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- W4210607884 abstract "Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected intravenously with a lethal dose of lymphocytic choriomeningitis virus (LCMV) provide a model for Lassa virus infection of humans. Blood samples taken before and during the course of infection were used to monitor gene expression changes that paralleled disease onset. Changes in blood showed major disruptions in eicosanoid, immune response, and hormone response pathways. Approximately 12% of host genes alter their expression after LCMV infection, and a subset of these genes can discriminate between virulent and non-virulent LCMV infection. Major transcription changes have been given preliminary confirmation by quantitative PCR and protein studies and will be valuable candidates for future validation as biomarkers for arenavirus disease. PMID: 17522210 Funding information This work was supported by: NIAID NIH HHS, United States Grant ID: U54 AI057168 NIAID NIH HHS, United States Grant ID: AI053620 NIAID NIH HHS, United States Grant ID: AI053619" @default.
- W4210607884 created "2022-02-08" @default.
- W4210607884 creator A5022547631 @default.
- W4210607884 date "2007-07-13" @default.
- W4210607884 modified "2023-10-16" @default.
- W4210607884 title "Faculty Opinions recommendation of Early blood profiles of virus infection in a monkey model for Lassa fever." @default.
- W4210607884 doi "https://doi.org/10.3410/f.1088799.541900" @default.
- W4210607884 hasPublicationYear "2007" @default.
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