Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210630725> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4210630725 endingPage "26" @default.
- W4210630725 startingPage "16" @default.
- W4210630725 abstract "The research aims to identify the inhibitory potential of natural dietary phytochemicals against non-insulinotropic target protein alpha-glucosidase and its possible implications to diabetes mellitus type 2. A data set of sixteen plant-derived dietary molecules viz., 4,5-dimethyl-3-hydroxy-2(5H)-furanone, apigenin, bromelain, caffeic acid, cholecalciferol, dihydrokaempferol 7-o-glucopyranoside, galactomannan, genkwanin, isoimperatorin, luteolin, luteolin 7-o-glucoside, neohesperidin, oleanoic acid, pelargonidin-3-rutinoside, quercetin, and quinic acid were taken to accomplish molecular docking succeeded by their comparison with known inhibitors including acarbose, miglitol, voglibose, emiglitate, and 1-deoxynojirimycin. Among all phyto-compounds, bromelain (ΔG: -9.54 kcal/mol), cholecalciferol (-8.47 kcal/mol), luteolin (-9.02 kcal/mol), and neohesperidin (-8.53 kcal/mol) demonstrated better binding interactions with alpha-glucosidase in comparison to the best-known inhibitor, acarbose (ΔG: -7.93 kcal/mol). Molecular dynamics simulation of 10 ns duration, CYP450 site of metabolism identification, and prediction of activity spectra for substances depicted the bromelain as the most stable inhibitor compared to luteolin and acarbose. Findings of molecular interactions, molecular dynamics study, metabolism, and biological activity prediction proved bromelain as a potential alpha-glucosidase inhibitor. Thus, bromelain might be helpful as an insulin-independent therapeutic molecule towards controlling and managing diabetes mellitus type 2." @default.
- W4210630725 created "2022-02-08" @default.
- W4210630725 creator A5000657460 @default.
- W4210630725 creator A5006658273 @default.
- W4210630725 creator A5028401917 @default.
- W4210630725 creator A5029848805 @default.
- W4210630725 creator A5031370016 @default.
- W4210630725 creator A5032867333 @default.
- W4210630725 creator A5044019757 @default.
- W4210630725 creator A5065361591 @default.
- W4210630725 creator A5066748035 @default.
- W4210630725 creator A5082827813 @default.
- W4210630725 creator A5086912937 @default.
- W4210630725 date "2022-02-04" @default.
- W4210630725 modified "2023-10-01" @default.
- W4210630725 title "Identifying the alpha-glucosidase inhibitory potential of dietary phytochemicals against diabetes mellitus type 2 via molecular interactions and dynamics simulation" @default.
- W4210630725 doi "https://doi.org/10.14715/cmb/2021.67.5.3" @default.
- W4210630725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35818276" @default.
- W4210630725 hasPublicationYear "2022" @default.
- W4210630725 type Work @default.
- W4210630725 citedByCount "3" @default.
- W4210630725 countsByYear W42106307252023 @default.
- W4210630725 crossrefType "journal-article" @default.
- W4210630725 hasAuthorship W4210630725A5000657460 @default.
- W4210630725 hasAuthorship W4210630725A5006658273 @default.
- W4210630725 hasAuthorship W4210630725A5028401917 @default.
- W4210630725 hasAuthorship W4210630725A5029848805 @default.
- W4210630725 hasAuthorship W4210630725A5031370016 @default.
- W4210630725 hasAuthorship W4210630725A5032867333 @default.
- W4210630725 hasAuthorship W4210630725A5044019757 @default.
- W4210630725 hasAuthorship W4210630725A5065361591 @default.
- W4210630725 hasAuthorship W4210630725A5066748035 @default.
- W4210630725 hasAuthorship W4210630725A5082827813 @default.
- W4210630725 hasAuthorship W4210630725A5086912937 @default.
- W4210630725 hasBestOaLocation W42106307251 @default.
- W4210630725 hasConcept C126322002 @default.
- W4210630725 hasConcept C181199279 @default.
- W4210630725 hasConcept C185592680 @default.
- W4210630725 hasConcept C2776080593 @default.
- W4210630725 hasConcept C2776617576 @default.
- W4210630725 hasConcept C2777832050 @default.
- W4210630725 hasConcept C2778004101 @default.
- W4210630725 hasConcept C2778199505 @default.
- W4210630725 hasConcept C2778609962 @default.
- W4210630725 hasConcept C2779054382 @default.
- W4210630725 hasConcept C2779306644 @default.
- W4210630725 hasConcept C55493867 @default.
- W4210630725 hasConcept C71240020 @default.
- W4210630725 hasConcept C71924100 @default.
- W4210630725 hasConcept C98274493 @default.
- W4210630725 hasConceptScore W4210630725C126322002 @default.
- W4210630725 hasConceptScore W4210630725C181199279 @default.
- W4210630725 hasConceptScore W4210630725C185592680 @default.
- W4210630725 hasConceptScore W4210630725C2776080593 @default.
- W4210630725 hasConceptScore W4210630725C2776617576 @default.
- W4210630725 hasConceptScore W4210630725C2777832050 @default.
- W4210630725 hasConceptScore W4210630725C2778004101 @default.
- W4210630725 hasConceptScore W4210630725C2778199505 @default.
- W4210630725 hasConceptScore W4210630725C2778609962 @default.
- W4210630725 hasConceptScore W4210630725C2779054382 @default.
- W4210630725 hasConceptScore W4210630725C2779306644 @default.
- W4210630725 hasConceptScore W4210630725C55493867 @default.
- W4210630725 hasConceptScore W4210630725C71240020 @default.
- W4210630725 hasConceptScore W4210630725C71924100 @default.
- W4210630725 hasConceptScore W4210630725C98274493 @default.
- W4210630725 hasIssue "5" @default.
- W4210630725 hasLocation W42106307251 @default.
- W4210630725 hasLocation W42106307252 @default.
- W4210630725 hasOpenAccess W4210630725 @default.
- W4210630725 hasPrimaryLocation W42106307251 @default.
- W4210630725 hasRelatedWork W2086618272 @default.
- W4210630725 hasRelatedWork W2088423161 @default.
- W4210630725 hasRelatedWork W2166056863 @default.
- W4210630725 hasRelatedWork W2281641305 @default.
- W4210630725 hasRelatedWork W2734027580 @default.
- W4210630725 hasRelatedWork W2782801137 @default.
- W4210630725 hasRelatedWork W2904062435 @default.
- W4210630725 hasRelatedWork W4210630725 @default.
- W4210630725 hasRelatedWork W1834508297 @default.
- W4210630725 hasRelatedWork W2164076695 @default.
- W4210630725 hasVolume "67" @default.
- W4210630725 isParatext "false" @default.
- W4210630725 isRetracted "false" @default.
- W4210630725 workType "article" @default.