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- W4210611412 abstract "Cadmium (Cd) exerts detrimental effects on multiple biological processes of the living organisms along with epigenetic transgenerational effect. Drosophila melanogaster offers unique opportunity to evaluate Cd toxicity when studying important life traits in short duration of time by designing distinct behavioural assays. Present study utilized this model organism to assess Cd induced lethality, retarded growth, decreased life span and altered behaviour of the animals either at larval or adult stage. Our investigations revealed reduced locomotion and reproductive fitness of the animals upon Cd exposure. Transgenerational effect on locomotion was found to be behaviour specific as larval crawling was affected, but adult fly negative geotaxis was comparable to the control. Mechanistically, decreased antioxidant enzymes activity, superoxide dismutase (SOD) and catalase (CAT) together with altered homeostasis of essential elements (Fe, Zn and Mg) may be responsible for the observed effects. Altogether our work showed extensive range of Cd altered Drosophila behaviour which warrants need to control environmental Cd toxicity." @default.
- W4210611412 created "2022-02-08" @default.
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- W4210611412 date "2022-05-01" @default.
- W4210611412 modified "2023-09-26" @default.
- W4210611412 title "Dietary cadmium induced declined locomotory and reproductive fitness with altered homeostasis of essential elements in Drosophila melanogaster" @default.
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- W4210611412 doi "https://doi.org/10.1016/j.cbpc.2022.109289" @default.
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