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- W4210588589 abstract "Metabolite-mediated protein posttranslational modifications (PTM) represent highly evolutionarily conserved mechanisms by which metabolic networks participate in fine-tuning diverse cellular biological activities. Modification of proteins with the metabolite UDP-N-acetylglucosamine (UDP-GlcNAc), known as protein O -GlcNAcylation, is one well-defined form of PTM that is catalyzed by a single pair of enzymes, O -GlcNAc transferase (OGT) and O -GlcNAcase (OGA). Previous studies have discovered critical roles of protein O -GlcNAcylation in many fundamental biological activities via modifying numerous nuclear and cytoplasmic proteins. A common mechanism by which O -GlcNAc affects protein function is through the cross-regulation between protein O -GlcNAcylation and phosphorylation. This is of particular importance to innate immune cell functions due to the essential role of protein phosphorylation in regulating many aspects of innate immune signaling. Indeed, as an integral component of cellular metabolic network, profound alteration in protein O -GlcNAcylation has been documented following the activation of innate immune cells. Accumulating evidence suggests that O -GlcNAcylation of proteins involved in the NF-κB pathway and other inflammation-associated signaling pathways plays an essential role in regulating the functionality of innate immune cells. Here, we summarize recent studies focusing on the role of protein O -GlcNAcylation in regulating the NF-κB pathway, other innate immune signaling responses and its disease relevance." @default.
- W4210588589 created "2022-02-08" @default.
- W4210588589 creator A5003718473 @default.
- W4210588589 creator A5021569070 @default.
- W4210588589 creator A5047650515 @default.
- W4210588589 date "2022-02-03" @default.
- W4210588589 modified "2023-09-30" @default.
- W4210588589 title "Protein O-GlcNAcylation Regulates Innate Immune Cell Function" @default.
- W4210588589 cites W1574150623 @default.
- W4210588589 cites W1603490726 @default.
- W4210588589 cites W1652316604 @default.
- W4210588589 cites W1835020024 @default.
- W4210588589 cites W1850224498 @default.
- W4210588589 cites W1919712230 @default.
- W4210588589 cites W1989476631 @default.
- W4210588589 cites W1999218213 @default.
- W4210588589 cites W2002888609 @default.
- W4210588589 cites W2008955645 @default.
- W4210588589 cites W2017548268 @default.
- W4210588589 cites W2022687771 @default.
- W4210588589 cites W2052162377 @default.
- W4210588589 cites W2053017792 @default.
- W4210588589 cites W2057967679 @default.
- W4210588589 cites W2069463866 @default.
- W4210588589 cites W2073900053 @default.
- W4210588589 cites W2078730804 @default.
- W4210588589 cites W2079599967 @default.
- W4210588589 cites W2080462728 @default.
- W4210588589 cites W2096443403 @default.
- W4210588589 cites W2097670917 @default.
- W4210588589 cites W2098687851 @default.
- W4210588589 cites W2099329307 @default.
- W4210588589 cites W2107089340 @default.
- W4210588589 cites W2115617484 @default.
- W4210588589 cites W2116666113 @default.
- W4210588589 cites W2122044177 @default.
- W4210588589 cites W2126711569 @default.
- W4210588589 cites W2130472257 @default.
- W4210588589 cites W2130776456 @default.
- W4210588589 cites W2140409722 @default.
- W4210588589 cites W2146191481 @default.
- W4210588589 cites W2156322986 @default.
- W4210588589 cites W2158953193 @default.
- W4210588589 cites W2159611259 @default.
- W4210588589 cites W2180342052 @default.
- W4210588589 cites W2206617731 @default.
- W4210588589 cites W2292177117 @default.
- W4210588589 cites W2340906209 @default.
- W4210588589 cites W2343796589 @default.
- W4210588589 cites W2467178923 @default.
- W4210588589 cites W2468925656 @default.
- W4210588589 cites W2522365421 @default.
- W4210588589 cites W2551329787 @default.
- W4210588589 cites W2560156171 @default.
- W4210588589 cites W2574819148 @default.
- W4210588589 cites W2592844806 @default.
- W4210588589 cites W2605654755 @default.
- W4210588589 cites W2611694282 @default.
- W4210588589 cites W2612033696 @default.
- W4210588589 cites W2613539552 @default.
- W4210588589 cites W2735527928 @default.
- W4210588589 cites W2755330602 @default.
- W4210588589 cites W2765688680 @default.
- W4210588589 cites W2808548669 @default.
- W4210588589 cites W2895737508 @default.
- W4210588589 cites W2898855247 @default.
- W4210588589 cites W2905020668 @default.
- W4210588589 cites W2908901070 @default.
- W4210588589 cites W2910499089 @default.
- W4210588589 cites W2911143204 @default.
- W4210588589 cites W2913871604 @default.
- W4210588589 cites W2914505828 @default.
- W4210588589 cites W2921875691 @default.
- W4210588589 cites W2944683054 @default.
- W4210588589 cites W2952757683 @default.
- W4210588589 cites W2959449984 @default.
- W4210588589 cites W2970388083 @default.
- W4210588589 cites W2971228383 @default.
- W4210588589 cites W2972985729 @default.
- W4210588589 cites W2989487802 @default.
- W4210588589 cites W2995084017 @default.
- W4210588589 cites W2995112289 @default.
- W4210588589 cites W3001317991 @default.
- W4210588589 cites W3016942538 @default.
- W4210588589 cites W3038537348 @default.
- W4210588589 cites W3083652177 @default.
- W4210588589 cites W3094704145 @default.
- W4210588589 cites W3111603242 @default.
- W4210588589 cites W3129850565 @default.
- W4210588589 cites W3160938771 @default.
- W4210588589 cites W3203904369 @default.
- W4210588589 cites W4235374798 @default.
- W4210588589 doi "https://doi.org/10.3389/fimmu.2022.805018" @default.
- W4210588589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35185892" @default.
- W4210588589 hasPublicationYear "2022" @default.
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