FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210596406> ?p ?o ?g. }

• W4210596406 endingPage "167" @default.
• W4210596406 startingPage "167" @default.
• W4210596406 abstract "The combination of ceftazidime/avibactam (CZA) is a novel β-lactam/β-lactamase inhibitor with activity against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacterales. Emerging cases caused by CZA-resistant strains that produce variants of KPC genes have already been reported worldwide. However, to the best of our knowledge, no CZA-resistant strains were reported in Portugal. In September 2019, a K. pneumoniae CZA-resistant strain was collected from ascitic fluid at a surgery ward of a tertiary University Hospital Center in Lisboa, Portugal. The strain was resistant to ceftazidime/avibactam, as well as to ceftazidime, cefoxitin, gentamicin, amoxicillin/clavulanic acid, and ertapenem, being susceptible to imipenem and tigecycline. A hypermucoviscosity phenotype was confirmed by string test. Whole-genome sequencing (WGS) analysis revealed the presence of an ST13 KPC70-producing K. pneumoniae, a KPC-3 variant, differing in two amino-acid substitutions (D179Y and T263A). The D179Y mutation in the KPC Ω-loop region is the most common amino-acid substitution in KPC-2 and KPC-3, further leading to CZA resistance. The second mutation causes a KPC-70 variant in which threonine replaces alanine (T263A). The CZA-resistant strain showed the capsular locus KL3 and antigen locus O1v2. Other important virulence factors were identified: fimbrial adhesins type 1 and type 3, as well as the cluster of iron uptake systems aerobactin, enterobactin, salmochelin, and yersiniabactin included in integrative conjugative element 10 (ICEKp10) with the genotoxin colibactin cluster. Herein, we report the molecular characterization of the first hypervirulent CZA-resistant ST13 KPC-70-producing K. pneumoniae strain in Portugal. The emergence of CZA-resistant strains might pose a serious threat to public health and suggests an urgent need for enhanced clinical awareness and epidemiologic surveillance." @default.
• W4210596406 created "2022-02-08" @default.
• W4210596406 creator A5013598905 @default.
• W4210596406 creator A5014661338 @default.
• W4210596406 creator A5037982911 @default.
• W4210596406 creator A5053307993 @default.
• W4210596406 creator A5079007538 @default.
• W4210596406 creator A5085473648 @default.
• W4210596406 creator A5090859493 @default.
• W4210596406 date "2022-01-27" @default.
• W4210596406 modified "2023-10-13" @default.
• W4210596406 title "First Description of Ceftazidime/Avibactam Resistance in a ST13 KPC-70-Producing Klebsiella pneumoniae Strain from Portugal" @default.
• W4210596406 cites W151341992 @default.
• W4210596406 cites W1992234072 @default.
• W4210596406 cites W2003545535 @default.
• W4210596406 cites W2015455333 @default.
• W4210596406 cites W2061729558 @default.
• W4210596406 cites W2088527369 @default.
• W4210596406 cites W2104518072 @default.
• W4210596406 cites W2115280192 @default.
• W4210596406 cites W2123013243 @default.
• W4210596406 cites W2129805236 @default.
• W4210596406 cites W2134861388 @default.
• W4210596406 cites W2136653513 @default.
• W4210596406 cites W2142343447 @default.
• W4210596406 cites W2157743405 @default.
• W4210596406 cites W2167789296 @default.
• W4210596406 cites W2436758556 @default.
• W4210596406 cites W2443415468 @default.
• W4210596406 cites W2565726837 @default.
• W4210596406 cites W2590149742 @default.
• W4210596406 cites W2591642302 @default.
• W4210596406 cites W2612800330 @default.
• W4210596406 cites W2618911885 @default.
• W4210596406 cites W2725848895 @default.
• W4210596406 cites W2766370714 @default.
• W4210596406 cites W2793118730 @default.
• W4210596406 cites W2794121289 @default.
• W4210596406 cites W2801851274 @default.
• W4210596406 cites W2807053173 @default.
• W4210596406 cites W2899841051 @default.
• W4210596406 cites W2903883567 @default.
• W4210596406 cites W2906107854 @default.
• W4210596406 cites W2918206043 @default.
• W4210596406 cites W2945505394 @default.
• W4210596406 cites W2950976728 @default.
• W4210596406 cites W2965055681 @default.
• W4210596406 cites W2966698394 @default.
• W4210596406 cites W2971823933 @default.
• W4210596406 cites W2974520474 @default.
• W4210596406 cites W2985478486 @default.
• W4210596406 cites W2987013299 @default.
• W4210596406 cites W2995664785 @default.
• W4210596406 cites W3005968613 @default.
• W4210596406 cites W3012489270 @default.
• W4210596406 cites W3094338265 @default.
• W4210596406 cites W3110931087 @default.
• W4210596406 cites W3112997089 @default.
• W4210596406 cites W3122080139 @default.
• W4210596406 cites W3137942377 @default.
• W4210596406 cites W3158695052 @default.
• W4210596406 cites W3164493875 @default.
• W4210596406 cites W3181261361 @default.
• W4210596406 cites W3181757523 @default.
• W4210596406 cites W3188173177 @default.
• W4210596406 cites W4205103838 @default.
• W4210596406 doi "https://doi.org/10.3390/antibiotics11020167" @default.
• W4210596406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35203770" @default.
• W4210596406 hasPublicationYear "2022" @default.
• W4210596406 type Work @default.
• W4210596406 citedByCount "5" @default.
• W4210596406 countsByYear W42105964062022 @default.
• W4210596406 countsByYear W42105964062023 @default.
• W4210596406 crossrefType "journal-article" @default.
• W4210596406 hasAuthorship W4210596406A5013598905 @default.
• W4210596406 hasAuthorship W4210596406A5014661338 @default.
• W4210596406 hasAuthorship W4210596406A5037982911 @default.
• W4210596406 hasAuthorship W4210596406A5053307993 @default.
• W4210596406 hasAuthorship W4210596406A5079007538 @default.
• W4210596406 hasAuthorship W4210596406A5085473648 @default.
• W4210596406 hasAuthorship W4210596406A5090859493 @default.
• W4210596406 hasBestOaLocation W42105964061 @default.
• W4210596406 hasConcept C104317684 @default.
• W4210596406 hasConcept C2775933652 @default.
• W4210596406 hasConcept C2776968632 @default.
• W4210596406 hasConcept C2777058267 @default.
• W4210596406 hasConcept C2777406300 @default.
• W4210596406 hasConcept C2777637488 @default.
• W4210596406 hasConcept C2777821550 @default.
• W4210596406 hasConcept C2778368673 @default.
• W4210596406 hasConcept C2778487981 @default.
• W4210596406 hasConcept C2778910516 @default.
• W4210596406 hasConcept C2779454058 @default.
• W4210596406 hasConcept C2779631663 @default.
• W4210596406 hasConcept C2779708577 @default.
• W4210596406 hasConcept C501593827 @default.
• W4210596406 hasConcept C523546767 @default.
• W4210596406 hasConcept C54355233 @default.

• next