Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210630160> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4210630160 endingPage "5" @default.
- W4210630160 startingPage "5" @default.
- W4210630160 abstract "Tuberculosis (TB) is a global health burden especially in tropical countries. Extensive increments in MDR (Multidrug resistance (MDR): Resistance to at least both isoniazid and rifampicin.) and XDR (Extensive drug resistance (XDR): Resistance to any fluoroquinolone, and at least one of three second-line injectable drugs (capreomycin, kanamycin, and amikacin), in addition to multidrug resistance) tuberculosis highlights the ineffectiveness of established anti-TB agents. There is an urgent necessity to identify potent anti-TB agents with unique mechanisms. Green tea and Black tea polyphenols have great potential to inhibit viruses including SARS-COV-2, bacterial strains, etc. In this context, we have screened and identified 65 Green tea bioactive compounds against four mycobacterial pantothenate synthetase and enoyl acyl carrier enzymes. Our molecular docking results revealed that Theaflavin-3-gallate had a higher binding affinity against 2X22 and 3IVX targets with docking scores of −134.13 and −135.592 Kcal/mol, respectively. Furthermore, our molecular dynamics simulations for 10 ns resulted better stabilities of these complexes. We also evaluated in silico drug-likeness and toxicity profiles for the studied polyphenols. Our in silico toxicity analysis suggested that these polyphenols would exhibit lesser toxicity such as eye corrosion, skin irritations, etc. Thus, our present study would provide better insights on studying naturally occurring polyphenols as potential anti-TB agents." @default.
- W4210630160 created "2022-02-08" @default.
- W4210630160 creator A5007487916 @default.
- W4210630160 creator A5026890396 @default.
- W4210630160 date "2021-08-31" @default.
- W4210630160 modified "2023-09-25" @default.
- W4210630160 title "Naturally Occurring Green Tea Polyphenols as Anti-Mycobacterial Agents" @default.
- W4210630160 cites W1979702128 @default.
- W4210630160 cites W2023857477 @default.
- W4210630160 cites W2075000963 @default.
- W4210630160 cites W2152233061 @default.
- W4210630160 cites W2766345689 @default.
- W4210630160 cites W2897236024 @default.
- W4210630160 cites W3025917451 @default.
- W4210630160 cites W3143941394 @default.
- W4210630160 cites W3176506019 @default.
- W4210630160 cites W4207070825 @default.
- W4210630160 doi "https://doi.org/10.3390/ecms2021-10844" @default.
- W4210630160 hasPublicationYear "2021" @default.
- W4210630160 type Work @default.
- W4210630160 citedByCount "0" @default.
- W4210630160 crossrefType "journal-article" @default.
- W4210630160 hasAuthorship W4210630160A5007487916 @default.
- W4210630160 hasAuthorship W4210630160A5026890396 @default.
- W4210630160 hasBestOaLocation W42106301601 @default.
- W4210630160 hasConcept C104317684 @default.
- W4210630160 hasConcept C114851261 @default.
- W4210630160 hasConcept C133936738 @default.
- W4210630160 hasConcept C151730666 @default.
- W4210630160 hasConcept C185592680 @default.
- W4210630160 hasConcept C2775905019 @default.
- W4210630160 hasConcept C2776228421 @default.
- W4210630160 hasConcept C2777107064 @default.
- W4210630160 hasConcept C2778004101 @default.
- W4210630160 hasConcept C2778607973 @default.
- W4210630160 hasConcept C2779343474 @default.
- W4210630160 hasConcept C2780487065 @default.
- W4210630160 hasConcept C2781019175 @default.
- W4210630160 hasConcept C41685203 @default.
- W4210630160 hasConcept C42972112 @default.
- W4210630160 hasConcept C501593827 @default.
- W4210630160 hasConcept C55493867 @default.
- W4210630160 hasConcept C556039675 @default.
- W4210630160 hasConcept C70899900 @default.
- W4210630160 hasConcept C71924100 @default.
- W4210630160 hasConcept C86803240 @default.
- W4210630160 hasConcept C89423630 @default.
- W4210630160 hasConcept C98274493 @default.
- W4210630160 hasConceptScore W4210630160C104317684 @default.
- W4210630160 hasConceptScore W4210630160C114851261 @default.
- W4210630160 hasConceptScore W4210630160C133936738 @default.
- W4210630160 hasConceptScore W4210630160C151730666 @default.
- W4210630160 hasConceptScore W4210630160C185592680 @default.
- W4210630160 hasConceptScore W4210630160C2775905019 @default.
- W4210630160 hasConceptScore W4210630160C2776228421 @default.
- W4210630160 hasConceptScore W4210630160C2777107064 @default.
- W4210630160 hasConceptScore W4210630160C2778004101 @default.
- W4210630160 hasConceptScore W4210630160C2778607973 @default.
- W4210630160 hasConceptScore W4210630160C2779343474 @default.
- W4210630160 hasConceptScore W4210630160C2780487065 @default.
- W4210630160 hasConceptScore W4210630160C2781019175 @default.
- W4210630160 hasConceptScore W4210630160C41685203 @default.
- W4210630160 hasConceptScore W4210630160C42972112 @default.
- W4210630160 hasConceptScore W4210630160C501593827 @default.
- W4210630160 hasConceptScore W4210630160C55493867 @default.
- W4210630160 hasConceptScore W4210630160C556039675 @default.
- W4210630160 hasConceptScore W4210630160C70899900 @default.
- W4210630160 hasConceptScore W4210630160C71924100 @default.
- W4210630160 hasConceptScore W4210630160C86803240 @default.
- W4210630160 hasConceptScore W4210630160C89423630 @default.
- W4210630160 hasConceptScore W4210630160C98274493 @default.
- W4210630160 hasIssue "1" @default.
- W4210630160 hasLocation W42106301601 @default.
- W4210630160 hasOpenAccess W4210630160 @default.
- W4210630160 hasPrimaryLocation W42106301601 @default.
- W4210630160 hasRelatedWork W2065465688 @default.
- W4210630160 hasRelatedWork W2126924258 @default.
- W4210630160 hasRelatedWork W2170164957 @default.
- W4210630160 hasRelatedWork W2471509732 @default.
- W4210630160 hasRelatedWork W2580148861 @default.
- W4210630160 hasRelatedWork W2796780576 @default.
- W4210630160 hasRelatedWork W3185139970 @default.
- W4210630160 hasRelatedWork W4308478860 @default.
- W4210630160 hasRelatedWork W4315782182 @default.
- W4210630160 hasRelatedWork W2741914730 @default.
- W4210630160 hasVolume "7" @default.
- W4210630160 isParatext "false" @default.
- W4210630160 isRetracted "false" @default.
- W4210630160 workType "article" @default.