Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210579596> ?p ?o ?g. }
- W4210579596 abstract "Quercus ilex fruit is widely used in the treatment of various gastrointestinal disorders, including diarrhea, for its bioactive compounds and astringent property. The current study focuses on the phytochemical characterization of the Q. ilex-aqueous extract (QIAE) and its protective effect against gastroduodenal (GD) ulcer (GDU) produced by absolute ethanol (EtOH) intoxication in adult male Wistar rats. Experimental rats were divided into six groups (n = 6): control, EtOH [95%, 4 g/kg body weight (b.w.)], EtOH + different doses of QIAE (100, 200, and 400 mg/kg, b.w.), and EtOH + Famotidine (FAM, 10 mg/kg, b.w.). Animals were orally pretreated (p.o.) with QIAE for 15 days and intoxicated with a single oral administration of EtOH for 2 h. The findings showed that the QIAE is rich in phenolic-astringent compounds and fibers, and it exhibited a significant scavenging activity on DPPH/ABTS free-radicals with half maximal inhibitory concentration (IC50) values of 177.00 ± 5.11 and 203.9 ± 2.23 μg/mL, respectively. In vivo part, QIAE significantly reduced the GD mucosal injury revealed by edema and leukocyte infiltration of the submucosal layer. GD mucosal homogenates revealed a remarkable increase in endogenous antioxidant enzyme activities (catalase, superoxide dismutase, and glutathione peroxidase) and a decrease in the lipid peroxidation levels (malondialdehyde) in animals pretreated with QIAE compared with the ulcer control group. QIAE exerted significant and dose-dependent anti-GDU protection in the rat model with a more effective action than FAM. The GD protective effect of the QIAE might be related to a direct radical scavenging activity, increased antioxidant enzymes, and depression of lipid peroxidation." @default.
- W4210579596 created "2022-02-08" @default.
- W4210579596 creator A5006945294 @default.
- W4210579596 creator A5008251296 @default.
- W4210579596 creator A5031958487 @default.
- W4210579596 creator A5036166134 @default.
- W4210579596 creator A5079912242 @default.
- W4210579596 creator A5081307583 @default.
- W4210579596 date "2022-01-24" @default.
- W4210579596 modified "2023-09-26" @default.
- W4210579596 title "Prophylactic Protective Action of Aqueous Extract of Green Oak Acorns on Ethanol-Induced Acute Injury to Rat Gastroduodenal Mucosa" @default.
- W4210579596 cites W1538399032 @default.
- W4210579596 cites W1546592314 @default.
- W4210579596 cites W1781949757 @default.
- W4210579596 cites W1960711550 @default.
- W4210579596 cites W1964801668 @default.
- W4210579596 cites W1967128906 @default.
- W4210579596 cites W1968699719 @default.
- W4210579596 cites W1970336470 @default.
- W4210579596 cites W1974121989 @default.
- W4210579596 cites W1974911268 @default.
- W4210579596 cites W1977543987 @default.
- W4210579596 cites W1984829837 @default.
- W4210579596 cites W1986266291 @default.
- W4210579596 cites W1995130337 @default.
- W4210579596 cites W2006065193 @default.
- W4210579596 cites W2010201651 @default.
- W4210579596 cites W2015368577 @default.
- W4210579596 cites W2015950177 @default.
- W4210579596 cites W2022900821 @default.
- W4210579596 cites W2025836972 @default.
- W4210579596 cites W2026125222 @default.
- W4210579596 cites W2029589188 @default.
- W4210579596 cites W2048520838 @default.
- W4210579596 cites W2050519494 @default.
- W4210579596 cites W2050565735 @default.
- W4210579596 cites W2062475374 @default.
- W4210579596 cites W2063861955 @default.
- W4210579596 cites W2066472053 @default.
- W4210579596 cites W2085683576 @default.
- W4210579596 cites W2095460436 @default.
- W4210579596 cites W2132104458 @default.
- W4210579596 cites W2144190078 @default.
- W4210579596 cites W2152651793 @default.
- W4210579596 cites W2161209637 @default.
- W4210579596 cites W2166022684 @default.
- W4210579596 cites W2463078408 @default.
- W4210579596 cites W2557097038 @default.
- W4210579596 cites W2561956545 @default.
- W4210579596 cites W2743717500 @default.
- W4210579596 cites W2749710857 @default.
- W4210579596 cites W2749826714 @default.
- W4210579596 cites W2908381102 @default.
- W4210579596 cites W2942279058 @default.
- W4210579596 cites W2956285341 @default.
- W4210579596 cites W2977966731 @default.
- W4210579596 cites W3118903871 @default.
- W4210579596 cites W3203579908 @default.
- W4210579596 cites W4205407119 @default.
- W4210579596 cites W74383462 @default.
- W4210579596 doi "https://doi.org/10.1089/jmf.2021.0076" @default.
- W4210579596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35076295" @default.
- W4210579596 hasPublicationYear "2022" @default.
- W4210579596 type Work @default.
- W4210579596 citedByCount "0" @default.
- W4210579596 crossrefType "journal-article" @default.
- W4210579596 hasAuthorship W4210579596A5006945294 @default.
- W4210579596 hasAuthorship W4210579596A5008251296 @default.
- W4210579596 hasAuthorship W4210579596A5031958487 @default.
- W4210579596 hasAuthorship W4210579596A5036166134 @default.
- W4210579596 hasAuthorship W4210579596A5079912242 @default.
- W4210579596 hasAuthorship W4210579596A5081307583 @default.
- W4210579596 hasConcept C126322002 @default.
- W4210579596 hasConcept C185592680 @default.
- W4210579596 hasConcept C2775838275 @default.
- W4210579596 hasConcept C2778004101 @default.
- W4210579596 hasConcept C2778401633 @default.
- W4210579596 hasConcept C2778760513 @default.
- W4210579596 hasConcept C2778979269 @default.
- W4210579596 hasConcept C2780829032 @default.
- W4210579596 hasConcept C2780886150 @default.
- W4210579596 hasConcept C2781031786 @default.
- W4210579596 hasConcept C2781401929 @default.
- W4210579596 hasConcept C55493867 @default.
- W4210579596 hasConcept C71924100 @default.
- W4210579596 hasConcept C98274493 @default.
- W4210579596 hasConceptScore W4210579596C126322002 @default.
- W4210579596 hasConceptScore W4210579596C185592680 @default.
- W4210579596 hasConceptScore W4210579596C2775838275 @default.
- W4210579596 hasConceptScore W4210579596C2778004101 @default.
- W4210579596 hasConceptScore W4210579596C2778401633 @default.
- W4210579596 hasConceptScore W4210579596C2778760513 @default.
- W4210579596 hasConceptScore W4210579596C2778979269 @default.
- W4210579596 hasConceptScore W4210579596C2780829032 @default.
- W4210579596 hasConceptScore W4210579596C2780886150 @default.
- W4210579596 hasConceptScore W4210579596C2781031786 @default.
- W4210579596 hasConceptScore W4210579596C2781401929 @default.
- W4210579596 hasConceptScore W4210579596C55493867 @default.
- W4210579596 hasConceptScore W4210579596C71924100 @default.
- W4210579596 hasConceptScore W4210579596C98274493 @default.