Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210610401> ?p ?o ?g. }
- W4210610401 endingPage "675" @default.
- W4210610401 startingPage "675" @default.
- W4210610401 abstract "Antiphospholipid syndrome is an autoimmune disorder characterized by vascular thrombosis and/or pregnancy morbidity associated with persistent antiphospholipid antibody positivity. Cases fulfilling the Sydney criteria for obstetric morbidity with no previous thrombosis are known as obstetric antiphospholipid syndrome (OAPS). OAPS is the most identified cause of recurrent pregnancy loss and late-pregnancy morbidity related to placental injury. Cases with incomplete clinical or laboratory data are classified as obstetric morbidity APS (OMAPS) and non-criteria OAPS (NC-OAPS), respectively. Inflammatory and thrombotic mechanisms are involved in the pathophysiology of OAPS. Trophoblasts, endothelium, platelets and innate immune cells are key cellular players. Complement activation plays a crucial pathogenic role. Secondary placental thrombosis appears by clot formation in response to tissue factor activation. New risk assessment tools could improve the prediction of obstetric complication recurrences or thromboses. The standard-of-care treatment consists of low-dose aspirin and prophylactic low molecular weight heparin. In refractory cases, the addition of hydroxychloroquine, low-dose prednisone or IVIG improve pregnancy outcomes. Statins and eculizumab are currently being tested for treating selected OAPS women. Finally, we revisited recent insights and concerns about the pathophysiology, diagnosis and management of OAPS." @default.
- W4210610401 created "2022-02-08" @default.
- W4210610401 creator A5025542652 @default.
- W4210610401 creator A5043607476 @default.
- W4210610401 creator A5052707084 @default.
- W4210610401 creator A5059676292 @default.
- W4210610401 creator A5067041568 @default.
- W4210610401 creator A5084217807 @default.
- W4210610401 date "2022-01-28" @default.
- W4210610401 modified "2023-10-18" @default.
- W4210610401 title "Pathogenesis, Diagnosis and Management of Obstetric Antiphospholipid Syndrome: A Comprehensive Review" @default.
- W4210610401 cites W1492769522 @default.
- W4210610401 cites W1521045812 @default.
- W4210610401 cites W1554060460 @default.
- W4210610401 cites W1578529971 @default.
- W4210610401 cites W1780873094 @default.
- W4210610401 cites W1820213619 @default.
- W4210610401 cites W1880474234 @default.
- W4210610401 cites W1897094044 @default.
- W4210610401 cites W1922557247 @default.
- W4210610401 cites W1939960775 @default.
- W4210610401 cites W1963494811 @default.
- W4210610401 cites W1967516704 @default.
- W4210610401 cites W1971076479 @default.
- W4210610401 cites W1974175515 @default.
- W4210610401 cites W1975493430 @default.
- W4210610401 cites W1977946624 @default.
- W4210610401 cites W1979469841 @default.
- W4210610401 cites W1979599639 @default.
- W4210610401 cites W1982511037 @default.
- W4210610401 cites W1982745955 @default.
- W4210610401 cites W1982786699 @default.
- W4210610401 cites W1983166037 @default.
- W4210610401 cites W1983823516 @default.
- W4210610401 cites W1990291647 @default.
- W4210610401 cites W1992525889 @default.
- W4210610401 cites W1992631495 @default.
- W4210610401 cites W1993188608 @default.
- W4210610401 cites W1994238439 @default.
- W4210610401 cites W1996377128 @default.
- W4210610401 cites W2001976130 @default.
- W4210610401 cites W2004888846 @default.
- W4210610401 cites W2007180422 @default.
- W4210610401 cites W2008273918 @default.
- W4210610401 cites W2015250939 @default.
- W4210610401 cites W2015256503 @default.
- W4210610401 cites W2015878170 @default.
- W4210610401 cites W2016550449 @default.
- W4210610401 cites W2016642143 @default.
- W4210610401 cites W2017344177 @default.
- W4210610401 cites W2019685037 @default.
- W4210610401 cites W2020469940 @default.
- W4210610401 cites W2023880291 @default.
- W4210610401 cites W2027166087 @default.
- W4210610401 cites W2027956144 @default.
- W4210610401 cites W2030992311 @default.
- W4210610401 cites W2032470152 @default.
- W4210610401 cites W2032787666 @default.
- W4210610401 cites W2033560033 @default.
- W4210610401 cites W2036371614 @default.
- W4210610401 cites W2037917671 @default.
- W4210610401 cites W2038069098 @default.
- W4210610401 cites W2038699236 @default.
- W4210610401 cites W2038885399 @default.
- W4210610401 cites W2039200195 @default.
- W4210610401 cites W2039454583 @default.
- W4210610401 cites W2039918852 @default.
- W4210610401 cites W2040532865 @default.
- W4210610401 cites W2042958596 @default.
- W4210610401 cites W2044707852 @default.
- W4210610401 cites W2044922497 @default.
- W4210610401 cites W2049326681 @default.
- W4210610401 cites W2049946512 @default.
- W4210610401 cites W2050158555 @default.
- W4210610401 cites W2051506906 @default.
- W4210610401 cites W2054330426 @default.
- W4210610401 cites W2056493351 @default.
- W4210610401 cites W2056792031 @default.
- W4210610401 cites W2059495478 @default.
- W4210610401 cites W2060422033 @default.
- W4210610401 cites W2060759027 @default.
- W4210610401 cites W2063956854 @default.
- W4210610401 cites W2064568183 @default.
- W4210610401 cites W2069540608 @default.
- W4210610401 cites W2069797332 @default.
- W4210610401 cites W2073645312 @default.
- W4210610401 cites W2075491158 @default.
- W4210610401 cites W2080659789 @default.
- W4210610401 cites W2081149712 @default.
- W4210610401 cites W2081684310 @default.
- W4210610401 cites W2081942726 @default.
- W4210610401 cites W2091117299 @default.
- W4210610401 cites W2091470702 @default.
- W4210610401 cites W2092426441 @default.
- W4210610401 cites W2097046783 @default.
- W4210610401 cites W2098005560 @default.
- W4210610401 cites W2098261358 @default.
- W4210610401 cites W2098834735 @default.