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- W4210551878 abstract "Mature cystic teratomas are benign ovarian germ cell tumours, comprised of tissues from at least two of three germ layers, and constitute 10–20% of all ovarian neoplasms. A variety of malignant tumours may arise from within mature cystic teratomas, though this occurs relatively infrequently, in 0.2–1.8% of cases. Of these, malignant melanomas occur very rarely. We present a case of a 44-year-old woman who presented acutely with abdominal pain, and was found to have malignant melanoma arising from within a 6 cm ovarian mature cystic teratoma. A full skin and vulval examination did not identify any other potential primary melanocytic lesions. Disseminated peritoneal disease was identified on subsequent staging imaging, and the patient was started on treatment with pembrolizumab. A review of the existing literature showed approximately 45 case reports to date, with the first in 1901. Treatment approaches have been varied, with surgery as a mainstay, either alone or with adjuvant chemotherapy or immunotherapy. Prognosis is generally accepted to be poor. Characterisation of molecular features has been limited. Given the rarity of this entity, there is no consensus for standard therapy, and evidence to date is largely anecdotal." @default.
- W4210551878 created "2022-02-08" @default.
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- W4210551878 date "2022-03-01" @default.
- W4210551878 modified "2023-09-26" @default.
- W4210551878 title "Malignant melanoma arising within a dermoid cyst: A case report" @default.
- W4210551878 doi "https://doi.org/10.1016/j.pathol.2021.12.150" @default.
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