FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210588363> ?p ?o ?g. }

• W4210588363 abstract "HLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was initially described at the maternal-fetal interface, and it was later found that this molecule was constitutively expressed on certain immuneprivileged tissues, such as cornea, endothelial and erythroid precursors, and thymus. The immunosuppressive effect of HLA-G is exerted through the interaction with its cognate receptors, expressed on immunocompetent cells, like ILT2, expressed on NK, B, T cells and APCs; ILT4, on APCs; KIR, found on the surface of NK cells; and finally, the co-receptor CD8. Because of these immunomodulatory functions, HLA-G has been involved in several processes, amongst which organ transplantation, viral infections, cancer progression, and autoimmunity. HLA-G neo-expression on tumors has been recently described in several types of malignancies. In fact, tumor progression is tightly linked to the presence of the molecule, as it exerts its tolerogenic function, inhibiting the cells of the immune system and favoring tumor escape. Several polymorphisms in the 3'UTR region condition changes in HLA-G expression (14bp and +3142C/G, among others), which have been associated with both the development and outcome of patients with different tumor types. Also, in recent years, several studies have shown that HLA-G plays an important role in the control of autoimmune diseases. The ability of HLA-G to limit the progression of these diseases has been confirmed and, in fact, levels of the molecule and several of its polymorphisms have been associated with increased susceptibility to the development of autoimmune diseases, as well as increased disease severity. Thus, modulating HLA-G expression in target tissues of oncology patients or patients with autoimmune diseases may be potential therapeutic approaches to treat these pathological conditions." @default.
• W4210588363 created "2022-02-08" @default.
• W4210588363 creator A5018022250 @default.
• W4210588363 creator A5031662755 @default.
• W4210588363 creator A5035391740 @default.
• W4210588363 creator A5037149575 @default.
• W4210588363 creator A5046028175 @default.
• W4210588363 creator A5057619011 @default.
• W4210588363 creator A5064593570 @default.
• W4210588363 creator A5079182198 @default.
• W4210588363 creator A5079756378 @default.
• W4210588363 creator A5086026365 @default.
• W4210588363 creator A5086882760 @default.
• W4210588363 date "2022-01-27" @default.
• W4210588363 modified "2023-10-18" @default.
• W4210588363 title "HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease" @default.
• W4210588363 cites W1480265130 @default.
• W4210588363 cites W1544881505 @default.
• W4210588363 cites W1714721500 @default.
• W4210588363 cites W1724951371 @default.
• W4210588363 cites W1794357844 @default.
• W4210588363 cites W1931291333 @default.
• W4210588363 cites W1964363433 @default.
• W4210588363 cites W1965043083 @default.
• W4210588363 cites W1967263426 @default.
• W4210588363 cites W1967783913 @default.
• W4210588363 cites W1970410047 @default.
• W4210588363 cites W1973675832 @default.
• W4210588363 cites W1975302980 @default.
• W4210588363 cites W1976554463 @default.
• W4210588363 cites W1978295388 @default.
• W4210588363 cites W1985043455 @default.
• W4210588363 cites W1985965155 @default.
• W4210588363 cites W1986672594 @default.
• W4210588363 cites W1992208836 @default.
• W4210588363 cites W1997922708 @default.
• W4210588363 cites W2001157494 @default.
• W4210588363 cites W2002982888 @default.
• W4210588363 cites W2004896918 @default.
• W4210588363 cites W20076770 @default.
• W4210588363 cites W2013143312 @default.
• W4210588363 cites W2014208459 @default.
• W4210588363 cites W2014901519 @default.
• W4210588363 cites W2016249920 @default.
• W4210588363 cites W2017847710 @default.
• W4210588363 cites W2020090091 @default.
• W4210588363 cites W2021902701 @default.
• W4210588363 cites W2023906991 @default.
• W4210588363 cites W2026053348 @default.
• W4210588363 cites W2026949664 @default.
• W4210588363 cites W2028695120 @default.
• W4210588363 cites W2035771736 @default.
• W4210588363 cites W2037916071 @default.
• W4210588363 cites W2039339794 @default.
• W4210588363 cites W2044366856 @default.
• W4210588363 cites W2048332030 @default.
• W4210588363 cites W2050955309 @default.
• W4210588363 cites W2056939150 @default.
• W4210588363 cites W2067696007 @default.
• W4210588363 cites W2069032846 @default.
• W4210588363 cites W2069307120 @default.
• W4210588363 cites W2069904417 @default.
• W4210588363 cites W2079963629 @default.
• W4210588363 cites W2083306286 @default.
• W4210588363 cites W2088513266 @default.
• W4210588363 cites W2088756657 @default.
• W4210588363 cites W2102151740 @default.
• W4210588363 cites W2103333248 @default.
• W4210588363 cites W2105267515 @default.
• W4210588363 cites W2108463809 @default.
• W4210588363 cites W2108848387 @default.
• W4210588363 cites W2112773756 @default.
• W4210588363 cites W2113047034 @default.
• W4210588363 cites W2114261647 @default.
• W4210588363 cites W2115158275 @default.
• W4210588363 cites W2115672176 @default.
• W4210588363 cites W2117497316 @default.
• W4210588363 cites W2127924037 @default.
• W4210588363 cites W2130443831 @default.
• W4210588363 cites W2130997583 @default.
• W4210588363 cites W2134627981 @default.
• W4210588363 cites W2135978944 @default.
• W4210588363 cites W2147391835 @default.
• W4210588363 cites W2149493322 @default.
• W4210588363 cites W2153505850 @default.
• W4210588363 cites W2154521168 @default.
• W4210588363 cites W2166126168 @default.
• W4210588363 cites W2178798753 @default.
• W4210588363 cites W2187943673 @default.
• W4210588363 cites W2229869381 @default.
• W4210588363 cites W2274425870 @default.
• W4210588363 cites W2288499212 @default.
• W4210588363 cites W2318212002 @default.
• W4210588363 cites W2406710897 @default.
• W4210588363 cites W2408123952 @default.
• W4210588363 cites W2516779495 @default.
• W4210588363 cites W2533471969 @default.
• W4210588363 cites W2599491619 @default.
• W4210588363 cites W2630573111 @default.
• W4210588363 cites W2750228412 @default.

• next