FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210608488> ?p ?o ?g. }

• W4210608488 abstract "The meniscus is composed of an avascular inner region and vascular outer region. The vascular region has been shown to contain a progenitor population with multilineage differentiation capacity. Strategies facilitating the isolation and propagation of these progenitors can be used to develop cell-based meniscal therapies. Differential adhesion to fibronectin has been used to isolate progenitor populations from cartilage, while low oxygen or physioxia (2% oxygen) enhances the meniscal phenotype. This study aimed to isolate progenitor populations from the avascular and vascular meniscus using differential fibronectin adherence and examine their clonogenicity and differentiation potential under hyperoxia (20% oxygen) and physioxia (2% oxygen). Human vascular and avascular meniscus cells were seeded onto fibronectin-coated dishes for a short period and monitored for colony formation under either hyperoxia or physioxia. Non-fibronectin adherent meniscus cells were also expanded under both oxygen tension. Individual fibronectin adherent colonies were isolated and further expanded, until approximately ten population doublings (passage 3), whereby they underwent chondrogenic, osteogenic, and adipogenic differentiation. Physioxia enhances clonogenicity of vascular and avascular meniscus cells on plastic or fibronectin-coated plates. Combined differential fibronectin adhesion and physioxia isolated a progenitor population from both meniscus regions with trilineage differentiation potential compared to equivalent hyperoxia progenitors. Physioxia isolated progenitors had a significantly enhanced meniscus matrix content without the presence of collagen X. These results demonstrate that combined physioxia and fibronectin adherence can isolate and propagate a meniscus progenitor population that can potentially be used to treat meniscal tears or defects." @default.
• W4210608488 created "2022-02-08" @default.
• W4210608488 creator A5004120668 @default.
• W4210608488 creator A5013603415 @default.
• W4210608488 creator A5020696770 @default.
• W4210608488 creator A5023195260 @default.
• W4210608488 creator A5043373201 @default.
• W4210608488 creator A5052872170 @default.
• W4210608488 creator A5056229143 @default.
• W4210608488 creator A5060488736 @default.
• W4210608488 creator A5085719741 @default.
• W4210608488 date "2022-01-28" @default.
• W4210608488 modified "2023-10-01" @default.
• W4210608488 title "Fibronectin Adherent Cell Populations Derived From Avascular and Vascular Regions of the Meniscus Have Enhanced Clonogenicity and Differentiation Potential Under Physioxia" @default.
• W4210608488 cites W1545655893 @default.
• W4210608488 cites W191978794 @default.
• W4210608488 cites W1966536689 @default.
• W4210608488 cites W1974981056 @default.
• W4210608488 cites W1982628350 @default.
• W4210608488 cites W1982862608 @default.
• W4210608488 cites W1988357840 @default.
• W4210608488 cites W2003328208 @default.
• W4210608488 cites W2011940076 @default.
• W4210608488 cites W2019051273 @default.
• W4210608488 cites W2029675195 @default.
• W4210608488 cites W2030138474 @default.
• W4210608488 cites W2044322920 @default.
• W4210608488 cites W2067716147 @default.
• W4210608488 cites W2069038552 @default.
• W4210608488 cites W2074048048 @default.
• W4210608488 cites W2076491580 @default.
• W4210608488 cites W2082712298 @default.
• W4210608488 cites W2089797785 @default.
• W4210608488 cites W2108434819 @default.
• W4210608488 cites W2118622683 @default.
• W4210608488 cites W2138050858 @default.
• W4210608488 cites W2140013481 @default.
• W4210608488 cites W2155712212 @default.
• W4210608488 cites W2161915238 @default.
• W4210608488 cites W2170361814 @default.
• W4210608488 cites W2171308010 @default.
• W4210608488 cites W2221907636 @default.
• W4210608488 cites W2280163212 @default.
• W4210608488 cites W2310491900 @default.
• W4210608488 cites W2316811133 @default.
• W4210608488 cites W2336710554 @default.
• W4210608488 cites W2507767792 @default.
• W4210608488 cites W2538112709 @default.
• W4210608488 cites W2547241940 @default.
• W4210608488 cites W2565899049 @default.
• W4210608488 cites W2591511172 @default.
• W4210608488 cites W2754591136 @default.
• W4210608488 cites W2763224399 @default.
• W4210608488 cites W2770108509 @default.
• W4210608488 cites W2888115383 @default.
• W4210608488 cites W2911791019 @default.
• W4210608488 cites W2919178738 @default.
• W4210608488 cites W2957619314 @default.
• W4210608488 cites W2964408339 @default.
• W4210608488 cites W2969307549 @default.
• W4210608488 cites W2993241761 @default.
• W4210608488 cites W2995891523 @default.
• W4210608488 cites W3049446219 @default.
• W4210608488 cites W3087874567 @default.
• W4210608488 cites W3135801977 @default.
• W4210608488 cites W3152161230 @default.
• W4210608488 cites W3164897339 @default.
• W4210608488 cites W3187815548 @default.
• W4210608488 doi "https://doi.org/10.3389/fbioe.2021.789621" @default.
• W4210608488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35155405" @default.
• W4210608488 hasPublicationYear "2022" @default.
• W4210608488 type Work @default.
• W4210608488 citedByCount "3" @default.
• W4210608488 countsByYear W42106084882022 @default.
• W4210608488 countsByYear W42106084882023 @default.
• W4210608488 crossrefType "journal-article" @default.
• W4210608488 hasAuthorship W4210608488A5004120668 @default.
• W4210608488 hasAuthorship W4210608488A5013603415 @default.
• W4210608488 hasAuthorship W4210608488A5020696770 @default.
• W4210608488 hasAuthorship W4210608488A5023195260 @default.
• W4210608488 hasAuthorship W4210608488A5043373201 @default.
• W4210608488 hasAuthorship W4210608488A5052872170 @default.
• W4210608488 hasAuthorship W4210608488A5056229143 @default.
• W4210608488 hasAuthorship W4210608488A5060488736 @default.
• W4210608488 hasAuthorship W4210608488A5085719741 @default.
• W4210608488 hasBestOaLocation W42106084881 @default.
• W4210608488 hasConcept C105702510 @default.
• W4210608488 hasConcept C120665830 @default.
• W4210608488 hasConcept C121332964 @default.
• W4210608488 hasConcept C178790620 @default.
• W4210608488 hasConcept C185592680 @default.
• W4210608488 hasConcept C189165786 @default.
• W4210608488 hasConcept C189178095 @default.
• W4210608488 hasConcept C201750760 @default.
• W4210608488 hasConcept C203014093 @default.
• W4210608488 hasConcept C2780550940 @default.
• W4210608488 hasConcept C2780672939 @default.
• W4210608488 hasConcept C28328180 @default.
• W4210608488 hasConcept C2908647359 @default.
• W4210608488 hasConcept C540031477 @default.

• next