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- W4210589225 abstract "Plant flavonoids are secondary metabolites containing a benzo-γ-pyrone structure, which are widely present in plants and have a variety of physiological and pharmacological activities. However, current flavonoid production from plant extraction or chemical synthesis does not meet the requirements of green and sustainable development. Fortunately, microbial synthesis of flavonoids has shown the potential for large-scale production with the advantages of being controllable and environmentally friendly, and a variety of microorganisms have been developed as microbial cell factories (MCFs) to synthesize plant flavonoids owing to the feasibility of genetic manipulations. However, most of MCFs have not yet been commercialized and industrialized because of the challenges posed by unbalanced metabolic flux among various pathways and conflict between cell growth and production. Here, strategies for coping with the challenges are summarized in terms of enzymes, pathways, metabolic networks, host cells. And combined with protein structure prediction, de novo protein design, artificial intelligence (AI), biocatalytic retrosynthesis, and intelligent stress resistance, it provides new insights for the high efficient production of plant flavonoids and other plant natural products in MCFs." @default.
- W4210589225 created "2022-02-08" @default.
- W4210589225 creator A5037712945 @default.
- W4210589225 creator A5042730231 @default.
- W4210589225 creator A5063187488 @default.
- W4210589225 creator A5069277193 @default.
- W4210589225 creator A5090810357 @default.
- W4210589225 date "2022-03-01" @default.
- W4210589225 modified "2023-10-17" @default.
- W4210589225 title "High efficient production of plant flavonoids by microbial cell factories: Challenges and opportunities" @default.
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