Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210596927> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4210596927 abstract "Introduction: Successful interventions to prevent cerebrovascular disease and stroke require early identification of persons at risk before clinical manifestation of disease. Methods: The predictive value of biological age (BA) was assessed as an early indicator for cerebrovascular disease and risk of first-ever intracerebral hemorrhage (ICH) and cerebral infarction (CI) in advanced age. BA was also compared with commonly used biomarkers including tau and Aβ40 and Aβ42. The study included Individuals who consented for blood draw and follow-up in the Rotterdam Study. Biological age was computed using structural equation modelling. The algorithm integrates biomarkers that represent six body systems involved in overall cerebrovascular health including metabolic function, cardiac function, lung function, kidney function, liver function, immunity, and inflammation. Time to event analysis was conducted using Cox-regression models. Prediction analysis was conducted using Harrel’s C and Area under the receiver operating characteristic curve. Results: The sample included a total of 1699 individuals at baseline followed up over a median of 11 years. During a period of 15, 780 and 16, 172 person-years a total of 17 first-ever intracerebral hemorrhage and 83 cerebral infarction cases occurred. In time-to-event analysis, BA showed higher magnitude of associations with ICH compared to CA (HR BA-ICH: 2.30, 95% CI: 1.20, 4.30; HR CA-ICH: 1.40, 95% CI: 0.76, 2.53) and higher precision with CI (HR BA-CI: 1.30, 95% CI: 1.01,1.75; HR CA-CI: 1.90, 95% CI: 1.48, 2.66). BA outperformed CA for prediction of ICH (AUC: 0.68 vs 0.53; Harrel’s C: 0.72 vs 0.53) and for CI (AUC:0.63 vs 0.62; Harrel’s C: 0.68 vs 0.67). Conclusion: Biological aging based on integrated physiology biomarkers provides a novel tool for monitoring and identification of persons at highest risk of cerebrovascular disease in advanced age. Wider applicability requires extension of such findings from the general population to the clinical and primary care settings." @default.
- W4210596927 created "2022-02-08" @default.
- W4210596927 creator A5010879652 @default.
- W4210596927 creator A5014405563 @default.
- W4210596927 creator A5024948628 @default.
- W4210596927 creator A5036303967 @default.
- W4210596927 creator A5039611937 @default.
- W4210596927 creator A5055695678 @default.
- W4210596927 creator A5061174828 @default.
- W4210596927 creator A5066575559 @default.
- W4210596927 creator A5076290987 @default.
- W4210596927 date "2022-02-01" @default.
- W4210596927 modified "2023-09-27" @default.
- W4210596927 title "Abstract TP12: Biological Age For Prediction Of First-ever Intracerebral Hemorrhage And Cerebral Infarction In Advanced Age" @default.
- W4210596927 doi "https://doi.org/10.1161/str.53.suppl_1.tp12" @default.
- W4210596927 hasPublicationYear "2022" @default.
- W4210596927 type Work @default.
- W4210596927 citedByCount "0" @default.
- W4210596927 crossrefType "journal-article" @default.
- W4210596927 hasAuthorship W4210596927A5010879652 @default.
- W4210596927 hasAuthorship W4210596927A5014405563 @default.
- W4210596927 hasAuthorship W4210596927A5024948628 @default.
- W4210596927 hasAuthorship W4210596927A5036303967 @default.
- W4210596927 hasAuthorship W4210596927A5039611937 @default.
- W4210596927 hasAuthorship W4210596927A5055695678 @default.
- W4210596927 hasAuthorship W4210596927A5061174828 @default.
- W4210596927 hasAuthorship W4210596927A5066575559 @default.
- W4210596927 hasAuthorship W4210596927A5076290987 @default.
- W4210596927 hasConcept C126322002 @default.
- W4210596927 hasConcept C127413603 @default.
- W4210596927 hasConcept C164705383 @default.
- W4210596927 hasConcept C2777094939 @default.
- W4210596927 hasConcept C2777736543 @default.
- W4210596927 hasConcept C2777798775 @default.
- W4210596927 hasConcept C2779450755 @default.
- W4210596927 hasConcept C2780645631 @default.
- W4210596927 hasConcept C500558357 @default.
- W4210596927 hasConcept C541997718 @default.
- W4210596927 hasConcept C58471807 @default.
- W4210596927 hasConcept C71924100 @default.
- W4210596927 hasConcept C78519656 @default.
- W4210596927 hasConceptScore W4210596927C126322002 @default.
- W4210596927 hasConceptScore W4210596927C127413603 @default.
- W4210596927 hasConceptScore W4210596927C164705383 @default.
- W4210596927 hasConceptScore W4210596927C2777094939 @default.
- W4210596927 hasConceptScore W4210596927C2777736543 @default.
- W4210596927 hasConceptScore W4210596927C2777798775 @default.
- W4210596927 hasConceptScore W4210596927C2779450755 @default.
- W4210596927 hasConceptScore W4210596927C2780645631 @default.
- W4210596927 hasConceptScore W4210596927C500558357 @default.
- W4210596927 hasConceptScore W4210596927C541997718 @default.
- W4210596927 hasConceptScore W4210596927C58471807 @default.
- W4210596927 hasConceptScore W4210596927C71924100 @default.
- W4210596927 hasConceptScore W4210596927C78519656 @default.
- W4210596927 hasIssue "Suppl_1" @default.
- W4210596927 hasLocation W42105969271 @default.
- W4210596927 hasOpenAccess W4210596927 @default.
- W4210596927 hasPrimaryLocation W42105969271 @default.
- W4210596927 hasRelatedWork W2072561903 @default.
- W4210596927 hasRelatedWork W2101094915 @default.
- W4210596927 hasRelatedWork W2124653669 @default.
- W4210596927 hasRelatedWork W2132952595 @default.
- W4210596927 hasRelatedWork W2168350521 @default.
- W4210596927 hasRelatedWork W2387869598 @default.
- W4210596927 hasRelatedWork W2887480775 @default.
- W4210596927 hasRelatedWork W3146032758 @default.
- W4210596927 hasRelatedWork W3147557850 @default.
- W4210596927 hasRelatedWork W4237429006 @default.
- W4210596927 hasVolume "53" @default.
- W4210596927 isParatext "false" @default.
- W4210596927 isRetracted "false" @default.
- W4210596927 workType "article" @default.