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- W4210584037 endingPage "1240" @default.
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- W4210584037 abstract "Venous thrombosis is a frequent complication in cancer and is associated with high morbidity and mortality. Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related death worldwide, and it is associated with preexisting cirrhosis in 90% of cases. Patients with cirrhosis acquire complex alterations in their haemostatic system that may predispose them to bleed or thrombotic complications. There is growing evidence that HCC may tilt the haemostatic equilibrium in cirrhosis towards hypercoagulability, thus increasing the risk of venous thrombosis. Previously described mechanisms of HCC-driven thrombophilia include thrombocytosis and increased platelet activation/function, increased fibrinogen concentration/polymerization, enhanced thrombin generation, hypofibrinolysis, and release of tissue factor-expressing microvesicles. Nevertheless, there are currently no specific guidelines on risk stratification and management of thromboprophylaxis in patients with cirrhosis and HCC. Our review endeavours to summarize the latest findings on epidemiology, risk factors and pathogenesis of non-malignant venous thrombosis in patients with cirrhosis and HCC, and provide evidence in support of tailored management of thrombotic risk in these patients." @default.
- W4210584037 created "2022-02-08" @default.
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- W4210584037 creator A5065572516 @default.
- W4210584037 date "2022-02-21" @default.
- W4210584037 modified "2023-09-30" @default.
- W4210584037 title "Haemostatic alterations in patients with cirrhosis and hepatocellular carcinoma: laboratory evidence and clinical implications" @default.
- W4210584037 cites W145724464 @default.
- W4210584037 cites W1829489326 @default.
- W4210584037 cites W1967832446 @default.
- W4210584037 cites W1968909791 @default.
- W4210584037 cites W1971837077 @default.
- W4210584037 cites W1975231763 @default.
- W4210584037 cites W1976182266 @default.
- W4210584037 cites W1982322211 @default.
- W4210584037 cites W1989515923 @default.
- W4210584037 cites W1992417406 @default.
- W4210584037 cites W1995391277 @default.
- W4210584037 cites W1996600303 @default.
- W4210584037 cites W2007086823 @default.
- W4210584037 cites W2020579106 @default.
- W4210584037 cites W2023902889 @default.
- W4210584037 cites W2028525116 @default.
- W4210584037 cites W2047530425 @default.
- W4210584037 cites W2050624503 @default.
- W4210584037 cites W2051639931 @default.
- W4210584037 cites W2054324054 @default.
- W4210584037 cites W2056187496 @default.
- W4210584037 cites W2056986368 @default.
- W4210584037 cites W2066351383 @default.
- W4210584037 cites W2072212394 @default.
- W4210584037 cites W2073212944 @default.
- W4210584037 cites W2078461439 @default.
- W4210584037 cites W2080453532 @default.
- W4210584037 cites W2088870023 @default.
- W4210584037 cites W2089422120 @default.
- W4210584037 cites W2093389482 @default.
- W4210584037 cites W2094486696 @default.
- W4210584037 cites W2099755736 @default.
- W4210584037 cites W2103029594 @default.
- W4210584037 cites W2104906217 @default.
- W4210584037 cites W2121354606 @default.
- W4210584037 cites W2121402632 @default.
- W4210584037 cites W2133573467 @default.
- W4210584037 cites W2135283537 @default.
- W4210584037 cites W2136977965 @default.
- W4210584037 cites W2145791480 @default.
- W4210584037 cites W2163608188 @default.
- W4210584037 cites W2166805191 @default.
- W4210584037 cites W2169418185 @default.
- W4210584037 cites W2180726212 @default.
- W4210584037 cites W2186622788 @default.
- W4210584037 cites W2277004004 @default.
- W4210584037 cites W2313284959 @default.
- W4210584037 cites W2313584887 @default.
- W4210584037 cites W2328838065 @default.
- W4210584037 cites W2330004628 @default.
- W4210584037 cites W2345653290 @default.
- W4210584037 cites W2399856285 @default.
- W4210584037 cites W2400224825 @default.
- W4210584037 cites W2402034151 @default.
- W4210584037 cites W2474977599 @default.
- W4210584037 cites W2546046192 @default.
- W4210584037 cites W2565602318 @default.
- W4210584037 cites W2593500728 @default.
- W4210584037 cites W2605248708 @default.
- W4210584037 cites W2610258648 @default.
- W4210584037 cites W2619705272 @default.
- W4210584037 cites W2688302150 @default.
- W4210584037 cites W2723709496 @default.
- W4210584037 cites W2786085951 @default.
- W4210584037 cites W2791662285 @default.
- W4210584037 cites W2801699702 @default.
- W4210584037 cites W2809404554 @default.
- W4210584037 cites W2884377862 @default.
- W4210584037 cites W2884543004 @default.
- W4210584037 cites W2886985238 @default.
- W4210584037 cites W2887652528 @default.
- W4210584037 cites W2891791004 @default.
- W4210584037 cites W2893985403 @default.
- W4210584037 cites W2901233119 @default.
- W4210584037 cites W2902078827 @default.
- W4210584037 cites W2908573150 @default.
- W4210584037 cites W2914393565 @default.
- W4210584037 cites W2917722773 @default.
- W4210584037 cites W2935121430 @default.
- W4210584037 cites W2938919424 @default.
- W4210584037 cites W2955767720 @default.
- W4210584037 cites W2958659517 @default.
- W4210584037 cites W2966354200 @default.
- W4210584037 cites W2972019042 @default.
- W4210584037 cites W2980391564 @default.
- W4210584037 cites W2990602950 @default.