissue by means of the enhanced permeability and retention (EPR) effect. Currently, the diagnostic and restaging procedures in aggressive lymphomas are based on nuclear imaging, namely PET. A theranostic approach that combines diagnostic or restaging lymphoma imaging with targeted treatment represents an appealing innovative strategy in personalized medicine. The future of theranostics will require not only the capability to provide suitable disease-specific molecular probes but also expertise on big data processing and evaluation. Here, we review the concept of targeted drug delivery in malignant lymphomas from RIT and ADC to a wide array of passively and actively targeted nano-sized investigational agents. We also discuss the future of molecular imaging with special focus on monoclonal antibody-based and monoclonal antibody-derived theranostic strategies." @default.
- W4210539440 created "2022-02-08" @default.
- W4210539440 creator A5000598321 @default.
- W4210539440 creator A5011851320 @default.
- W4210539440 creator A5044531428 @default.
- W4210539440 creator A5066624795 @default.
- W4210539440 creator A5078508839 @default.
- W4210539440 creator A5085470006 @default.
- W4210539440 date "2022-01-26" @default.
- W4210539440 modified "2023-10-09" @default.
- W4210539440 title "Targeted Drug Delivery and Theranostic Strategies in Malignant Lymphomas" @default.
- W4210539440 cites W1821781403 @default.
- W4210539440 cites W1871308790 @default.
- W4210539440 cites W1987843843 @default.
- W4210539440 cites W1987964666 @default.
- W4210539440 cites W1989230986 @default.
- W4210539440 cites W1992994818 @default.
- W4210539440 cites W2002089022 @default.
- W4210539440 cites W2002516695 @default.
- W4210539440 cites W2008729212 @default.
- W4210539440 cites W2008815830 @default.
- W4210539440 cites W2012144021 @default.
- W4210539440 cites W2014654561 @default.
- W4210539440 cites W2017225733 @default.
- W4210539440 cites W2043499815 @default.
- W4210539440 cites W2046459748 @default.
- W4210539440 cites W2051066572 @default.
- W4210539440 cites W2051925512 @default.
- W4210539440 cites W2059017383 @default.
- W4210539440 cites W206701898 @default.
- W4210539440 cites W2077388217 @default.
- W4210539440 cites W2084587462 @default.
- W4210539440 cites W2087516193 @default.
- W4210539440 cites W2095472682 @default.
- W4210539440 cites W2104940816 @default.
- W4210539440 cites W2106071154 @default.
- W4210539440 cites W2112607550 @default.
- W4210539440 cites W2113426218 @default.
- W4210539440 cites W2122584026 @default.
- W4210539440 cites W2125616358 @default.
- W4210539440 cites W2137558090 @default.
- W4210539440 cites W2142844050 @default.
- W4210539440 cites W2146205672 @default.
- W4210539440 cites W2147328441 @default.
- W4210539440 cites W2148127139 @default.
- W4210539440 cites W2154066874 @default.
- W4210539440 cites W2155256323 @default.
- W4210539440 cites W2181837339 @default.
- W4210539440 cites W2187976253 @default.
- W4210539440 cites W2190884983 @default.
- W4210539440 cites W2279127916 @default.
- W4210539440 cites W2287519522 @default.
- W4210539440 cites W2310716991 @default.
- W4210539440 cites W2317610963 @default.
- W4210539440 cites W2324528766 @default.
- W4210539440 cites W2331664759 @default.
- W4210539440 cites W2388009875 @default.
- W4210539440 cites W2397876963 @default.
- W4210539440 cites W2419639370 @default.
- W4210539440 cites W2547412310 @default.
- W4210539440 cites W2582125928 @default.
- W4210539440 cites W2599276599 @default.
- W4210539440 cites W2605472137 @default.
- W4210539440 cites W2609973112 @default.
- W4210539440 cites W2623658063 @default.
- W4210539440 cites W2636487951 @default.
- W4210539440 cites W2704364151 @default.
- W4210539440 cites W2725925241 @default.
- W4210539440 cites W2744261860 @default.
- W4210539440 cites W2749221865 @default.
- W4210539440 cites W2760907988 @default.
- W4210539440 cites W2761878534 @default.
- W4210539440 cites W2769582114 @default.
- W4210539440 cites W2773804840 @default.
- W4210539440 cites W2775803967 @default.
- W4210539440 cites W2786885861 @default.
- W4210539440 cites W2791128353 @default.
- W4210539440 cites W2797455782 @default.
- W4210539440 cites W2798249412 @default.
- W4210539440 cites W2801159784 @default.
- W4210539440 cites W2804919400 @default.
- W4210539440 cites W2883399820 @default.
- W4210539440 cites W2884362356 @default.
- W4210539440 cites W2888407625 @default.
- W4210539440 cites W2889054280 @default.
- W4210539440 cites W2889138317 @default.
- W4210539440 cites W2894357803 @default.
- W4210539440 cites W2898183660 @default.
- W4210539440 cites W2902719404 @default.
- W4210539440 cites W2903062212 @default.
- W4210539440 cites W2903308035 @default.
- W4210539440 cites W2914342702 @default.
- W4210539440 cites W2938122619 @default.
- W4210539440 cites W2946024019 @default.
- W4210539440 cites W2958576566 @default.
- W4210539440 cites W2971474936 @default.
- W4210539440 cites W2981241448 @default.
- W4210539440 cites W2984927918 @default.