Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210549285> ?p ?o ?g. }
- W4210549285 endingPage "1713" @default.
- W4210549285 startingPage "1713" @default.
- W4210549285 abstract "The oocyte and the surrounding cumulus cells (CCs) are deeply linked by a complex bidirectional cross-talk. In this light, the molecular analysis of the CCs is nowadays considered to be precious in providing information on oocyte quality. It is now clear that miRNAs play a key role in several ovarian functions, such as folliculogenesis, steroidogenesis, and ovulation. Thus, in this study, specific miRNAs, together with their target genes, were selected and investigated in CCs to assess the response of patients with normal (NR) and low (LR) ovarian reserve to two different controlled ovarian stimulation (COS) protocols, based on rFSH and hMG. Moreover, a Fourier transform infrared microspectroscopy (FTIRM) analysis was performed to evaluate DNA conformational changes in CCs and to relate them with the two COS protocols. The results evidenced a modulation of the expression of miRNAs and related target genes involved in CCs' proliferation, in vasculogenesis, angiogenesis, genomic integrity, and oocyte quality, with different effects according to the ovarian reserve of patients. Moreover, the COS protocols determined differences in DNA conformation and the methylation state. In particular, the results clearly showed that treatment with rFSH is the most appropriate in NR patients with normal ovarian reserve, while treatment with hMG appears to be the most suitable in LR patients with low ovarian reserve." @default.
- W4210549285 created "2022-02-08" @default.
- W4210549285 creator A5004880055 @default.
- W4210549285 creator A5007945612 @default.
- W4210549285 creator A5013970240 @default.
- W4210549285 creator A5030132286 @default.
- W4210549285 creator A5035271366 @default.
- W4210549285 creator A5053252305 @default.
- W4210549285 creator A5059140277 @default.
- W4210549285 creator A5067474712 @default.
- W4210549285 creator A5075971623 @default.
- W4210549285 creator A5076547213 @default.
- W4210549285 date "2022-02-02" @default.
- W4210549285 modified "2023-10-14" @default.
- W4210549285 title "Evaluation of Controlled Ovarian Stimulation Protocols in Patients with Normal and Low Ovarian Reserve: Analyses of miRNAs and Selected Target Genes Involved in the Proliferation of Human Cumulus Cells and Oocyte Quality" @default.
- W4210549285 cites W1149146151 @default.
- W4210549285 cites W1561425460 @default.
- W4210549285 cites W1577577364 @default.
- W4210549285 cites W183637139 @default.
- W4210549285 cites W1906463259 @default.
- W4210549285 cites W1964083893 @default.
- W4210549285 cites W1972941961 @default.
- W4210549285 cites W1984591171 @default.
- W4210549285 cites W1985851879 @default.
- W4210549285 cites W1999137852 @default.
- W4210549285 cites W2000842113 @default.
- W4210549285 cites W2007338911 @default.
- W4210549285 cites W2011055829 @default.
- W4210549285 cites W2016206030 @default.
- W4210549285 cites W2020898584 @default.
- W4210549285 cites W2042190518 @default.
- W4210549285 cites W2049798608 @default.
- W4210549285 cites W2068382425 @default.
- W4210549285 cites W2077064497 @default.
- W4210549285 cites W2077243848 @default.
- W4210549285 cites W2078956438 @default.
- W4210549285 cites W2080360745 @default.
- W4210549285 cites W2082646095 @default.
- W4210549285 cites W2093922429 @default.
- W4210549285 cites W2099392253 @default.
- W4210549285 cites W2101821211 @default.
- W4210549285 cites W2103031848 @default.
- W4210549285 cites W2108244474 @default.
- W4210549285 cites W2115798190 @default.
- W4210549285 cites W2117747493 @default.
- W4210549285 cites W2119852674 @default.
- W4210549285 cites W2120509278 @default.
- W4210549285 cites W2122597069 @default.
- W4210549285 cites W2162210168 @default.
- W4210549285 cites W2168420558 @default.
- W4210549285 cites W2176164372 @default.
- W4210549285 cites W2255429993 @default.
- W4210549285 cites W2320413180 @default.
- W4210549285 cites W2520790663 @default.
- W4210549285 cites W2554681483 @default.
- W4210549285 cites W2556485426 @default.
- W4210549285 cites W2629524083 @default.
- W4210549285 cites W2767040563 @default.
- W4210549285 cites W2768632638 @default.
- W4210549285 cites W2806365746 @default.
- W4210549285 cites W2886714356 @default.
- W4210549285 cites W2889990912 @default.
- W4210549285 cites W2907323199 @default.
- W4210549285 cites W2912567453 @default.
- W4210549285 cites W2923768126 @default.
- W4210549285 cites W2975965099 @default.
- W4210549285 cites W2981936341 @default.
- W4210549285 cites W3023643850 @default.
- W4210549285 cites W3035818907 @default.
- W4210549285 cites W3088507343 @default.
- W4210549285 cites W3092702057 @default.
- W4210549285 cites W3109151530 @default.
- W4210549285 cites W3164619306 @default.
- W4210549285 cites W3195222323 @default.
- W4210549285 doi "https://doi.org/10.3390/ijms23031713" @default.
- W4210549285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35163635" @default.
- W4210549285 hasPublicationYear "2022" @default.
- W4210549285 type Work @default.
- W4210549285 citedByCount "0" @default.
- W4210549285 crossrefType "journal-article" @default.
- W4210549285 hasAuthorship W4210549285A5004880055 @default.
- W4210549285 hasAuthorship W4210549285A5007945612 @default.
- W4210549285 hasAuthorship W4210549285A5013970240 @default.
- W4210549285 hasAuthorship W4210549285A5030132286 @default.
- W4210549285 hasAuthorship W4210549285A5035271366 @default.
- W4210549285 hasAuthorship W4210549285A5053252305 @default.
- W4210549285 hasAuthorship W4210549285A5059140277 @default.
- W4210549285 hasAuthorship W4210549285A5067474712 @default.
- W4210549285 hasAuthorship W4210549285A5075971623 @default.
- W4210549285 hasAuthorship W4210549285A5076547213 @default.
- W4210549285 hasBestOaLocation W42105492851 @default.
- W4210549285 hasConcept C104317684 @default.
- W4210549285 hasConcept C134018914 @default.
- W4210549285 hasConcept C145059251 @default.
- W4210549285 hasConcept C16685009 @default.
- W4210549285 hasConcept C196843134 @default.
- W4210549285 hasConcept C24998067 @default.
- W4210549285 hasConcept C2776600139 @default.