Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210601064> ?p ?o ?g. }
- W4210601064 abstract "The duration of humoral and cellular immune memory following SARS-CoV-2 infection in populations in least developed countries remains understudied but is key to overcome the current SARS-CoV-2 pandemic. Sixty-four Cambodian individuals with laboratory-confirmed infection with asymptomatic or mild/moderate clinical presentation were evaluated for Spike (S)-binding and neutralizing antibodies and antibody effector functions during acute phase of infection and at 6-9 months follow-up. Antigen-specific B cells, CD4+ and CD8+ T cells were characterized, and T cells were interrogated for functionality at late convalescence. Anti-S antibody titers decreased over time, but effector functions mediated by S-specific antibodies remained stable. S- and nucleocapsid (N)-specific B cells could be detected in late convalescence in the activated memory B cell compartment and are mostly IgG+. CD4+ and CD8+ T cell immune memory was maintained to S and membrane (M) protein. Asymptomatic infection resulted in decreased antibody-dependent cellular cytotoxicity (ADCC) and frequency of SARS-CoV-2-specific CD4+ T cells at late convalescence. Whereas anti-S antibodies correlated with S-specific B cells, there was no correlation between T cell response and humoral immune memory. Hence, all aspects of a protective immune response are maintained up to nine months after SARS-CoV-2 infection and in the absence of re-infection." @default.
- W4210601064 created "2022-02-08" @default.
- W4210601064 creator A5007257126 @default.
- W4210601064 creator A5025900296 @default.
- W4210601064 creator A5033376690 @default.
- W4210601064 creator A5043655803 @default.
- W4210601064 creator A5055664477 @default.
- W4210601064 creator A5061312215 @default.
- W4210601064 creator A5061539308 @default.
- W4210601064 creator A5068604161 @default.
- W4210601064 creator A5070867013 @default.
- W4210601064 creator A5071258582 @default.
- W4210601064 creator A5071748928 @default.
- W4210601064 creator A5071921024 @default.
- W4210601064 creator A5072642704 @default.
- W4210601064 creator A5078727650 @default.
- W4210601064 creator A5083289828 @default.
- W4210601064 creator A5090316585 @default.
- W4210601064 creator A5091215215 @default.
- W4210601064 date "2022-02-03" @default.
- W4210601064 modified "2023-10-15" @default.
- W4210601064 title "Robust and Functional Immune Memory Up to 9 Months After SARS-CoV-2 Infection: A Southeast Asian Longitudinal Cohort" @default.
- W4210601064 cites W2099868898 @default.
- W4210601064 cites W2137354517 @default.
- W4210601064 cites W2156049613 @default.
- W4210601064 cites W2749771768 @default.
- W4210601064 cites W2765584638 @default.
- W4210601064 cites W2802098245 @default.
- W4210601064 cites W2805699947 @default.
- W4210601064 cites W2920688815 @default.
- W4210601064 cites W2995806710 @default.
- W4210601064 cites W3001195213 @default.
- W4210601064 cites W3001897055 @default.
- W4210601064 cites W3002108456 @default.
- W4210601064 cites W3004280078 @default.
- W4210601064 cites W3008827533 @default.
- W4210601064 cites W3010441732 @default.
- W4210601064 cites W3012846954 @default.
- W4210601064 cites W3015190630 @default.
- W4210601064 cites W3025320502 @default.
- W4210601064 cites W3027204812 @default.
- W4210601064 cites W3036386821 @default.
- W4210601064 cites W3038792485 @default.
- W4210601064 cites W3039066506 @default.
- W4210601064 cites W3039901154 @default.
- W4210601064 cites W3041450977 @default.
- W4210601064 cites W3042183476 @default.
- W4210601064 cites W3048775784 @default.
- W4210601064 cites W3057728496 @default.
- W4210601064 cites W3081916995 @default.
- W4210601064 cites W3082438395 @default.
- W4210601064 cites W3090928025 @default.
- W4210601064 cites W3094968263 @default.
- W4210601064 cites W3095217725 @default.
- W4210601064 cites W3096867322 @default.
- W4210601064 cites W3098118792 @default.
- W4210601064 cites W3099530525 @default.
- W4210601064 cites W3105885548 @default.
- W4210601064 cites W3107730772 @default.
- W4210601064 cites W3108500958 @default.
- W4210601064 cites W3112389805 @default.
- W4210601064 cites W3112645864 @default.
- W4210601064 cites W3117759033 @default.
- W4210601064 cites W3117773316 @default.
- W4210601064 cites W3118539936 @default.
- W4210601064 cites W3119858919 @default.
- W4210601064 cites W3121008609 @default.
- W4210601064 cites W3121906900 @default.
- W4210601064 cites W3126498743 @default.
- W4210601064 cites W3126966305 @default.
- W4210601064 cites W3127602500 @default.
- W4210601064 cites W3128620152 @default.
- W4210601064 cites W3128918508 @default.
- W4210601064 cites W3129651179 @default.
- W4210601064 cites W3131892506 @default.
- W4210601064 cites W3131938123 @default.
- W4210601064 cites W3133886427 @default.
- W4210601064 cites W3133926412 @default.
- W4210601064 cites W3134099704 @default.
- W4210601064 cites W3134424246 @default.
- W4210601064 cites W3137749340 @default.
- W4210601064 cites W3137992437 @default.
- W4210601064 cites W3138645734 @default.
- W4210601064 cites W3139029545 @default.
- W4210601064 cites W3141930699 @default.
- W4210601064 cites W3143867892 @default.
- W4210601064 cites W3153222280 @default.
- W4210601064 cites W3155608666 @default.
- W4210601064 cites W3157116442 @default.
- W4210601064 cites W3159965848 @default.
- W4210601064 cites W3161511556 @default.
- W4210601064 cites W3163312867 @default.
- W4210601064 cites W3163651782 @default.
- W4210601064 cites W3165191191 @default.
- W4210601064 cites W3167555428 @default.
- W4210601064 cites W3168259929 @default.
- W4210601064 cites W3173863723 @default.
- W4210601064 cites W3178772652 @default.
- W4210601064 cites W3193191879 @default.
- W4210601064 cites W3211396657 @default.