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- W4210595038 abstract "Significance Human angiotensin-converting enzyme 2 (ACE2) is the most widely known entry receptor for SARS-CoV-2. The possible involvement of other cellular components in viral entry mechanisms remains unknown. Vimentin is expressed in human endothelial cells, binds to SARS-CoV-2-spike, and expedites SARS-CoV-2 entry. Treatment of lung ACE2/A549 carcinoma cells with purified vimentin or coculture of ACE2/A549 cells with HEK-293 cells expressing vimentin increased ACE2-dependent viral entry. CR3022 antibody blocked vimentin interaction with SARS-CoV-2-spike and inhibited SARS-CoV-2 entry. Vimentin could facilitate SARS-CoV-2 infection and contribute to vascular complications associated with COVID-19." @default.
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- W4210595038 date "2022-01-25" @default.
- W4210595038 modified "2023-10-14" @default.
- W4210595038 title "Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells" @default.
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- W4210595038 doi "https://doi.org/10.1073/pnas.2113874119" @default.
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