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- W4210637580 abstract "Numerous studies have evaluated the presence of anemia in patients with hidradenitis suppurativa (HS), and conflicting findings have characterized this anemia as either anemia of chronic disease (ACD) or iron deficiency anemia (IDA). Patients with HS have immune dysregulation and elevated inflammatory mediators, including interleukin (IL)-6, which have been linked with ACD in other inflammatory conditions. Interleukin-6 induces ferritin transcription and translation, resulting in increased iron storage, as well as stimulation of hepcidin production, resulting in decreased iron absorption and release in the circulation. We studied the utility of serum IL-6 as a marker of ACD in patients with HS, inquiring if we could differentiate ACD from IDA to guide therapy for anemia in HS patients. In this cross-sectional study, serum samples from 63 anemic patients seen at a specialized HS Center were analyzed. Based on iron parameters, patients were divided into cohorts suggestive of either ACD or IDA. Anemic patients with adequate iron stores (n = 39, ferritin >30 ng/mL) were assigned to the ACD cohort. These patients had greater disease severity (Hurley stage and HS-Physician Global Assessment scores), serum IL-6 (13.4 vs 2.75 ng/mL, P = .003), and serum hepcidin (23.3 vs 3.24 ng/mL, P < .0001) compared with patients with reduced iron stores. These findings suggest that patients with HS may suffer from either ACD or IDA, and both disease severity and IL-6 are useful for classifying the types of anemia. Furthermore, this study affirms the utility of IL-6 as a predictor of both disease severity and ACD in patients with HS." @default.
- W4210637580 created "2022-02-08" @default.
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- W4210637580 date "2021-09-01" @default.
- W4210637580 modified "2023-09-27" @default.
- W4210637580 title "25375 The role of interleukin-6 in anemia associated with hidradenitis suppurativa" @default.
- W4210637580 doi "https://doi.org/10.1016/j.jaad.2021.06.049" @default.
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