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- W4210611935 abstract "Hypertension (HTN) and chronic kidney disease (CKD) are common in ageing cats. In humans, blood pressure (BP) and renal function are complex heritable traits. We performed the first feline genome-wide association study (GWAS) of quantitative traits systolic BP and creatinine and binary outcomes HTN and CKD, testing 1022 domestic cats with a discovery, replication and meta-analysis design. No variants reached experimental significance level in the discovery stage for any phenotype. Follow up of the top 9 variants for creatinine and 5 for systolic BP, one SNP reached experimental-wide significance for association with creatinine in the combined meta-analysis (chrD1.10258177; P = 1.34 × 10-6). Exploratory genetic risk score (GRS) analyses were performed. Within the discovery sample, GRS of top SNPs from the BP and creatinine GWAS show strong association with HTN and CKD but did not validate in independent replication samples. A GRS including SNPs corresponding to human CKD genes was not significant in an independent subset of cats. Gene-set enrichment and pathway-based analysis (GSEA) was performed for both quantitative phenotypes, with 30 enriched pathways with creatinine. Our results support the utility of GWASs and GSEA for genetic discovery of complex traits in cats, with the caveat of our findings requiring validation." @default.
- W4210611935 created "2022-02-08" @default.
- W4210611935 creator A5009315136 @default.
- W4210611935 creator A5012110797 @default.
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- W4210611935 creator A5025847076 @default.
- W4210611935 creator A5062854708 @default.
- W4210611935 creator A5078023429 @default.
- W4210611935 date "2022-02-03" @default.
- W4210611935 modified "2023-09-26" @default.
- W4210611935 title "First genome-wide association study investigating blood pressure and renal traits in domestic cats" @default.
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