Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210637938> ?p ?o ?g. }
- W4210637938 abstract "The microtubule-associated protein tau plays an important role in tauopathic diseases such as Alzheimer's disease and primary tauopathies such as progressive supranuclear palsy and corticobasal degeneration. Tauopathy animal models, such as transgenic, knock-in mouse and rat models, recapitulating tauopathy have facilitated the understanding of disease mechanisms. Aberrant accumulation of hyperphosphorylated tau contributes to synaptic deficits, neuroinflammation, and neurodegeneration, leading to cognitive impairment in animal models. Recent advances in molecular imaging using positron emission tomography (PET) and magnetic resonance imaging (MRI) have provided valuable insights into the time course of disease pathophysiology in tauopathy animal models. High-field MRI has been applied for in vivo imaging in animal models of tauopathy, including diffusion tensor imaging for white matter integrity, arterial spin labeling for cerebral blood flow, resting-state functional MRI for functional connectivity, volumetric MRI for neurodegeneration, and MR spectroscopy. In addition, MR contrast agents for non-invasive imaging of tau have been developed recently. Many preclinical MRI indicators offer excellent translational value and provide a blueprint for clinical MRI in the brains of patients with tauopathies. In this review, we summarized the recent advances in using MRI to visualize the pathophysiology of tauopathy in small animals. We discussed the outstanding challenges in brain imaging using MRI in small animals and propose a future outlook for visualizing tau-related alterations in the brains of animal models." @default.
- W4210637938 created "2022-02-08" @default.
- W4210637938 creator A5051431217 @default.
- W4210637938 date "2022-01-25" @default.
- W4210637938 modified "2023-09-26" @default.
- W4210637938 title "Magnetic Resonance Imaging in Tauopathy Animal Models" @default.
- W4210637938 cites W1480786153 @default.
- W4210637938 cites W1836507030 @default.
- W4210637938 cites W1940013884 @default.
- W4210637938 cites W1968276382 @default.
- W4210637938 cites W1968553823 @default.
- W4210637938 cites W1969125278 @default.
- W4210637938 cites W1970936375 @default.
- W4210637938 cites W1972796316 @default.
- W4210637938 cites W1972933275 @default.
- W4210637938 cites W1973685603 @default.
- W4210637938 cites W1986986092 @default.
- W4210637938 cites W1994282166 @default.
- W4210637938 cites W1997222702 @default.
- W4210637938 cites W2009870816 @default.
- W4210637938 cites W2034286717 @default.
- W4210637938 cites W2046614450 @default.
- W4210637938 cites W2048685634 @default.
- W4210637938 cites W2053535174 @default.
- W4210637938 cites W2057249855 @default.
- W4210637938 cites W2058829280 @default.
- W4210637938 cites W2062131497 @default.
- W4210637938 cites W2064899413 @default.
- W4210637938 cites W2066343382 @default.
- W4210637938 cites W2080050622 @default.
- W4210637938 cites W2082429191 @default.
- W4210637938 cites W2084009613 @default.
- W4210637938 cites W2084691579 @default.
- W4210637938 cites W2090523774 @default.
- W4210637938 cites W2092889411 @default.
- W4210637938 cites W2095963715 @default.
- W4210637938 cites W2099292814 @default.
- W4210637938 cites W2099340107 @default.
- W4210637938 cites W2101334128 @default.
- W4210637938 cites W2107804537 @default.
- W4210637938 cites W2120259577 @default.
- W4210637938 cites W2129006179 @default.
- W4210637938 cites W2130723719 @default.
- W4210637938 cites W2135309154 @default.
- W4210637938 cites W2155593760 @default.
- W4210637938 cites W2156295356 @default.
- W4210637938 cites W2157899039 @default.
- W4210637938 cites W2160544094 @default.
- W4210637938 cites W2160917765 @default.
- W4210637938 cites W2171682109 @default.
- W4210637938 cites W2206024306 @default.
- W4210637938 cites W2206932523 @default.
- W4210637938 cites W2342878717 @default.
- W4210637938 cites W2410011917 @default.
- W4210637938 cites W2432921005 @default.
- W4210637938 cites W2472346278 @default.
- W4210637938 cites W2563917135 @default.
- W4210637938 cites W2579510648 @default.
- W4210637938 cites W2582711285 @default.
- W4210637938 cites W2583611319 @default.
- W4210637938 cites W2583982124 @default.
- W4210637938 cites W2599826853 @default.
- W4210637938 cites W2603922658 @default.
- W4210637938 cites W2606970762 @default.
- W4210637938 cites W2611281735 @default.
- W4210637938 cites W2616673695 @default.
- W4210637938 cites W2625115119 @default.
- W4210637938 cites W2743172238 @default.
- W4210637938 cites W2744561951 @default.
- W4210637938 cites W2754064880 @default.
- W4210637938 cites W2765664776 @default.
- W4210637938 cites W2766040060 @default.
- W4210637938 cites W2779463443 @default.
- W4210637938 cites W2783539126 @default.
- W4210637938 cites W2785763878 @default.
- W4210637938 cites W2793474747 @default.
- W4210637938 cites W2794050431 @default.
- W4210637938 cites W2800592461 @default.
- W4210637938 cites W2806037964 @default.
- W4210637938 cites W2806074443 @default.
- W4210637938 cites W2808028315 @default.
- W4210637938 cites W2886075445 @default.
- W4210637938 cites W2886280457 @default.
- W4210637938 cites W2888184930 @default.
- W4210637938 cites W2888559669 @default.
- W4210637938 cites W2889808182 @default.
- W4210637938 cites W2896682297 @default.
- W4210637938 cites W2903117173 @default.
- W4210637938 cites W2903492984 @default.
- W4210637938 cites W2903697160 @default.
- W4210637938 cites W2904608802 @default.
- W4210637938 cites W2908873665 @default.
- W4210637938 cites W2910371692 @default.
- W4210637938 cites W2912954741 @default.
- W4210637938 cites W2913528204 @default.
- W4210637938 cites W2914916753 @default.
- W4210637938 cites W2922355439 @default.
- W4210637938 cites W2922829546 @default.
- W4210637938 cites W2924415036 @default.
- W4210637938 cites W2926570714 @default.