FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210549104> ?p ?o ?g. }

• W4210549104 endingPage "348" @default.
• W4210549104 startingPage "348" @default.
• W4210549104 abstract "Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma in adults and reveals distinct genetic and metabolic signatures. NF-κB transcription factor family is involved in diverse biological processes enabling tumor development and resistance to anticancer-therapy through activation of its two main pathways, the canonical and the alternative NF-κB pathways, the main actor of the latter being the RelB NF-kB subunit. RelB DNA binding activity is frequently activated in DLBCL patients and cell lines. RelB activation defines a new DLBCL subgroup with dismal outcome upon immunochemotherapy, and RelB confers DLBCL cell resistance to DNA damage. However, whether RelB can impact on DLBCL cell metabolism and survival upon metabolic stress is unknown. Here, we reveal that RelB controls DLBCL oxidative energetic metabolism. Accordingly, RelB inhibition reduce DLBCL mitochondrial ATP production, and sensitizes DLBCL cells to apoptosis induced by Metformin and L-asparaginase (®Kidrolase), two FDA approved antimetabolic drugs targeting mitochondrial metabolism. RelB also confers DLBCL cell resistance to glutamine deprivation, an essential amino acid that feeds the TCA cycle. Taken together, our findings uncover a new role for RelB in the regulation of DLBCL cell metabolism and DLBCL cell survival upon metabolic stress." @default.
• W4210549104 created "2022-02-08" @default.
• W4210549104 creator A5022422604 @default.
• W4210549104 creator A5030963183 @default.
• W4210549104 creator A5033073385 @default.
• W4210549104 creator A5090308329 @default.
• W4210549104 date "2022-02-01" @default.
• W4210549104 modified "2023-10-16" @default.
• W4210549104 title "The Alternative RelB NF-kB Subunit Exerts a Critical Survival Function upon Metabolic Stress in Diffuse Large B-Cell Lymphoma-Derived Cells" @default.
• W4210549104 cites W1531083195 @default.
• W4210549104 cites W1533021978 @default.
• W4210549104 cites W1976174817 @default.
• W4210549104 cites W1979816280 @default.
• W4210549104 cites W1980966444 @default.
• W4210549104 cites W2014058353 @default.
• W4210549104 cites W2018071905 @default.
• W4210549104 cites W2020789296 @default.
• W4210549104 cites W2029000257 @default.
• W4210549104 cites W2031855605 @default.
• W4210549104 cites W2035135710 @default.
• W4210549104 cites W2037796411 @default.
• W4210549104 cites W2051012784 @default.
• W4210549104 cites W2051923563 @default.
• W4210549104 cites W2055677253 @default.
• W4210549104 cites W2058015212 @default.
• W4210549104 cites W2064196866 @default.
• W4210549104 cites W2068453332 @default.
• W4210549104 cites W2070923004 @default.
• W4210549104 cites W2072451938 @default.
• W4210549104 cites W2074688366 @default.
• W4210549104 cites W2088698826 @default.
• W4210549104 cites W2097259163 @default.
• W4210549104 cites W2101799172 @default.
• W4210549104 cites W2110467543 @default.
• W4210549104 cites W2116382435 @default.
• W4210549104 cites W2117692326 @default.
• W4210549104 cites W2124343538 @default.
• W4210549104 cites W2136426653 @default.
• W4210549104 cites W2147246240 @default.
• W4210549104 cites W2150382709 @default.
• W4210549104 cites W2174823906 @default.
• W4210549104 cites W2320006945 @default.
• W4210549104 cites W2326263722 @default.
• W4210549104 cites W2395626624 @default.
• W4210549104 cites W2509261975 @default.
• W4210549104 cites W2535779204 @default.
• W4210549104 cites W2577266312 @default.
• W4210549104 cites W2597896859 @default.
• W4210549104 cites W2620769476 @default.
• W4210549104 cites W2750580784 @default.
• W4210549104 cites W2801763724 @default.
• W4210549104 cites W2805139397 @default.
• W4210549104 cites W3016044607 @default.
• W4210549104 cites W3025155304 @default.
• W4210549104 cites W3179581638 @default.
• W4210549104 cites W4210490242 @default.
• W4210549104 doi "https://doi.org/10.3390/biomedicines10020348" @default.
• W4210549104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35203557" @default.
• W4210549104 hasPublicationYear "2022" @default.
• W4210549104 type Work @default.
• W4210549104 citedByCount "5" @default.
• W4210549104 countsByYear W42105491042022 @default.
• W4210549104 countsByYear W42105491042023 @default.
• W4210549104 crossrefType "journal-article" @default.
• W4210549104 hasAuthorship W4210549104A5022422604 @default.
• W4210549104 hasAuthorship W4210549104A5030963183 @default.
• W4210549104 hasAuthorship W4210549104A5033073385 @default.
• W4210549104 hasAuthorship W4210549104A5090308329 @default.
• W4210549104 hasBestOaLocation W42105491041 @default.
• W4210549104 hasConcept C104317684 @default.
• W4210549104 hasConcept C203014093 @default.
• W4210549104 hasConcept C2777453290 @default.
• W4210549104 hasConcept C2778559949 @default.
• W4210549104 hasConcept C2779338263 @default.
• W4210549104 hasConcept C502942594 @default.
• W4210549104 hasConcept C54355233 @default.
• W4210549104 hasConcept C86339819 @default.
• W4210549104 hasConcept C86803240 @default.
• W4210549104 hasConcept C98270193 @default.
• W4210549104 hasConceptScore W4210549104C104317684 @default.
• W4210549104 hasConceptScore W4210549104C203014093 @default.
• W4210549104 hasConceptScore W4210549104C2777453290 @default.
• W4210549104 hasConceptScore W4210549104C2778559949 @default.
• W4210549104 hasConceptScore W4210549104C2779338263 @default.
• W4210549104 hasConceptScore W4210549104C502942594 @default.
• W4210549104 hasConceptScore W4210549104C54355233 @default.
• W4210549104 hasConceptScore W4210549104C86339819 @default.
• W4210549104 hasConceptScore W4210549104C86803240 @default.
• W4210549104 hasConceptScore W4210549104C98270193 @default.
• W4210549104 hasFunder F4320320883 @default.
• W4210549104 hasFunder F4320322361 @default.
• W4210549104 hasFunder F4320323807 @default.
• W4210549104 hasFunder F4320325084 @default.
• W4210549104 hasIssue "2" @default.
• W4210549104 hasLocation W42105491041 @default.
• W4210549104 hasLocation W42105491042 @default.
• W4210549104 hasLocation W42105491043 @default.
• W4210549104 hasOpenAccess W4210549104 @default.

• next