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• W4210637514 startingPage "146236" @default.
• W4210637514 abstract "Xenopus laevis, the African clawed frog, undergoes seasonal estivation to survive periods of drought when its lake-bed habitats dry up. The frog can lose ∼30% of its total body water, leading to conditions of impaired blood flow and ischemia which risk cellular survival under these harsh conditions. MicroRNAs are short, noncoding, single-stranded RNAs 21-24 nt long that have been widely implicated in hypometabolic responses, and serve functions including apoptosis survival. The levels of three pro-apoptotic and four anti-apoptotic miRNAs were measured in liver and skeletal muscle of estivating X. laevis, and bioinformatic analysis was performed to verify potential mRNA targets of these miRNAs. Members of pro-apoptotic miRNAs miR-15a, miR-16, and miR-101 showed upregulation as a result of dehydration stress, while anti-apoptotic miRNAs miR-19b, miR-21, miR-92a, and miR-155 showed differential regulation between the two tissues. Together, these miRNAs act in a more diverse fashion than arbitrarily pro- or anti-apoptotic, and encompass functions ranging from the inhibition of cell proliferation through cell cycle arrest to the prevention of skeletal muscle atrophy." @default.
• W4210637514 created "2022-02-08" @default.
• W4210637514 creator A5017537180 @default.
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• W4210637514 date "2022-04-01" @default.
• W4210637514 modified "2023-09-30" @default.
• W4210637514 title "Pro- and anti-apoptotic microRNAs are differentially regulated during estivation in Xenopus laevis" @default.
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• W4210637514 doi "https://doi.org/10.1016/j.gene.2022.146236" @default.
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