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- W4210567612 abstract "Abstract Clinical trials represent a fulcrum for oncology drug discovery and development to bring safe and effective medicines to patients in a timely manner. Clinical trials have shifted from traditional studies evaluating cytotoxic chemotherapy in largely histology-based populations to become adaptively designed and biomarker-driven evaluations of molecularly targeted agents and immune therapies in selected patient subsets. This review will discuss the scientific, methodological, practical, and patient-focused considerations to transform clinical trials. A call to action is proposed to establish the framework for next-generation clinical trials that strikes an optimal balance of operational efficiency, scientific impact, and value to patients. Significance: The future of cancer clinical trials requires a framework that can efficiently transform scientific discoveries to clinical utility through applications of innovative technologies and dynamic design methodologies. Next-generation clinical trials will offer individualized strategies which ultimately contribute to globalized knowledge and collective learning, through the joint efforts of all key stakeholders including investigators and patients." @default.
- W4210567612 created "2022-02-08" @default.
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- W4210567612 date "2021-04-01" @default.
- W4210567612 modified "2023-10-10" @default.
- W4210567612 title "The Future of Clinical Trial Design in Oncology" @default.
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- W4210567612 doi "https://doi.org/10.1158/2159-8290.cd-20-1301" @default.
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