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- W4210585536 abstract "Systemic reactions to insect stings are reported by 3% of adults and can be fatal even on the first reaction. Large local reactions are more frequent than systemic reactions, but rarely dangerous. The chance of a systemic reaction to a sting is low (5%–10%) in children and adults with a history of large local reactions or mild (cutaneous) systemic reactions, and varies between 30% and 65% in those with previous moderate-to-severe systemic reactions, depending on the severity of previous sting reactions. Venom sensitization can be detected in 20% of normal adults, most of whom are asymptomatic, so the history is most important in clinical evaluation. Venom skin tests are most sensitive for diagnosis, but the serum-specific immunoglobulin E (IgE) test is an important complementary test. The level of venom-IgE detected by the skin test or serum test does not, however, reliably predict the severity of a sting reaction. Baseline serum tryptase is elevated in many patients with sting anaphylaxis, and should be evaluated as a predictor of severe reactions. Venom immunotherapy is safe and is 75% to 98% effective in preventing sting anaphylaxis; it also significantly reduces the risk of large local reactions. Most patients can discontinue treatment after 5 years, with very low residual risk of a severe sting reaction." @default.
- W4210585536 created "2022-02-08" @default.
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- W4210585536 date "2022-01-01" @default.
- W4210585536 modified "2023-09-27" @default.
- W4210585536 title "Insect Allergy" @default.
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- W4210585536 doi "https://doi.org/10.1016/b978-0-323-80912-2.00015-9" @default.
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