FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210634788> ?p ?o ?g. }

• W4210634788 abstract "Introduction: Genetic studies of early-onset disease have been an effective strategy to identify novel pathways and drug targets generalizable also to later-onset disease. Few studies have investigated the sex-specific genetic associations with early-onset ischemic stroke even though several features of ischemic stroke differ between males and females. We hypothesized that stratifying the GWAS by sex would reveal novel stroke loci. Methods: We performed a transethnic ischemic stroke GWAS of 3,056 female cases and 4,462 male cases < 60 years-old and 16,192 and 16,048 sex-matched controls, respectively, from the Early Onset Stroke Genetics Consortium. Results: We identified a significant association in women with a locus in close proximity to TMX1 , a transmembrane platelet protein that inhibits platelet function. Additionally, we identified 2 other suggestive (P < 5 x 10 -6 ) loci in females (see Table), i.e., at APOH , which encodes beta2-glycoprotein I, an established GWAS locus for lipoprotein(a), and LRFN2 which has been previously reported to associate with obesity-related measures and type II diabetes. We observed suggestive evidence for association in males with MMP3/MMP12 , a known stroke susceptibility locus. Conclusions: Despite a very modest sample size, sex-specific analyses identified suggestive associations at biologically important novel loci in females and a known stroke locus in males. Further studies of sex-specific associations in both early- and later-onset ischemic stroke are needed." @default.
• W4210634788 created "2022-02-08" @default.
• W4210634788 creator A5001592746 @default.
• W4210634788 creator A5001693847 @default.
• W4210634788 creator A5002116555 @default.
• W4210634788 creator A5006664647 @default.
• W4210634788 creator A5010045617 @default.
• W4210634788 creator A5010581057 @default.
• W4210634788 creator A5010722813 @default.
• W4210634788 creator A5013802927 @default.
• W4210634788 creator A5018531683 @default.
• W4210634788 creator A5021332109 @default.
• W4210634788 creator A5021489611 @default.
• W4210634788 creator A5022072512 @default.
• W4210634788 creator A5022272750 @default.
• W4210634788 creator A5023456800 @default.
• W4210634788 creator A5026734876 @default.
• W4210634788 creator A5027044353 @default.
• W4210634788 creator A5027235235 @default.
• W4210634788 creator A5027947946 @default.
• W4210634788 creator A5033337810 @default.
• W4210634788 creator A5033502820 @default.
• W4210634788 creator A5033755499 @default.
• W4210634788 creator A5036197337 @default.
• W4210634788 creator A5040967520 @default.
• W4210634788 creator A5041219086 @default.
• W4210634788 creator A5044028607 @default.
• W4210634788 creator A5046467190 @default.
• W4210634788 creator A5051820798 @default.
• W4210634788 creator A5054423486 @default.
• W4210634788 creator A5056940847 @default.
• W4210634788 creator A5060878215 @default.
• W4210634788 creator A5061123357 @default.
• W4210634788 creator A5061275743 @default.
• W4210634788 creator A5061445522 @default.
• W4210634788 creator A5062319568 @default.
• W4210634788 creator A5062946236 @default.
• W4210634788 creator A5062964883 @default.
• W4210634788 creator A5063254454 @default.
• W4210634788 creator A5064334744 @default.
• W4210634788 creator A5066237154 @default.
• W4210634788 creator A5071151925 @default.
• W4210634788 creator A5075877585 @default.
• W4210634788 creator A5077333999 @default.
• W4210634788 creator A5077569991 @default.
• W4210634788 creator A5085407328 @default.
• W4210634788 creator A5086287565 @default.
• W4210634788 creator A5086723819 @default.
• W4210634788 creator A5086839394 @default.
• W4210634788 creator A5088230759 @default.
• W4210634788 creator A5089540833 @default.
• W4210634788 creator A9999999999 @default.
• W4210634788 date "2022-02-01" @default.
• W4210634788 modified "2023-10-18" @default.
• W4210634788 title "Abstract 154: Sex-specific Genome Wide Association Study Of Early-onset Ischemic Stroke" @default.
• W4210634788 doi "https://doi.org/10.1161/str.53.suppl_1.154" @default.
• W4210634788 hasPublicationYear "2022" @default.
• W4210634788 type Work @default.
• W4210634788 citedByCount "0" @default.
• W4210634788 crossrefType "journal-article" @default.
• W4210634788 hasAuthorship W4210634788A5001592746 @default.
• W4210634788 hasAuthorship W4210634788A5001693847 @default.
• W4210634788 hasAuthorship W4210634788A5002116555 @default.
• W4210634788 hasAuthorship W4210634788A5006664647 @default.
• W4210634788 hasAuthorship W4210634788A5010045617 @default.
• W4210634788 hasAuthorship W4210634788A5010581057 @default.
• W4210634788 hasAuthorship W4210634788A5010722813 @default.
• W4210634788 hasAuthorship W4210634788A5013802927 @default.
• W4210634788 hasAuthorship W4210634788A5018531683 @default.
• W4210634788 hasAuthorship W4210634788A5021332109 @default.
• W4210634788 hasAuthorship W4210634788A5021489611 @default.
• W4210634788 hasAuthorship W4210634788A5022072512 @default.
• W4210634788 hasAuthorship W4210634788A5022272750 @default.
• W4210634788 hasAuthorship W4210634788A5023456800 @default.
• W4210634788 hasAuthorship W4210634788A5026734876 @default.
• W4210634788 hasAuthorship W4210634788A5027044353 @default.
• W4210634788 hasAuthorship W4210634788A5027235235 @default.
• W4210634788 hasAuthorship W4210634788A5027947946 @default.
• W4210634788 hasAuthorship W4210634788A5033337810 @default.
• W4210634788 hasAuthorship W4210634788A5033502820 @default.
• W4210634788 hasAuthorship W4210634788A5033755499 @default.
• W4210634788 hasAuthorship W4210634788A5036197337 @default.
• W4210634788 hasAuthorship W4210634788A5040967520 @default.
• W4210634788 hasAuthorship W4210634788A5041219086 @default.
• W4210634788 hasAuthorship W4210634788A5044028607 @default.
• W4210634788 hasAuthorship W4210634788A5046467190 @default.
• W4210634788 hasAuthorship W4210634788A5051820798 @default.
• W4210634788 hasAuthorship W4210634788A5054423486 @default.
• W4210634788 hasAuthorship W4210634788A5056940847 @default.
• W4210634788 hasAuthorship W4210634788A5060878215 @default.
• W4210634788 hasAuthorship W4210634788A5061123357 @default.
• W4210634788 hasAuthorship W4210634788A5061275743 @default.
• W4210634788 hasAuthorship W4210634788A5061445522 @default.
• W4210634788 hasAuthorship W4210634788A5062319568 @default.
• W4210634788 hasAuthorship W4210634788A5062946236 @default.
• W4210634788 hasAuthorship W4210634788A5062964883 @default.
• W4210634788 hasAuthorship W4210634788A5063254454 @default.
• W4210634788 hasAuthorship W4210634788A5064334744 @default.
• W4210634788 hasAuthorship W4210634788A5066237154 @default.
• W4210634788 hasAuthorship W4210634788A5071151925 @default.

• next