Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210549689> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4210549689 abstract "Localising accurate brain regions needs careful evaluation in each experimental species due to their individual variability. However, the function and connectivity of brain areas is commonly studied using a single-subject cranial landmark-based stereotactic atlas in animal neuroscience. Here, we address this issue in a small primate, the common marmoset, which is increasingly widely used in systems neuroscience. We developed a non-invasive multi-modal neuroimaging-based targeting pipeline, which accounts for intersubject anatomical variability in cranial and cortical landmarks in marmosets. This methodology allowed creation of multi-modal templates (MarmosetRIKEN20) including head CT and brain MR images, embedded in coordinate systems of anterior and posterior commissures (AC-PC) and CIFTI grayordinates. We found that the horizontal plane of the stereotactic coordinate was significantly rotated in pitch relative to the AC-PC coordinate system (10 degrees, frontal downwards), and had a significant bias and uncertainty due to positioning procedures. We also found that many common cranial and brain landmarks (e.g., bregma, intraparietal sulcus) vary in location across subjects and are substantial relative to average marmoset cortical area dimensions. Combining the neuroimaging-based targeting pipeline with robot-guided surgery enabled proof-of-concept targeting of deep brain structures with an accuracy of 0.2 mm. Altogether, our findings demonstrate substantial intersubject variability in marmoset brain and cranial landmarks, implying that subject-specific neuroimaging-based localization is needed for precision targeting in marmosets. The population-based templates and atlases in grayordinates, created for the first time in marmoset monkeys, should help bridging between macroscale and microscale analyses." @default.
- W4210549689 created "2022-02-08" @default.
- W4210549689 creator A5001845488 @default.
- W4210549689 creator A5002626271 @default.
- W4210549689 creator A5006729002 @default.
- W4210549689 creator A5007588355 @default.
- W4210549689 creator A5008342258 @default.
- W4210549689 creator A5009553909 @default.
- W4210549689 creator A5010575447 @default.
- W4210549689 creator A5018123022 @default.
- W4210549689 creator A5020951387 @default.
- W4210549689 creator A5047238141 @default.
- W4210549689 creator A5049622499 @default.
- W4210549689 creator A5057170842 @default.
- W4210549689 creator A5070944196 @default.
- W4210549689 creator A5072742526 @default.
- W4210549689 creator A5075048849 @default.
- W4210549689 creator A5085046514 @default.
- W4210549689 creator A5086200068 @default.
- W4210549689 date "2022-02-02" @default.
- W4210549689 modified "2023-09-30" @default.
- W4210549689 title "Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain" @default.
- W4210549689 doi "https://doi.org/10.1101/2022.01.31.478477" @default.
- W4210549689 hasPublicationYear "2022" @default.
- W4210549689 type Work @default.
- W4210549689 citedByCount "0" @default.
- W4210549689 crossrefType "posted-content" @default.
- W4210549689 hasAuthorship W4210549689A5001845488 @default.
- W4210549689 hasAuthorship W4210549689A5002626271 @default.
- W4210549689 hasAuthorship W4210549689A5006729002 @default.
- W4210549689 hasAuthorship W4210549689A5007588355 @default.
- W4210549689 hasAuthorship W4210549689A5008342258 @default.
- W4210549689 hasAuthorship W4210549689A5009553909 @default.
- W4210549689 hasAuthorship W4210549689A5010575447 @default.
- W4210549689 hasAuthorship W4210549689A5018123022 @default.
- W4210549689 hasAuthorship W4210549689A5020951387 @default.
- W4210549689 hasAuthorship W4210549689A5047238141 @default.
- W4210549689 hasAuthorship W4210549689A5049622499 @default.
- W4210549689 hasAuthorship W4210549689A5057170842 @default.
- W4210549689 hasAuthorship W4210549689A5070944196 @default.
- W4210549689 hasAuthorship W4210549689A5072742526 @default.
- W4210549689 hasAuthorship W4210549689A5075048849 @default.
- W4210549689 hasAuthorship W4210549689A5085046514 @default.
- W4210549689 hasAuthorship W4210549689A5086200068 @default.
- W4210549689 hasBestOaLocation W42105496891 @default.
- W4210549689 hasConcept C151730666 @default.
- W4210549689 hasConcept C154945302 @default.
- W4210549689 hasConcept C15744967 @default.
- W4210549689 hasConcept C169760540 @default.
- W4210549689 hasConcept C2776453536 @default.
- W4210549689 hasConcept C2779504336 @default.
- W4210549689 hasConcept C31972630 @default.
- W4210549689 hasConcept C41008148 @default.
- W4210549689 hasConcept C58693492 @default.
- W4210549689 hasConcept C86803240 @default.
- W4210549689 hasConceptScore W4210549689C151730666 @default.
- W4210549689 hasConceptScore W4210549689C154945302 @default.
- W4210549689 hasConceptScore W4210549689C15744967 @default.
- W4210549689 hasConceptScore W4210549689C169760540 @default.
- W4210549689 hasConceptScore W4210549689C2776453536 @default.
- W4210549689 hasConceptScore W4210549689C2779504336 @default.
- W4210549689 hasConceptScore W4210549689C31972630 @default.
- W4210549689 hasConceptScore W4210549689C41008148 @default.
- W4210549689 hasConceptScore W4210549689C58693492 @default.
- W4210549689 hasConceptScore W4210549689C86803240 @default.
- W4210549689 hasLocation W42105496891 @default.
- W4210549689 hasLocation W42105496892 @default.
- W4210549689 hasOpenAccess W4210549689 @default.
- W4210549689 hasPrimaryLocation W42105496891 @default.
- W4210549689 hasRelatedWork W2076328179 @default.
- W4210549689 hasRelatedWork W2123371569 @default.
- W4210549689 hasRelatedWork W2468113650 @default.
- W4210549689 hasRelatedWork W2617682152 @default.
- W4210549689 hasRelatedWork W2899084033 @default.
- W4210549689 hasRelatedWork W2943636876 @default.
- W4210549689 hasRelatedWork W2945021047 @default.
- W4210549689 hasRelatedWork W2953420983 @default.
- W4210549689 hasRelatedWork W2971871241 @default.
- W4210549689 hasRelatedWork W4319018116 @default.
- W4210549689 isParatext "false" @default.
- W4210549689 isRetracted "false" @default.
- W4210549689 workType "article" @default.