FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210573534> ?p ?o ?g. }

• W4210573534 endingPage "607" @default.
• W4210573534 startingPage "597" @default.
• W4210573534 abstract "Objective To assess the effect of statin use on the risk of cardiovascular disease (CVD), all-cause mortality, and type 2 diabetes mellitus (DM) in patients with rheumatoid arthritis (RA). Methods We identified a cohort of patients with RA between 1989 and 2018, within the UK Clinical Practice Research Datalink. We employed a prevalent new-user cohort design by which patients initiating statins were each matched to 2 concurrent nonusers by the time-conditional propensity score (TCPS). Patients were followed until the occurrence of the composite end point of myocardial infarction, stroke, hospitalized heart failure or CVD mortality, all-cause mortality, and incident type 2 DM. The Cox proportional hazards model was used to estimate the hazard ratio (HR) of each outcome associated with as-treated statin use, with adjustment for TCPS deciles and imbalanced covariables. Results Among 1,768 statin initiators and 3,528 nonusers, 63 versus 340 CVD (3.0 per 100 person-years versus 2.7 per 100 person-years) and 62 versus 525 deaths (2.8 per 100 person-years versus 4.1 per 100 person-years) occurred. Incident type 2 DM was noted in 128 of 3,608 statin initiators (3.0 per 100 person-years) and 518 of 7,208 nonusers (2.0 per 100 person-years). Statin initiation was associated with 32% (HR 0.68 [95% confidence interval (95% CI) 0.51–0.90]) reduction in CVD, 54% (HR 0.46 [95% CI 0.35–0.60]) reduction in all-cause mortality, and 33% increase in type 2 DM (HR 1.33 [95% CI 1.09–1.63]). The number needed to treat/number needed to harm to prevent a CVD or all-cause mortality or to cause type 2 DM in 1 year was 102, 42, and 127, respectively. Conclusion Statins are associated with important reductions in CVD and mortality that outweigh the modest increase in type 2 DM risk in RA patients." @default.
• W4210573534 created "2022-02-08" @default.
• W4210573534 creator A5005535362 @default.
• W4210573534 creator A5008217187 @default.
• W4210573534 creator A5017432882 @default.
• W4210573534 creator A5041110185 @default.
• W4210573534 creator A5044067217 @default.
• W4210573534 date "2022-11-17" @default.
• W4210573534 modified "2023-10-18" @default.
• W4210573534 title "Reduction of Cardiovascular Disease and Mortality Versus Risk of New‐Onset Diabetes Mellitus With Statin Use in Patients With Rheumatoid Arthritis" @default.
• W4210573534 cites W1841637395 @default.
• W4210573534 cites W1966333793 @default.
• W4210573534 cites W1989417654 @default.
• W4210573534 cites W2007205421 @default.
• W4210573534 cites W2007954685 @default.
• W4210573534 cites W2015410646 @default.
• W4210573534 cites W2035292279 @default.
• W4210573534 cites W2046708356 @default.
• W4210573534 cites W2055718631 @default.
• W4210573534 cites W2066739773 @default.
• W4210573534 cites W2082120877 @default.
• W4210573534 cites W2097303364 @default.
• W4210573534 cites W2097510503 @default.
• W4210573534 cites W2103108681 @default.
• W4210573534 cites W2103663530 @default.
• W4210573534 cites W2103946550 @default.
• W4210573534 cites W2115169717 @default.
• W4210573534 cites W2118063651 @default.
• W4210573534 cites W2119852447 @default.
• W4210573534 cites W2120685826 @default.
• W4210573534 cites W2121283103 @default.
• W4210573534 cites W2121535401 @default.
• W4210573534 cites W2126919962 @default.
• W4210573534 cites W2127932395 @default.
• W4210573534 cites W2142686703 @default.
• W4210573534 cites W2144294832 @default.
• W4210573534 cites W2158413014 @default.
• W4210573534 cites W2164089346 @default.
• W4210573534 cites W2164750952 @default.
• W4210573534 cites W2465758073 @default.
• W4210573534 cites W2509390568 @default.
• W4210573534 cites W2514757162 @default.
• W4210573534 cites W2519634482 @default.
• W4210573534 cites W2519686100 @default.
• W4210573534 cites W2528648757 @default.
• W4210573534 cites W2555847134 @default.
• W4210573534 cites W2608320814 @default.
• W4210573534 cites W2767820760 @default.
• W4210573534 cites W2811081211 @default.
• W4210573534 cites W2969531623 @default.
• W4210573534 cites W2998589471 @default.
• W4210573534 cites W3113480125 @default.
• W4210573534 cites W3134841124 @default.
• W4210573534 cites W3140388327 @default.
• W4210573534 doi "https://doi.org/10.1002/acr.24866" @default.
• W4210573534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35119769" @default.
• W4210573534 hasPublicationYear "2022" @default.
• W4210573534 type Work @default.
• W4210573534 citedByCount "6" @default.
• W4210573534 countsByYear W42105735342022 @default.
• W4210573534 countsByYear W42105735342023 @default.
• W4210573534 crossrefType "journal-article" @default.
• W4210573534 hasAuthorship W4210573534A5005535362 @default.
• W4210573534 hasAuthorship W4210573534A5008217187 @default.
• W4210573534 hasAuthorship W4210573534A5017432882 @default.
• W4210573534 hasAuthorship W4210573534A5041110185 @default.
• W4210573534 hasAuthorship W4210573534A5044067217 @default.
• W4210573534 hasConcept C126322002 @default.
• W4210573534 hasConcept C134018914 @default.
• W4210573534 hasConcept C201903717 @default.
• W4210573534 hasConcept C207103383 @default.
• W4210573534 hasConcept C2776839432 @default.
• W4210573534 hasConcept C2777575956 @default.
• W4210573534 hasConcept C44249647 @default.
• W4210573534 hasConcept C500558357 @default.
• W4210573534 hasConcept C50382708 @default.
• W4210573534 hasConcept C555293320 @default.
• W4210573534 hasConcept C71924100 @default.
• W4210573534 hasConcept C72563966 @default.
• W4210573534 hasConceptScore W4210573534C126322002 @default.
• W4210573534 hasConceptScore W4210573534C134018914 @default.
• W4210573534 hasConceptScore W4210573534C201903717 @default.
• W4210573534 hasConceptScore W4210573534C207103383 @default.
• W4210573534 hasConceptScore W4210573534C2776839432 @default.
• W4210573534 hasConceptScore W4210573534C2777575956 @default.
• W4210573534 hasConceptScore W4210573534C44249647 @default.
• W4210573534 hasConceptScore W4210573534C500558357 @default.
• W4210573534 hasConceptScore W4210573534C50382708 @default.
• W4210573534 hasConceptScore W4210573534C555293320 @default.
• W4210573534 hasConceptScore W4210573534C71924100 @default.
• W4210573534 hasConceptScore W4210573534C72563966 @default.
• W4210573534 hasFunder F4320332611 @default.
• W4210573534 hasIssue "3" @default.
• W4210573534 hasLocation W42105735341 @default.
• W4210573534 hasLocation W42105735342 @default.
• W4210573534 hasOpenAccess W4210573534 @default.
• W4210573534 hasPrimaryLocation W42105735341 @default.
• W4210573534 hasRelatedWork W1516595110 @default.

• next