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• W4210576538 abstract "This study determined the frequency and the clinicopathologic and genetic features of colorectal carcinomas driven by oncogenic fusions of the anaplastic lymphoma kinase gene (ALK). Of the 8150 screened tumors, 12 (0.15%) were immunohistochemically ALK-positive with D5F3 antibody. These cancers harbored CAD-ALK (n=1), DIAPH2-ALK (n=2), EML4-ALK (n=2), LOC101929227-ALK (n=1), SLMAP-ALK (n=1), SPTBN1-ALK (n=4), and STRN-ALK (n=1) fusions, as detected by an RNA-based next-generation sequencing assay. ALK fusion carcinomas were diagnosed mostly in older patients with a 9:3 female predominance (median age: 72 y). All tumors, except a rectal one, occurred in the right colon. Most tumors were stage T3 (n=7) or T4 (n=3). Local lymph node and distant metastases were seen at presentation in 9 and 2 patients. These tumors showed moderate (n=6) or poor (n=3) glandular differentiation, solid medullary growth pattern (n=2), and pure mucinous morphology (n=1). DNA mismatch repair-deficient phenotype was identified in 10 cases. Tumor-infiltrating lymphocytes were prominent in 9 carcinomas. In 4 carcinomas, tumor cells showed strong, focal (n=3), or diffuse programmed death-ligand 1 immunoreactivity. CDX2 expression and loss of CK20 and MUC2 expression were frequent. CK7 was expressed in 5 tumors. Four patients died of disease within 3 years, and 7 were alive with follow-up ranging from 1 to 8 years. No mutations in BRAF, RAS, and in genes encoding components of PI3K-AKT/MTOR pathway were identified. However, 1 tumor had a loss-of-function PTEN mutation. Aberration of p53 signaling, TP53 mutations, and/or nuclear accumulation of p53 protein was seen in 9 cases. ALK fusion colorectal carcinomas are a distinct and rare subtype of colorectal cancers displaying some features of mismatch repair-deficient tumors." @default.
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• W4210576538 date "2020-07-03" @default.
• W4210576538 modified "2023-10-17" @default.
• W4210576538 title "Colorectal Adenocarcinomas Harboring ALK Fusion Genes" @default.
• W4210576538 cites W1657664540 @default.
• W4210576538 cites W1832172388 @default.
• W4210576538 cites W1957204337 @default.
• W4210576538 cites W1986226514 @default.
• W4210576538 cites W1996321846 @default.
• W4210576538 cites W1999029326 @default.
• W4210576538 cites W2004655945 @default.
• W4210576538 cites W2018336040 @default.
• W4210576538 cites W2026002143 @default.
• W4210576538 cites W2038586807 @default.
• W4210576538 cites W2039840629 @default.
• W4210576538 cites W2053343049 @default.
• W4210576538 cites W2055402151 @default.
• W4210576538 cites W2055732173 @default.
• W4210576538 cites W2059970788 @default.
• W4210576538 cites W2067472931 @default.
• W4210576538 cites W2074768718 @default.
• W4210576538 cites W2086718822 @default.
• W4210576538 cites W2090789702 @default.
• W4210576538 cites W2093524469 @default.
• W4210576538 cites W2139349962 @default.
• W4210576538 cites W2145247101 @default.
• W4210576538 cites W2153782264 @default.
• W4210576538 cites W2167060638 @default.
• W4210576538 cites W2179698428 @default.
• W4210576538 cites W2197766619 @default.
• W4210576538 cites W2207801144 @default.
• W4210576538 cites W2211426736 @default.
• W4210576538 cites W2278884409 @default.
• W4210576538 cites W2292375548 @default.
• W4210576538 cites W2304533799 @default.
• W4210576538 cites W2316823558 @default.
• W4210576538 cites W2464971843 @default.
• W4210576538 cites W2476165008 @default.
• W4210576538 cites W2529399201 @default.
• W4210576538 cites W2548020690 @default.
• W4210576538 cites W2564332693 @default.
• W4210576538 cites W2565081035 @default.
• W4210576538 cites W2614323479 @default.
• W4210576538 cites W2616119389 @default.
• W4210576538 cites W2620839015 @default.
• W4210576538 cites W2770347143 @default.
• W4210576538 cites W2786855717 @default.
• W4210576538 cites W2805608686 @default.
• W4210576538 cites W2809946219 @default.
• W4210576538 cites W2887067858 @default.
• W4210576538 cites W2899366033 @default.
• W4210576538 cites W2908229188 @default.
• W4210576538 cites W2914746101 @default.
• W4210576538 cites W2914981515 @default.
• W4210576538 cites W2948961777 @default.
• W4210576538 cites W2966521866 @default.
• W4210576538 cites W2975493108 @default.
• W4210576538 cites W4254323320 @default.

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