FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210604509> ?p ?o ?g. }

• W4210604509 endingPage "1559" @default.
• W4210604509 startingPage "1551" @default.
• W4210604509 abstract "Reactive gliosis, characterized by reactive astrocytes and activated microglia, contributes greatly to neurodegeneration throughout the course of Alzheimer disease (AD). Reactive astrocytes overexpress monoamine oxidase B (MAO-B). We characterized the clinical performance of 18F-(S)-(2-methylpyrid-5-yl)-6-[(3-fluoro-2-hydroxy)propoxy]quinoline (18F-SMBT-1), a novel MAO-B PET tracer as a potential surrogate marker of reactive astrogliosis. Methods: Seventy-seven participants-53 who were elderly and cognitively normal, 7 with mild cognitive impairment, 7 with AD, and 10 who were young and cognitively normal-were recruited for the different aspects of the study. Older participants underwent 3-dimensional magnetization-prepared rapid gradient-echo MRI and amyloid-β, tau, and 18F-SMBT-1 PET. To ascertain 18F-SMBT-1 selectivity to MAO-B, 9 participants underwent 2 18F-SMBT-1 scans, before and after receiving 5 mg of selegiline twice daily for 5 d. To compare selectivity, 18F-THK5351 studies were also conducted before and after selegiline. Amyloid-β burden was expressed in centiloids. 18F-SMBT-1 outcomes were expressed as SUV, as well as tissue ratios and binding parameters using the subcortical white matter as a reference region. Results:18F-SMBT-1 showed robust entry into the brain and reversible binding kinetics, with high tracer retention in basal ganglia, intermediate retention in cortical regions, and the lowest retention in cerebellum and white matter, which tightly follows the known regional brain distribution of MAO-B (R2 = 0.84). More than 85% of 18F-SMBT-1 signal was blocked by selegiline across the brain, and in contrast to 18F-THK5351, no residual cortical activity was observed after the selegiline regimen, indicating high selectivity for MAO-B and low nonspecific binding. 18F-SMBT-1 also captured the known MAO-B increases with age, with an annual rate of change (∼2.6%/y) similar to the in vitro rates of change (∼1.9%/y). Quantitative and semiquantitative measures of 18F-SMBT-1 binding were strongly associated (R2 > 0.94), suggesting that a simplified tissue-ratio approach could be used to generate outcome measures. Conclusion:18F-SMBT-1 is a highly selective MAO-B tracer, with low nonspecific binding, high entry into the brain, and reversible kinetics. Moreover, 18F-SMBT-1 brain distribution matches the reported in vitro distribution and captures the known MAO-B increases with age, suggesting that 18F-SMBT-1 can potentially be used as a surrogate marker of reactive astrogliosis. Further validation of these findings with 18F-SMBT-1 will require examination of a much larger series, including participants with mild cognitive impairment and AD." @default.
• W4210604509 created "2022-02-08" @default.
• W4210604509 creator A5000636220 @default.
• W4210604509 creator A5000945121 @default.
• W4210604509 creator A5008078105 @default.
• W4210604509 creator A5017027985 @default.
• W4210604509 creator A5022818431 @default.
• W4210604509 creator A5028540036 @default.
• W4210604509 creator A5035847289 @default.
• W4210604509 creator A5058052951 @default.
• W4210604509 creator A5063415107 @default.
• W4210604509 creator A5065225018 @default.
• W4210604509 creator A5066212403 @default.
• W4210604509 creator A5068192630 @default.
• W4210604509 creator A5072641683 @default.
• W4210604509 creator A5080491480 @default.
• W4210604509 date "2022-01-27" @default.
• W4210604509 modified "2023-10-10" @default.
• W4210604509 title "First-in-Humans Evaluation of ¹⁸F-SMBT-1, a Novel ¹⁸F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis" @default.
• W4210604509 cites W1525558041 @default.
• W4210604509 cites W1727795608 @default.
• W4210604509 cites W1767289909 @default.
• W4210604509 cites W1984009511 @default.
• W4210604509 cites W1988218738 @default.
• W4210604509 cites W1996964516 @default.
• W4210604509 cites W1998126371 @default.
• W4210604509 cites W2004136146 @default.
• W4210604509 cites W2009408704 @default.
• W4210604509 cites W2032643752 @default.
• W4210604509 cites W2038419555 @default.
• W4210604509 cites W2040231435 @default.
• W4210604509 cites W2054929374 @default.
• W4210604509 cites W2060319077 @default.
• W4210604509 cites W2069885465 @default.
• W4210604509 cites W2079313884 @default.
• W4210604509 cites W2084566588 @default.
• W4210604509 cites W2089915293 @default.
• W4210604509 cites W2117671988 @default.
• W4210604509 cites W2124030567 @default.
• W4210604509 cites W2124478244 @default.
• W4210604509 cites W2141706699 @default.
• W4210604509 cites W2154780300 @default.
• W4210604509 cites W2157816812 @default.
• W4210604509 cites W2196268942 @default.
• W4210604509 cites W2219920450 @default.
• W4210604509 cites W2238698772 @default.
• W4210604509 cites W2276853091 @default.
• W4210604509 cites W2298406751 @default.
• W4210604509 cites W2337557746 @default.
• W4210604509 cites W2343157050 @default.
• W4210604509 cites W2395225545 @default.
• W4210604509 cites W2473313434 @default.
• W4210604509 cites W2529649944 @default.
• W4210604509 cites W2545175005 @default.
• W4210604509 cites W2593787260 @default.
• W4210604509 cites W2601400544 @default.
• W4210604509 cites W2602908130 @default.
• W4210604509 cites W2700330585 @default.
• W4210604509 cites W2738888781 @default.
• W4210604509 cites W2750990748 @default.
• W4210604509 cites W2791135917 @default.
• W4210604509 cites W2801227284 @default.
• W4210604509 cites W2801244110 @default.
• W4210604509 cites W2804560798 @default.
• W4210604509 cites W2849227165 @default.
• W4210604509 cites W2885376240 @default.
• W4210604509 cites W2888048543 @default.
• W4210604509 cites W2903032912 @default.
• W4210604509 cites W2908417137 @default.
• W4210604509 cites W2919600844 @default.
• W4210604509 cites W2938743978 @default.
• W4210604509 cites W3038832112 @default.
• W4210604509 cites W3042129895 @default.
• W4210604509 cites W3047418547 @default.
• W4210604509 cites W3097014139 @default.
• W4210604509 cites W3113897986 @default.
• W4210604509 cites W3127432357 @default.
• W4210604509 cites W3132240972 @default.
• W4210604509 cites W3153473731 @default.
• W4210604509 cites W3181451168 @default.
• W4210604509 cites W4239346618 @default.
• W4210604509 doi "https://doi.org/10.2967/jnumed.121.263254" @default.
• W4210604509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35086898" @default.
• W4210604509 hasPublicationYear "2022" @default.
• W4210604509 type Work @default.
• W4210604509 citedByCount "23" @default.
• W4210604509 countsByYear W42106045092022 @default.
• W4210604509 countsByYear W42106045092023 @default.
• W4210604509 crossrefType "journal-article" @default.
• W4210604509 hasAuthorship W4210604509A5000636220 @default.
• W4210604509 hasAuthorship W4210604509A5000945121 @default.
• W4210604509 hasAuthorship W4210604509A5008078105 @default.
• W4210604509 hasAuthorship W4210604509A5017027985 @default.
• W4210604509 hasAuthorship W4210604509A5022818431 @default.
• W4210604509 hasAuthorship W4210604509A5028540036 @default.
• W4210604509 hasAuthorship W4210604509A5035847289 @default.
• W4210604509 hasAuthorship W4210604509A5058052951 @default.
• W4210604509 hasAuthorship W4210604509A5063415107 @default.

• next