Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210601302> ?p ?o ?g. }
- W4210601302 endingPage "e3001502" @default.
- W4210601302 startingPage "e3001502" @default.
- W4210601302 abstract "Mounting epidemiologic and scientific evidence indicates that many psychiatric disorders originate from a complex interplay between genetics and early life experiences, particularly in the womb. Despite decades of research, our understanding of the precise prenatal and perinatal experiences that increase susceptibility to neurodevelopmental disorders remains incomplete. Sleep apnea (SA) is increasingly common during pregnancy and is characterized by recurrent partial or complete cessations in breathing during sleep. SA causes pathological drops in blood oxygen levels (intermittent hypoxia, IH), often hundreds of times each night. Although SA is known to cause adverse pregnancy and neonatal outcomes, the long-term consequences of maternal SA during pregnancy on brain-based behavioral outcomes and associated neuronal functioning in the offspring remain unknown. We developed a rat model of maternal SA during pregnancy by exposing dams to IH, a hallmark feature of SA, during gestational days 10 to 21 and investigated the consequences on the offspring's forebrain synaptic structure, synaptic function, and behavioral phenotypes across multiples stages of development. Our findings represent a rare example of prenatal factors causing sexually dimorphic behavioral phenotypes associated with excessive (rather than reduced) synapse numbers and implicate hyperactivity of the mammalian target of rapamycin (mTOR) pathway in contributing to the behavioral aberrations. These findings have implications for neuropsychiatric disorders typified by superfluous synapse maintenance that are believed to result, at least in part, from largely unknown insults to the maternal environment." @default.
- W4210601302 created "2022-02-08" @default.
- W4210601302 creator A5005831234 @default.
- W4210601302 creator A5030256600 @default.
- W4210601302 creator A5037820762 @default.
- W4210601302 creator A5045544200 @default.
- W4210601302 creator A5053874663 @default.
- W4210601302 creator A5057272818 @default.
- W4210601302 creator A5061252605 @default.
- W4210601302 creator A5068292790 @default.
- W4210601302 creator A5083734292 @default.
- W4210601302 creator A5085034692 @default.
- W4210601302 creator A5088029540 @default.
- W4210601302 date "2022-02-03" @default.
- W4210601302 modified "2023-10-01" @default.
- W4210601302 title "A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring" @default.
- W4210601302 cites W1521767116 @default.
- W4210601302 cites W1523693806 @default.
- W4210601302 cites W1525073007 @default.
- W4210601302 cites W1533957776 @default.
- W4210601302 cites W1580155665 @default.
- W4210601302 cites W1585385265 @default.
- W4210601302 cites W1798313689 @default.
- W4210601302 cites W1804602290 @default.
- W4210601302 cites W1808780225 @default.
- W4210601302 cites W1879265019 @default.
- W4210601302 cites W1923938661 @default.
- W4210601302 cites W1968071340 @default.
- W4210601302 cites W1970629813 @default.
- W4210601302 cites W1970637701 @default.
- W4210601302 cites W1977197102 @default.
- W4210601302 cites W1980352382 @default.
- W4210601302 cites W1980926695 @default.
- W4210601302 cites W1990087400 @default.
- W4210601302 cites W1990896000 @default.
- W4210601302 cites W1993608966 @default.
- W4210601302 cites W1994206543 @default.
- W4210601302 cites W2004317605 @default.
- W4210601302 cites W2008398629 @default.
- W4210601302 cites W2009334673 @default.
- W4210601302 cites W2009833394 @default.
- W4210601302 cites W2013716914 @default.
- W4210601302 cites W2018228062 @default.
- W4210601302 cites W2021906711 @default.
- W4210601302 cites W2023978077 @default.
- W4210601302 cites W2024431022 @default.
- W4210601302 cites W2029422202 @default.
- W4210601302 cites W2034129855 @default.
- W4210601302 cites W2035016947 @default.
- W4210601302 cites W2040268226 @default.
- W4210601302 cites W2042592767 @default.
- W4210601302 cites W2046220871 @default.
- W4210601302 cites W2046922635 @default.
- W4210601302 cites W2047569375 @default.
- W4210601302 cites W2048843644 @default.
- W4210601302 cites W2052583546 @default.
- W4210601302 cites W2060447620 @default.
- W4210601302 cites W2062278012 @default.
- W4210601302 cites W2065341809 @default.
- W4210601302 cites W2070871404 @default.
- W4210601302 cites W2073798115 @default.
- W4210601302 cites W2074934756 @default.
- W4210601302 cites W2075620073 @default.
- W4210601302 cites W2078002432 @default.
- W4210601302 cites W2081161499 @default.
- W4210601302 cites W2083547139 @default.
- W4210601302 cites W2085037598 @default.
- W4210601302 cites W2087381001 @default.
- W4210601302 cites W2087394955 @default.
- W4210601302 cites W2094236670 @default.
- W4210601302 cites W2095056606 @default.
- W4210601302 cites W2102776209 @default.
- W4210601302 cites W2103163472 @default.
- W4210601302 cites W2122025343 @default.
- W4210601302 cites W2123403550 @default.
- W4210601302 cites W2123923673 @default.
- W4210601302 cites W2125531274 @default.
- W4210601302 cites W2129381979 @default.
- W4210601302 cites W2130407277 @default.
- W4210601302 cites W2133470905 @default.
- W4210601302 cites W2137395087 @default.
- W4210601302 cites W2142654785 @default.
- W4210601302 cites W2143112776 @default.
- W4210601302 cites W2153821084 @default.
- W4210601302 cites W2154965665 @default.
- W4210601302 cites W2154982924 @default.
- W4210601302 cites W2155933706 @default.
- W4210601302 cites W2157276922 @default.
- W4210601302 cites W2160079255 @default.
- W4210601302 cites W2164471705 @default.
- W4210601302 cites W2169980814 @default.
- W4210601302 cites W2205794177 @default.
- W4210601302 cites W2253802357 @default.
- W4210601302 cites W2258704607 @default.
- W4210601302 cites W2266710750 @default.
- W4210601302 cites W2270338484 @default.
- W4210601302 cites W2277433209 @default.
- W4210601302 cites W2281491275 @default.