FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210613650> ?p ?o ?g. }

• W4210613650 endingPage "e053304" @default.
• W4210613650 startingPage "e053304" @default.
• W4210613650 abstract "Alzheimer's disease is the most prevalent type dementia and has a strong genetic component. Much of AD genomic research has focused on identifying risk variants, primarily in European ancestry populations. After immigration to the United States, the Amish experienced a genetic bottleneck, making it likely that their underlying genetic architecture is different from the broader European ancestry population. Here, we compare the genetic risk for Alzheimer's disease in an Amish and general European ancestry population using genetic risk scores (GRSs).1,981 adults were recruited from Amish communities in Indiana and Ohio. A non-Amish population of 2,470 adults were recruited from clinics in Tennessee, North Carolina, and Florida as a comparison group. Subjects were screened for cognitive impairment and further evaluated for AD and dementia. Genotype data were collected using Illumina genotyping chips. Imputation was performed based on a 1,000 Genomes reference panel. GRSs were generated using genome-wide significant variants from Kunkle et al., (2019), weighted by their log-odds ratios. We compared the GRSs by source population and case status. Further, we evaluated their predictive ability on AD status with and without sex, age, and APOE genotype covariates.The results indicated that there exists less variation in GRSs among the Amish population. This is evident in how the four highest GRSs belonged to non-Amish individuals. The median GRS of Amish cases was also moderately lower overall among Amish cases (0.0163) compared to non-Amish cases (0.0171). In the Amish population, area under curve (AUC) of the GRS model was strengthened considerably from 0.541 to 0.872 by inclusion of the sex and age covariates and slightly (AUC=0.883) by further inclusion of APOE genotype. In the non-Amish group, inclusion of sex and age improved AUC from 0.583 to 0.697 and to 0.817 by subsequent inclusion of APOE genotype.These results suggest that the Amish have a different genetic architecture than a general European-ancestry population, manifesting itself in less overall variation but also a lower relative importance of APOE. Since the prevalence of dementia in the Amish is similar to the general European population, this suggests the Amish may harbor unique AD genetic risk variants." @default.
• W4210613650 created "2022-02-08" @default.
• W4210613650 creator A5007357271 @default.
• W4210613650 creator A5008196495 @default.
• W4210613650 creator A5020266650 @default.
• W4210613650 creator A5021262540 @default.
• W4210613650 creator A5025328133 @default.
• W4210613650 creator A5030374844 @default.
• W4210613650 creator A5034664934 @default.
• W4210613650 creator A5038676225 @default.
• W4210613650 creator A5039221620 @default.
• W4210613650 creator A5039717261 @default.
• W4210613650 creator A5049976794 @default.
• W4210613650 creator A5050863975 @default.
• W4210613650 creator A5057611574 @default.
• W4210613650 creator A5062686238 @default.
• W4210613650 creator A5062996292 @default.
• W4210613650 creator A5063659153 @default.
• W4210613650 creator A5066783581 @default.
• W4210613650 creator A5069324665 @default.
• W4210613650 creator A5071060728 @default.
• W4210613650 creator A5071820702 @default.
• W4210613650 creator A5071977840 @default.
• W4210613650 creator A5087905863 @default.
• W4210613650 creator A5089104364 @default.
• W4210613650 creator A5089289757 @default.
• W4210613650 date "2021-12-01" @default.
• W4210613650 modified "2023-09-27" @default.
• W4210613650 title "Genetic risk score for Alzheimer's disease in the Amish highlights differences in the genetic architecture compared to other European ancestry populations." @default.
• W4210613650 doi "https://doi.org/10.1002/alz.053304" @default.
• W4210613650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35109012" @default.
• W4210613650 hasPublicationYear "2021" @default.
• W4210613650 type Work @default.
• W4210613650 citedByCount "0" @default.
• W4210613650 crossrefType "journal-article" @default.
• W4210613650 hasAuthorship W4210613650A5007357271 @default.
• W4210613650 hasAuthorship W4210613650A5008196495 @default.
• W4210613650 hasAuthorship W4210613650A5020266650 @default.
• W4210613650 hasAuthorship W4210613650A5021262540 @default.
• W4210613650 hasAuthorship W4210613650A5025328133 @default.
• W4210613650 hasAuthorship W4210613650A5030374844 @default.
• W4210613650 hasAuthorship W4210613650A5034664934 @default.
• W4210613650 hasAuthorship W4210613650A5038676225 @default.
• W4210613650 hasAuthorship W4210613650A5039221620 @default.
• W4210613650 hasAuthorship W4210613650A5039717261 @default.
• W4210613650 hasAuthorship W4210613650A5049976794 @default.
• W4210613650 hasAuthorship W4210613650A5050863975 @default.
• W4210613650 hasAuthorship W4210613650A5057611574 @default.
• W4210613650 hasAuthorship W4210613650A5062686238 @default.
• W4210613650 hasAuthorship W4210613650A5062996292 @default.
• W4210613650 hasAuthorship W4210613650A5063659153 @default.
• W4210613650 hasAuthorship W4210613650A5066783581 @default.
• W4210613650 hasAuthorship W4210613650A5069324665 @default.
• W4210613650 hasAuthorship W4210613650A5071060728 @default.
• W4210613650 hasAuthorship W4210613650A5071820702 @default.
• W4210613650 hasAuthorship W4210613650A5071977840 @default.
• W4210613650 hasAuthorship W4210613650A5087905863 @default.
• W4210613650 hasAuthorship W4210613650A5089104364 @default.
• W4210613650 hasAuthorship W4210613650A5089289757 @default.
• W4210613650 hasConcept C104317684 @default.
• W4210613650 hasConcept C106208931 @default.
• W4210613650 hasConcept C119857082 @default.
• W4210613650 hasConcept C126322002 @default.
• W4210613650 hasConcept C135763542 @default.
• W4210613650 hasConcept C144024400 @default.
• W4210613650 hasConcept C149923435 @default.
• W4210613650 hasConcept C153209595 @default.
• W4210613650 hasConcept C2779134260 @default.
• W4210613650 hasConcept C2779483572 @default.
• W4210613650 hasConcept C2908647359 @default.
• W4210613650 hasConcept C31467283 @default.
• W4210613650 hasConcept C41008148 @default.
• W4210613650 hasConcept C54355233 @default.
• W4210613650 hasConcept C58041806 @default.
• W4210613650 hasConcept C68873052 @default.
• W4210613650 hasConcept C71924100 @default.
• W4210613650 hasConcept C74909509 @default.
• W4210613650 hasConcept C75069973 @default.
• W4210613650 hasConcept C81941488 @default.
• W4210613650 hasConcept C86803240 @default.
• W4210613650 hasConcept C9287583 @default.
• W4210613650 hasConcept C9357733 @default.
• W4210613650 hasConceptScore W4210613650C104317684 @default.
• W4210613650 hasConceptScore W4210613650C106208931 @default.
• W4210613650 hasConceptScore W4210613650C119857082 @default.
• W4210613650 hasConceptScore W4210613650C126322002 @default.
• W4210613650 hasConceptScore W4210613650C135763542 @default.
• W4210613650 hasConceptScore W4210613650C144024400 @default.
• W4210613650 hasConceptScore W4210613650C149923435 @default.
• W4210613650 hasConceptScore W4210613650C153209595 @default.
• W4210613650 hasConceptScore W4210613650C2779134260 @default.
• W4210613650 hasConceptScore W4210613650C2779483572 @default.
• W4210613650 hasConceptScore W4210613650C2908647359 @default.
• W4210613650 hasConceptScore W4210613650C31467283 @default.
• W4210613650 hasConceptScore W4210613650C41008148 @default.
• W4210613650 hasConceptScore W4210613650C54355233 @default.
• W4210613650 hasConceptScore W4210613650C58041806 @default.
• W4210613650 hasConceptScore W4210613650C68873052 @default.

• next